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Title: GDP-L-fucose transport in plants: The missing piece

Journal Article · · Channels (Austin, Tex.)
 [1];  [1];  [1]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Joint BioEnergy Institute and Environmental Genomics and Systems Biology Division; Univ. of Melbourne (Australia). School of BioSciences
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The monosaccharide fucose is an important deoxyhexose occurring in plants, fungi and animals. Fucose is mainly found as a component of glycan structures such as N- and O-linked glycans, glycolipids and in cell wall polysaccharides such as fucoidan, xyloglucan, rhamnogalacturonan II. The biosynthesis of these glycan structures is mediated by glycosyltransferases and typically occurs within the endomembrane system. Fucosylation reactions require an activated sugar in the form of GDP-L-fucose (GDP-Fuc) which is either biosynthesized de novo or can also be salvaged from fucose in the cytosol. This partitioning necessitates active GDP-Fuc transport into the endomembrane system for glycosylation reactions. To date, GDP-Fuc transporters have been characterized in mammals (Homo sapiens), insects (Drosophila melanogaster) and nematodes (Caenorhabditis elegans), reviewed in. However, given the importance of fucose containing structures in plants, the absence of a characterized GDP-Fuc transporter has, until recently, been a dilemma. Thus, the recent identification of a GDP-Fuc transporter (GFT1) in the reference plant Arabidopsis thaliana represents the final missing piece of GDP-Fuc metabolism in plants.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
Grant/Contract Number:
AC02-05CH11231
OSTI ID:
1629584
Journal Information:
Channels (Austin, Tex.), Vol. 11, Issue 1; ISSN 1933-6950
Publisher:
Taylor & FrancisCopyright Statement
Country of Publication:
United States
Language:
English

References (8)

The Arabidopsis Golgi-localized GDP-L-fucose transporter is required for plant development journal July 2016
Overview of Nucleotide Sugar Transporter Gene Family Functions Across Multiple Species journal August 2016
The Golgi localized bifunctional UDP-rhamnose/UDP-galactose transporter family of Arabidopsis journal July 2014
Slc35c2 Promotes Notch1 Fucosylation and Is Required for Optimal Notch Signaling in Mammalian Cells journal September 2010
Identification and Characterization of GONST1, a Golgi-Localized GDP-Mannose Transporter in Arabidopsis journal October 2001
VvGONST-A and VvGONST-B are Golgi-localised GDP-sugar transporters in grapevine (Vitis vinifera L.) journal February 2015
Characterization of an fungal l-fucokinase involved in Mortierella alpina GDP-l-fucose salvage pathway journal March 2016
The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter journal May 2001

Cited By (1)

Characterization of a GDP-Fucose Transporter and a Fucosyltransferase Involved in the Fucosylation of Glycoproteins in the Diatom Phaeodactylum tricornutum journal May 2019

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59 BASIC BIOLOGICAL SCIENCES
Golgi apparatus
nucleotide sugars