Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin

Friend, Mitchell Thomas; Parker, Tracey Gannon; Mastren, Tara; Mocko, Veronika; Brugh, Mark; Birnbaum, Eva R.; Fassbender, Michael Ernst

doi:10.1016/j.chroma.2020.461219

Title: Extraction chromatography of ²²⁵Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin

Journal Article · Sat May 23 00:00:00 EDT 2020 · Journal of Chromatography

DOI:https://doi.org/10.1016/j.chroma.2020.461219· OSTI ID:1631575

^[1]; Parker, Tracey Gannon ^[1];

^[2];

^[1]; Brugh, Mark ^[1];

^[1];

^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of Utah, Salt Lake City, UT (United States)

The alpha-emitter ²²⁵Ac (t_1/2 = 9.92 d) is currently under development for targeted alpha-particle therapy of cancer, and accelerator production of ²²⁵Ac via proton irradiation of thorium targets requires robust separations of ²²⁵Ac from chemically similar fission product lanthanides. Additionally, the lanthanide elements represent critical components in modern technologies, and radiolanthanides such as ¹⁴⁰Nd (t_1/2 = 3.37 d) also have potential application in the field of nuclear medicine. The ionic liquid, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([Bmim][NTf₂]), combined with the diglycolamide extractant, N,N-dioctyldiglycolamic acid (DODGAA), was adsorbed on macroporous resin support to produce a solvent impregnated resin (SIR) that was investigated for separations of ²²⁵Ac and lanthanides. The equilibrium distribution coefficients (Kd) of the rare earth elements (Sc(III), Y(III), Ln(III)), ²²⁵Ac(III), Th(IV), and U(VI) on the prepared DODGAA/[Bmim][NTf₂]-SIR were determined from batch adsorption experiments in HCl and HNO₃ media. The DODGAA/[Bmim][NTf2]-SIR exhibited preferential uptake of the heavier lanthanide elements while allowing for the separation of the lighter lanthanides. Column separations utilizing the DODGAA/[Bmim][NTf₂]-SIR were effective at separating the lighter lanthanides from each other, and separating ²²⁵Ac from a mixture of lanthanides, ²¹³Bi, and ²²⁵Ra without the need for additional complexing agents.

View Accepted Manuscript (DOE)

View Accepted Manuscript (Publisher)

Cite

Export

Save

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Office of Science (SC). Nuclear Physics (NP) (SC-26); USDOE

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 1631575

Alternate ID(s):: OSTI ID: 1775849

Report Number(s):: LA-UR-20-21569

Journal Information:: Journal of Chromatography, Vol. 1624, Issue C; ISSN 0021-9673

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 12 works

Citation information provided by
Web of Science

References (34)

An Overview of Targeted Alpha Therapy with ²²⁵ Actinium and ²¹³ Bismuth Morgenstern, Alfred; Apostolidis, Christos; Kratochwil, Clemens Current Radiopharmaceuticals, Vol. 11, Issue 3 https://doi.org/10.2174/1874471011666180502104524	journal	October 2018
Production of Ac-225 from Th-229 for Targeted α Therapy Apostolidis, C.; Molinet, R.; Rasmussen, G. Analytical Chemistry, Vol. 77, Issue 19 https://doi.org/10.1021/ac0580114	journal	October 2005
Therapeutic Radionuclides: Biophysical and Radiobiologic Principles Kassis, Amin I. Seminars in Nuclear Medicine, Vol. 38, Issue 5 https://doi.org/10.1053/j.semnuclmed.2008.05.002	journal	September 2008
Alpha-Emitters and Targeted Alpha Therapy in Oncology: from Basic Science to Clinical Investigations Makvandi, Mehran; Dupis, Edouard; Engle, Jonathan W. Targeted Oncology, Vol. 13, Issue 2 https://doi.org/10.1007/s11523-018-0550-9	journal	February 2018
Present and Future Prospects of Radiation Therapy Using α-Emitting Nuclides Kojima, Shuji; Cuttler, Jerry M.; Shimura, Noriko Dose-Response, Vol. 16, Issue 1 https://doi.org/10.1177/1559325817747387	journal	January 2018
225Ac-PSMA-617 for PSMA-Targeted -Radiation Therapy of Metastatic Castration-Resistant Prostate Cancer Kratochwil, C.; Bruchertseifer, F.; Giesel, F. L. Journal of Nuclear Medicine, Vol. 57, Issue 12 https://doi.org/10.2967/jnumed.116.178673	journal	July 2016
Production of actinium-225 for alpha particle mediated radioimmunotherapy Boll, Rose A.; Malkemus, Dairin; Mirzadeh, Saed Applied Radiation and Isotopes, Vol. 62, Issue 5 https://doi.org/10.1016/j.apradiso.2004.12.003	journal	May 2005
Ac, La, and Ce radioimpurities in 225Ac produced in 40–200 MeV proton irradiations of thorium Engle, Jonathan W.; Weidner, John W.; Ballard, Beau D. Radiochimica Acta, Vol. 102, Issue 7 https://doi.org/10.1515/ract-2013-2179	journal	January 2014
Proton-induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200MeV Weidner, J. W.; Mashnik, S. G.; John, K. D. Applied Radiation and Isotopes, Vol. 70, Issue 11 https://doi.org/10.1016/j.apradiso.2012.07.006	journal	November 2012
Large scale accelerator production of 225Ac: Effective cross sections for 78–192 MeV protons incident on 232Th targets Griswold, J. R.; Medvedev, D. G.; Engle, J. W. Applied Radiation and Isotopes, Vol. 118 https://doi.org/10.1016/j.apradiso.2016.09.026	journal	December 2016
Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes Radchenko, V.; Engle, J. W.; Wilson, J. J. Journal of Chromatography A, Vol. 1380, p. 55-63 https://doi.org/10.1016/j.chroma.2014.12.045	journal	February 2015
Selective separation of radium and actinium from bulk thorium target material on strong acid cation exchange resin from sulfate media McAlister, Daniel R.; Horwitz, E. Philip Applied Radiation and Isotopes, Vol. 140 https://doi.org/10.1016/j.apradiso.2018.06.008	journal	October 2018
An Improved Method for the Production of Ac‐225/Bi‐213 from Th‐229 for Targeted Alpha Therapy Zielinska, B.; Apostolidis, C.; Bruchertseifer, F. Solvent Extraction and Ion Exchange, Vol. 25, Issue 3 https://doi.org/10.1080/07366290701285108	journal	April 2007
Radiometric evaluation of diglycolamide resins for the chromatographic separation of actinium from fission product lanthanides Radchenko, Valery; Mastren, Tara; Meyer, Catherine A. L. Talanta, Vol. 175 https://doi.org/10.1016/j.talanta.2017.07.057	journal	December 2017
Benefiting from the Unique Properties of Lanthanide Ions Bünzli, Jean-Claude G. Accounts of Chemical Research, Vol. 39, Issue 1 https://doi.org/10.1021/ar0400894	journal	January 2006
Lanthanide-Based Luminescent Hybrid Materials Binnemans, Koen Chemical Reviews, Vol. 109, Issue 9 https://doi.org/10.1021/cr8003983	journal	September 2009
Nuclear forensic analysis of an unknown uranium ore concentrate sample seized in a criminal investigation in Australia Keegan, Elizabeth; Kristo, Michael J.; Colella, Michael Forensic Science International, Vol. 240 https://doi.org/10.1016/j.forsciint.2014.04.004	journal	July 2014
Application of radioisotopes in the field of nuclear medicine: I. Lanthanide series elements Nayak, D.; Lahiri, S. Journal of Radioanalytical and Nuclear Chemistry, Vol. 242, Issue 2 https://doi.org/10.1007/BF02345573	journal	November 1999
Experimental measurements and nuclear model calculations on the excitation functions of natCe(3He, xn) and 141Pr(p, xn) reactions with special reference to production of the therapeutic radionuclide 140Nd Hilgers, K.; Shubin, Yu. N.; Coenen, Heinz H. Radiochimica Acta, Vol. 93, Issue 9-10 https://doi.org/10.1524/ract.2005.93.9-10.553	journal	January 2005
Extraction of Rare Earths in Ionic Liquids Via Competitive Ligand Complexation between TODGA and DTPA Dehaudt, Jérémy; Williams, Neil J.; Luo, Huimin Solvent Extraction and Ion Exchange, Vol. 36, Issue 6 https://doi.org/10.1080/07366299.2018.1545343	journal	September 2018
Application of a functionalized ionic liquid extractant tributylmethylammonium dibutyldiglycolamate ([A336][BDGA]) in light rare earth extraction and separation Qiu, Lina; Pan, Yuhong; Zhang, Weiwei PLOS ONE, Vol. 13, Issue 8 https://doi.org/10.1371/journal.pone.0201405	journal	August 2018
Application of ionic liquids in the preparation of extraction chromatographic materials for metal ion separations: Progress and prospects Hawkins, C. A.; Momen, Md. A.; Dietz, M. L. Separation Science and Technology, Vol. 53, Issue 12 https://doi.org/10.1080/01496395.2017.1302478	journal	May 2017
Solvent-impregnated resins (SIRs) – Methods of preparation and their applications Kabay, Nalan; Cortina, Jose Luis; Trochimczuk, Andrzej Reactive and Functional Polymers, Vol. 70, Issue 8 https://doi.org/10.1016/j.reactfunctpolym.2010.01.005	journal	August 2010
The solid–liquid extraction of yttrium from rare earths by solvent (ionic liquid) impreganated resin coupled with complexing method Sun, Xiaoqi; Peng, Bo; Ji, Yang Separation and Purification Technology, Vol. 63, Issue 1 https://doi.org/10.1016/j.seppur.2008.03.038	journal	October 2008
Use of extraction chromatography in the recycling of critical metals from thin film leach solutions Schaeffer, Nicolas; Grimes, Sue M.; Cheeseman, Chris R. Inorganica Chimica Acta, Vol. 457 https://doi.org/10.1016/j.ica.2016.11.020	journal	March 2017
Solvent extraction-separation of La(III), Eu(III) and Er(III) ions from aqueous chloride medium using carbamoyl-carboxylic acid extractants Safarbali, Reyhaneh; Yaftian, Mohammad Reza; Zamani, Abbasali Journal of Rare Earths, Vol. 34, Issue 1 https://doi.org/10.1016/S1002-0721(14)60583-4	journal	January 2016
Synthesis and Characterization of the Actinium Aquo Ion Ferrier, Maryline G.; Stein, Benjamin W.; Batista, Enrique R. ACS Central Science, Vol. 3, Issue 3 https://doi.org/10.1021/acscentsci.6b00356	journal	February 2017
Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides Shannon, R. D. Acta Crystallographica Section A, Vol. 32, Issue 5, p. 751-767 https://doi.org/10.1107/S0567739476001551	journal	September 1976
Production and Radiochemical Separation of the Auger Electron Emitter ¹⁴⁰ Nd Rösch, Jörg Brockmann, Nikolai A. L., Frank Acta Oncologica, Vol. 39, Issue 6 https://doi.org/10.1080/028418600750063794	journal	January 2000
A 140Nd/140Pr radionuclide generator based on physico-chemical transitions in 140Pr complexes after electron capture decay of 140Nd-DOTA Zhernosekov, K. P.; Filosofov, D. V.; Qaim, Syed M. Radiochimica Acta, Vol. 95, Issue 6 https://doi.org/10.1524/ract.2007.95.6.319	journal	January 2007
Glacial-interglacial circulation changes inferred from ²³¹ Pa/ ²³⁰ Th sedimentary record in the North Atlantic region : MOC CHANGES INFERRED FROM Pa/Th RECORDS Gherardi, J. -M.; Labeyrie, L.; Nave, S. Paleoceanography, Vol. 24, Issue 2 https://doi.org/10.1029/2008PA001696	journal	May 2009
Determination of the age of highly enriched uranium M., Wallenius; A., Morgenstern; C., Apostolidis Analytical and Bioanalytical Chemistry, Vol. 374, Issue 3 https://doi.org/10.1007/s00216-002-1555-9	journal	October 2002
A method for dating small amounts of uranium Pointurier, Fabien; Hubert, Amélie; Roger, Gaëlle Journal of Radioanalytical and Nuclear Chemistry, Vol. 296, Issue 2 https://doi.org/10.1007/s10967-012-2198-8	journal	September 2012
Distribution coefficients of 60 elements on TODGA resin: Application to Ca, Lu, Hf, U and Th isotope geochemistry Pourmand, Ali; Dauphas, Nicolas Talanta, Vol. 81, Issue 3 https://doi.org/10.1016/j.talanta.2010.01.008	journal	May 2010

Similar Records

Molecular dynamics simulations of n-hexane at 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl) imide interface

Journal Article · Sun Jul 07 00:00:00 EDT 2013 · Journal of Chemical Physics · OSTI ID:1631575

Lisal, Martin; Izak, Pavel

How mixing tetraglyme with the ionic liquid 1-n-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide changes volumetric and transport properties: An experimental and computational study

Journal Article · Wed Feb 01 00:00:00 EST 2017 · Chemical Engineering Science · OSTI ID:1631575

Sharma, Akash; Zhang, Yong; Gohndrone, Thomas; +4 more

Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes

Journal Article · Thu Dec 18 00:00:00 EST 2014 · Journal of Chromatography · OSTI ID:1631575

Radchenko, Valery; Engle, Jonathan W.; Wilson, Justin Jeff; +7 more

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Title: Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin

Citation Formats

References (34)

Similar Records

Related Subjects

Title: Extraction chromatography of ²²⁵Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin