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Title: Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings

Journal Article · · Nature Communications
DOI:https://doi.org/10.1038/ncomms3659· OSTI ID:1623929
 [1];  [1];  [1];  [1];  [1];  [1];  [1];  [2];  [2];  [3]
  1. National Institutes of Health (NIH), Bethesda, MD (United States)
  2. Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
  3. Pennsylvania State Univ., University Park, PA (United States)
+ Show Author Affiliations

Hard X-ray phase-contrast imaging characterizes the electron density distribution in an object without the need for radiation absorption. The power of phase contrast to resolve subtle changes, such as those in soft tissue structures, lies in its ability to detect minute refractive bending of X-rays. Here we report a far-field, two-arm interferometer based on the new nanometric phase gratings, which can detect X-ray refraction with subnanoradian sensitivity, and at the same time overcomes the fundamental limitation of ultra-narrow bandwidths (Dl/lB10 4) of the current, most sensitive methods based on crystal interferometers. On a 1.5% bandwidth synchrotron source, we demonstrate clear visualization of blood vessels in unstained mouse organs in simple projection views, with over an order-of-magnitude higher phase contrast than current near-field grating interferometers.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
1623929
Journal Information:
Nature Communications, Vol. 4, Issue 1; ISSN 2041-1723
Publisher:
Nature Publishing GroupCopyright Statement
Country of Publication:
United States
Language:
English

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Cited By (8)

Fast X-ray Differential Phase Contrast Imaging with One Exposure and without Movements journal February 2019
Talbot-Lau x-ray phase-contrast setup for fast scanning of large samples journal March 2019
A quantitative correction for phase wrapping artifacts in hard X-ray grating interferometry journal August 2018
Efficient Decoding of 2D Structured Illumination with Linear Phase Stepping in X-Ray Phase Contrast and Dark-Field Imaging journal January 2014
Talbot-Lau x-ray phase-contrast setup for fast scanning of large samples text January 2019
Fabrication of 200 nm Period Hard X-ray Phase Gratings journal May 2014
Trabecular bone anisotropy imaging with a compact laser-undulator synchrotron x-ray source journal November 2017
Quasi suppression of higher-order diffractions with inclined rectangular apertures gratings journal November 2015

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