NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance

Pak, Joseph S.; DeLoughery, Zachary J.; Wang, Jing; Acharya, Nischal; Park, Yeonwoo; Jaworski, Alexander; Özkan, Engin

doi:10.1038/s41467-020-15211-1

Title: NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance

Journal Article · Fri Mar 20 00:00:00 EDT 2020 · Nature Communications

DOI:https://doi.org/10.1038/s41467-020-15211-1· OSTI ID:1608059

^[1];

^[2]; Wang, Jing ^[1]; Acharya, Nischal ^[2]; Park, Yeonwoo ^[3];

^[2];

^[1]

Univ. of Chicago, IL (United States). Grossman Inst. for Neuroscience, Quantitative Biology and Human Behavior
Brown Univ., Providence, RI (United States); Robert J. and Nancy D. Carney Inst. for Brain Science, Providence, RI (United States)
Univ. of Chicago, IL (United States)

Axon pathfinding is critical for nervous system development, and it is orchestrated by molecular cues that activate receptors on the axonal growth cone. Robo family receptors bind Slit guidance cues to mediate axon repulsion. In mammals, the divergent family member Robo3 does not bind Slits, but instead signals axon repulsion from its own ligand, NELL2. Conversely, canonical Robos do not mediate NELL2 signaling. Here, we present the structures of NELL-Robo3 complexes, identifying a mode of ligand engagement for Robos that is orthogonal to Slit binding. We elucidate the structural basis for differential binding between NELL and Robo family members and show that NELL2 repulsive activity is a function of its Robo3 affinity and is enhanced by ligand trimerization. Our results reveal a mechanism of oligomerization-induced Robo activation for axon guidance and shed light on Robo family member ligand binding specificity, conformational variability, divergent modes of signaling, and evolution.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: National Institutes of Health (NIH); National Institute of General Medical Sciences (NIGMS); USDOE Office of Science (SC)

Grant/Contract Number:: AC02-06CH11357; T32 GM077995; R01 NS097161; R01 MH114102; RI-INBRE P20 GM103430; R01 NS095908; S10 RR029205; 1S10OD012289-01A1; 9 P41 GM103622; 1S10OD018090-01

OSTI ID:: 1608059

Journal Information:: Nature Communications, Vol. 11, Issue 1; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

Citation Metrics:

Cited by: 21 works

Citation information provided by
Web of Science

References (68)

Uniqueness of ab initio shape determination in small-angle scattering Volkov, Vladimir V.; Svergun, Dmitri I. Journal of Applied Crystallography, Vol. 36, Issue 3, p. 860-864 https://doi.org/10.1107/S0021889803000268	journal	April 2003
Structural Divergence in O-GlcNAc Glycans Displayed on Epidermal Growth Factor-like Repeats of Mammalian Notch1 Ogawa, Mitsutaka; Senoo, Yuya; Ikeda, Kazutaka Molecules, Vol. 23, Issue 7 https://doi.org/10.3390/molecules23071745	journal	July 2018
DAMMIF, a program for rapid ab-initio shape determination in small-angle scattering Franke, Daniel; Svergun, Dmitri I. Journal of Applied Crystallography, Vol. 42, Issue 2, p. 342-346 https://doi.org/10.1107/S0021889809000338	journal	January 2009
Slit-Robo signaling Blockus, Heike; Chédotal, Alain Development, Vol. 143, Issue 17 https://doi.org/10.1242/dev.132829	journal	August 2016
Regulation of Commissural Axon Pathfinding by Slit and its Robo Receptors Dickson, Barry J.; Gilestro, Giorgio F. Annual Review of Cell and Developmental Biology, Vol. 22, Issue 1 https://doi.org/10.1146/annurev.cellbio.21.090704.151234	journal	November 2006
BioXTAS RAW : improvements to a free open-source program for small-angle X-ray scattering data reduction and analysis Hopkins, Jesse Bennett; Gillilan, Richard E.; Skou, Soren Journal of Applied Crystallography, Vol. 50, Issue 5 https://doi.org/10.1107/S1600576717011438	journal	September 2017
Structural insights into the Slit-Robo complex Morlot, C.; Thielens, N. M.; Ravelli, R. B. G. Proceedings of the National Academy of Sciences, Vol. 104, Issue 38 https://doi.org/10.1073/pnas.0705310104	journal	September 2007
TheDUTT1Gene, a Novel NCAM Family Member Is Expressed in Developing Murine Neural Tissues and Has an Unusually Broad Pattern of Expression Sundaresan, Vasi; Roberts, Ian; Bateman, Alex Molecular and Cellular Neuroscience, Vol. 11, Issue 1-2 https://doi.org/10.1006/mcne.1998.0672	journal	May 1998
New gene, nel, encoding a Mr 93 K protein with EGF-like repeats is strongly expressed in neural tissues of early stage chick embryos Matshuhashi, Sachiko; Noji, Sumihare; Koyama, Eiki Developmental Dynamics, Vol. 203, Issue 2 https://doi.org/10.1002/aja.1002030209	journal	June 1995
Nell2 regulates the contralateral-versus-ipsilateral visual projection as a domain-specific positional cue Nakamoto, Chizu; Durward, Elaine; Horie, Masato Development, Vol. 146, Issue 4 https://doi.org/10.1242/dev.170704	journal	February 2019
Signaling Switch of the Axon Guidance Receptor Robo3 during Vertebrate Evolution Zelina, Pavol; Blockus, Heike; Zagar, Yvrick Neuron, Vol. 84, Issue 6 https://doi.org/10.1016/j.neuron.2014.11.004	journal	December 2014
Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord Kennedy, Timothy E.; Serafini, Tito; de la Torre, JoséR. Cell, Vol. 78, Issue 3 https://doi.org/10.1016/0092-8674(94)90421-9	journal	August 1994
Sonic Hedgehog Guides Axons through a Noncanonical, Src-Family-Kinase-Dependent Signaling Pathway Yam, Patricia T.; Langlois, Sébastien D.; Morin, Steves Neuron, Vol. 62, Issue 3 https://doi.org/10.1016/j.neuron.2009.03.022	journal	May 2009
Towards automated crystallographic structure refinement with phenix.refine Afonine, Pavel V.; Grosse-Kunstleve, Ralf W.; Echols, Nathaniel Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 4 https://doi.org/10.1107/S0907444912001308	journal	March 2012
Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding Liu, Zhe; Patel, Kalpana; Schmidt, Hannes Molecular and Cellular Neuroscience, Vol. 26, Issue 2 https://doi.org/10.1016/j.mcn.2004.01.002	journal	June 2004
Overview of Current Methods in Sedimentation Velocity and Sedimentation Equilibrium Analytical Ultracentrifugation Zhao, Huaying; Brautigam, Chad A.; Ghirlando, Rodolfo Current Protocols in Protein Science, Vol. 71, Issue 1 https://doi.org/10.1002/0471140864.ps2012s71	journal	February 2013
Robo Ig4 Is a Dimerization Domain Yom-Tov, Galit; Barak, Reut; Matalon, Omri Journal of Molecular Biology, Vol. 429, Issue 23 https://doi.org/10.1016/j.jmb.2017.10.002	journal	November 2017
Alternative Splicing of the Robo3 Axon Guidance Receptor Governs the Midline Switch from Attraction to Repulsion Chen, Zhe; Gore, Bryan B.; Long, Hua Neuron, Vol. 58, Issue 3 https://doi.org/10.1016/j.neuron.2008.02.016	journal	May 2008
Magic Roundabout Is a New Member of the Roundabout Receptor Family That Is Endothelial Specific and Expressed at Sites of Active Angiogenesis Huminiecki, Lukasz; Gorn, Michael; Suchting, Steven Genomics, Vol. 79, Issue 4 https://doi.org/10.1006/geno.2002.6745	journal	April 2002
Robo family of proteins exhibit differential expression in mouse spinal cord and Robo-Slit interaction is required for midline crossing in vertebrate spinal cord Mambetisaeva, Elvira T.; Andrews, William; Camurri, Laura Developmental Dynamics, Vol. 233, Issue 1 https://doi.org/10.1002/dvdy.20324	journal	January 2005
Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard Terwilliger, Thomas C.; Adams, Paul D.; Read, Randy J. Acta Crystallographica Section D Biological Crystallography, Vol. 65, Issue 6 https://doi.org/10.1107/S0907444909012098	journal	May 2009
Structure and functional relevance of the Slit2 homodimerization domain Seiradake, Elena; von Philipsborn, Anne C.; Henry, Maud EMBO reports, Vol. 10, Issue 7 https://doi.org/10.1038/embor.2009.95	journal	May 2009
Production of selenomethionyl-derivatized proteins in baculovirus-infected insect cells Cronin, Ciarán N.; Lim, Kheng B.; Rogers, Joe Protein Science, Vol. 16, Issue 9 https://doi.org/10.1110/ps.072931407	journal	September 2007
Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2 Kuroda, Shun'ichi; Oyasu, Miho; Kawakami, Masakatsu Biochemical and Biophysical Research Communications, Vol. 265, Issue 1, p. 79-86 https://doi.org/10.1006/bbrc.1999.1638	journal	November 1999
Restricted neural epidermal growth factor-like like 2 (NELL2) expression during muscle and neuronal differentiation Nelson, Branden R.; Matsuhashi, Sachiko; Lefcort, Frances Mechanisms of Development, Vol. 119 https://doi.org/10.1016/S0925-4773(03)00084-4	journal	December 2002
Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism Xu, K.; Wu, Z.; Renier, N. Science, Vol. 344, Issue 6189 https://doi.org/10.1126/science.1255149	journal	May 2014
Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling Schuck, Peter Biophysical Journal, Vol. 78, Issue 3 https://doi.org/10.1016/S0006-3495(00)76713-0	journal	March 2000
Revisiting Netrin-1: One Who Guides (Axons) Boyer, Nicholas P.; Gupton, Stephanie L. Frontiers in Cellular Neuroscience, Vol. 12 https://doi.org/10.3389/fncel.2018.00221	journal	July 2018
Structural Principles in Robo Activation and Auto-inhibition Barak, Reut; Yom-Tov, Galit; Guez-Haddad, Julia Cell, Vol. 177, Issue 2 https://doi.org/10.1016/j.cell.2019.02.004	journal	April 2019
XDS Kabsch, Wolfgang Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2 https://doi.org/10.1107/S0907444909047337	journal	January 2010
Mutations in a Human ROBO Gene Disrupt Hindbrain Axon Pathway Crossing and Morphogenesis Jen, J. C. Science, Vol. 304, Issue 5676 https://doi.org/10.1126/science.1096437	journal	June 2004
Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets Alfaro, J. F.; Gong, C. -X.; Monroe, M. E. Proceedings of the National Academy of Sciences, Vol. 109, Issue 19 https://doi.org/10.1073/pnas.1200425109	journal	April 2012
MoRDa , an automatic molecular replacement pipeline Vagin, Alexey; Lebedev, Andrey Acta Crystallographica Section A Foundations and Advances, Vol. 71, Issue a1 https://doi.org/10.1107/S2053273315099672	journal	August 2015
The Crystal Structure of Netrin-1 in Complex with DCC Reveals the Bifunctionality of Netrin-1 As a Guidance Cue Finci, Lorenzo I.; Krüger, Nina; Sun, Xiaqin Neuron, Vol. 83, Issue 4 https://doi.org/10.1016/j.neuron.2014.07.010	journal	August 2014
Robo1 Forms a Compact Dimer-of-Dimers Assembly Aleksandrova, Nataliia; Gutsche, Irina; Kandiah, Eaazhisai Structure, Vol. 26, Issue 2 https://doi.org/10.1016/j.str.2017.12.003	journal	February 2018
Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects Desai, Jayashree; Shannon, Mark E.; Johnson, Mahlon D. Human Molecular Genetics, Vol. 15, Issue 8, p. 1329-1341 https://doi.org/10.1093/hmg/ddl053	journal	March 2006
Ontogeny and the possible function of a novel epidermal growth factor-like repeat domain-containing protein, NELL2, in the rat brain: A role of NELL2 in the rat brain Kim, Hyun; Ha, Chang Man; Choi, Jungil Journal of Neurochemistry, Vol. 83, Issue 6 https://doi.org/10.1046/j.1471-4159.2002.01245.x	journal	December 2002
Mechanisms and Molecules of Neuronal Wiring: A Primer Kolodkin, A. L.; Tessier-Lavigne, M. Cold Spring Harbor Perspectives in Biology, Vol. 3, Issue 6 https://doi.org/10.1101/cshperspect.a001727	journal	December 2010
Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats Watanabe, Takeshi K.; Katagiri, Toyomasa; Suzuki, Mikio Genomics, Vol. 38, Issue 3, p. 273-276 https://doi.org/10.1006/geno.1996.0628	journal	December 1996
MolProbity : all-atom structure validation for macromolecular crystallography Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042073	journal	December 2009
Evidence for the existence of two Robo3 isoforms with divergent biochemical properties Camurri, Laura; Mambetisaeva, Elvira; Davies, Derek Molecular and Cellular Neuroscience, Vol. 30, Issue 4 https://doi.org/10.1016/j.mcn.2005.07.014	journal	December 2005
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein Hu, Huaiyu Nature Neuroscience, Vol. 4, Issue 7 https://doi.org/10.1038/89482	journal	July 2001
Calculations and Publication-Quality Illustrations for Analytical Ultracentrifugation Data Brautigam, Chad A. Methods in Enzymology https://doi.org/10.1016/bs.mie.2015.05.001	book	January 2015
Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions Rubinstein, Rotem; Thu, Chan Aye; Goodman, Kerry Marie Cell, Vol. 163, Issue 3 https://doi.org/10.1016/j.cell.2015.09.026	journal	October 2015
Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains Salzman, Gabriel S.; Ackerman, Sarah D.; Ding, Chen Neuron, Vol. 91, Issue 6 https://doi.org/10.1016/j.neuron.2016.08.022	journal	September 2016
In vitro guidance of retinal axons by a tectal lamina-specific glycoprotein Nel Jiang, Yulan; Obama, Hiroya; Kuan, Soh Leh Molecular and Cellular Neuroscience, Vol. 41, Issue 2 https://doi.org/10.1016/j.mcn.2009.02.006	journal	June 2009
An Extracellular Interactome of Immunoglobulin and LRR Proteins Reveals Receptor-Ligand Networks Özkan, Engin; Carrillo, Robert A.; Eastman, Catharine L. Cell, Vol. 154, Issue 1 https://doi.org/10.1016/j.cell.2013.06.006	journal	July 2013
Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of Slit Howitt, Jason A.; Clout, Naomi J.; Hohenester, Erhard The EMBO Journal, Vol. 23, Issue 22 https://doi.org/10.1038/sj.emboj.7600446	journal	October 2004
Accurate assessment of mass, models and resolution by small-angle scattering Rambo, Robert P.; Tainer, John A. Nature, Vol. 496, Issue 7446 https://doi.org/10.1038/nature12070	journal	April 2013
slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Rothberg, J. M.; Jacobs, J. R.; Goodman, C. S. Genes & Development, Vol. 4, Issue 12a https://doi.org/10.1101/gad.4.12a.2169	journal	December 1990
Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2 Jaworski, A.; Tom, I.; Tong, R. K. Science, Vol. 350, Issue 6263 https://doi.org/10.1126/science.aad2615	journal	November 2015
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
Protocadherin cis -dimer architecture and recognition unit diversity Goodman, Kerry M.; Rubinstein, Rotem; Dan, Hanbin Proceedings of the National Academy of Sciences, Vol. 114, Issue 46 https://doi.org/10.1073/pnas.1713449114	journal	October 2017
To Cross or Not to Cross: Alternatively Spliced Forms of the Robo3 Receptor Regulate Discrete Steps in Axonal Midline Crossing Black, Douglas L.; Zipursky, S. Lawrence Neuron, Vol. 58, Issue 3 https://doi.org/10.1016/j.neuron.2008.04.019	journal	May 2008
Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance Brose, Katja; Bland, Kimberly S.; Wang, Kuan Hong Cell, Vol. 96, Issue 6 https://doi.org/10.1016/s0092-8674(00)80590-5	journal	March 1999
Conservation and divergence of axon guidance mechanisms Chisholm, Andrew; Tessier-Lavigne, Marc Current Opinion in Neurobiology, Vol. 9, Issue 5 https://doi.org/10.1016/s0959-4388(99)00021-5	journal	October 1999
Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2 Zakrys, Linas; Ward, Richard J.; Pediani, John D. Biochemical Journal, Vol. 461, Issue 1 https://doi.org/10.1042/bj20140190	journal	June 2014
Structural insight into Slit–Robo signalling Hohenester, Erhard Biochemical Society Transactions, Vol. 36, Issue 2 https://doi.org/10.1042/bst0360251	journal	March 2008
Oligomerization-induced Conformational Change in the C-terminal Region of Nel-like Molecule 1 (NELL1) Protein Is Necessary for the Efficient Mediation of Murine MC3T3-E1 Cell Adhesion and Spreading Nakamura, Yoko; Hasebe, Ai; Takahashi, Kaneyoshi Journal of Biological Chemistry, Vol. 289, Issue 14 https://doi.org/10.1074/jbc.m113.507020	journal	February 2014
A Molecular Mechanism for the Heparan Sulfate Dependence of Slit-Robo Signaling Hussain, Sadaf-Ahmahni; Piper, Michael; Fukuhara, Noémi Journal of Biological Chemistry, Vol. 281, Issue 51 https://doi.org/10.1074/jbc.m609384200	journal	October 2006
Structural and Functional Analysis of Slit and Heparin Binding to Immunoglobulin-like Domains 1 and 2 of Drosophila Robo Fukuhara, Noémi; Howitt, Jason A.; Hussain, Sadaf-Ahmahni Journal of Biological Chemistry, Vol. 283, Issue 23 https://doi.org/10.1074/jbc.m800688200	journal	March 2008
Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2 Yamamoto, Naoka; Kashiwagi, Manabu; Ishihara, Manami Journal of Biological Chemistry, Vol. 294, Issue 12 https://doi.org/10.1074/jbc.ra118.005819	journal	January 2019
Role of ROBO4 Signalling in Developmental and Pathological Angiogenesis Yadav, Suresh Singh; Narayan, Gopeshwar BioMed Research International, Vol. 2014 https://doi.org/10.1155/2014/683025	journal	January 2014
Collaborative and Specialized Functions of Robo1 and Robo2 in Spinal Commissural Axon Guidance Jaworski, A.; Long, H.; Tessier-Lavigne, M. Journal of Neuroscience, Vol. 30, Issue 28 https://doi.org/10.1523/jneurosci.6290-09.2010	journal	July 2010
Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard. Terwilliger, Thomas C.; Adams, Paul D.; Read, Randy Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.49142	text	January 2009
Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons Evans, Timothy A.; Santiago, Celine; Arbeille, Elise eLife, Vol. 4 https://doi.org/10.7554/elife.08407	journal	July 2015
Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila Cheng, Shouqiang; Ashley, James; Kurleto, Justyna D. eLife, Vol. 8 https://doi.org/10.7554/elife.41028	journal	January 2019

Cited By (91)

Functional and structural characterization of HspB1/Hsp27 from Chinese hamster ovary cells Sha, Eiryo; Nakamura, Manami; Ankai, Kazuya FEBS Open Bio, Vol. 9, Issue 10 https://doi.org/10.1002/2211-5463.12726	journal	August 2019
A General Approach to Access Morphologies of Polyoxometalates in Solution by Using SAXS: An Ab Initio Modeling Protocol Li, Mu; Wang, Weiyu; Yin, Panchao Chemistry - A European Journal, Vol. 24, Issue 25 https://doi.org/10.1002/chem.201800344	journal	April 2018
Intrinsic structural disorder of mouse proNGF Paoletti, Francesca; Covaceuszach, Sonia; Konarev, Peter V. Proteins: Structure, Function, and Bioinformatics, Vol. 75, Issue 4 https://doi.org/10.1002/prot.22311	journal	June 2009
Biochemical characterization and low-resolution SAXS structure of two-domain endoglucanase BlCel9 from Bacillus licheniformis de Araújo, Evandro Ares; de Oliveira Neto, Mário; Polikarpov, Igor Applied Microbiology and Biotechnology, Vol. 103, Issue 3 https://doi.org/10.1007/s00253-018-9508-1	journal	December 2018
WeNMR: Structural Biology on the Grid Wassenaar, Tsjerk A.; van Dijk, Marc; Loureiro-Ferreira, Nuno Journal of Grid Computing, Vol. 10, Issue 4 https://doi.org/10.1007/s10723-012-9246-z	journal	November 2012
Structural Rearrangements in the C-Terminal Domain Homolog of Orange Carotenoid Protein are Crucial for Carotenoid Transfer Harris, Dvir; Wilson, Adjele; Muzzopappa, Fernando Biophysical Journal, Vol. 116, Issue 3 https://doi.org/10.1016/j.bpj.2018.11.300	journal	February 2019
Structural peculiarities of the (MHF1-MHF2) ₄ octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: A solution SAXS study Wang, Wenjia; Guo, Qiong; Shtykova, Eleonora V. FEBS Letters, Vol. 587, Issue 18 https://doi.org/10.1016/j.febslet.2013.07.022	journal	July 2013
Structure of a Novel Dimeric SET Domain Methyltransferase that Regulates Cell Motility Pivovarova, Yulia; Liu, Jun; Lesigang, Johannes Journal of Molecular Biology, Vol. 430, Issue 21 https://doi.org/10.1016/j.jmb.2018.08.017	journal	October 2018
Structural basis for iron piracy by pathogenic Neisseria Noinaj, Nicholas; Easley, Nicole C.; Oke, Muse Nature, Vol. 483, Issue 7387 https://doi.org/10.1038/nature10823	journal	February 2012
Structural basis for the assembly of the Sxl–Unr translation regulatory complex Hennig, Janosch; Militti, Cristina; Popowicz, Grzegorz M. Nature, Vol. 515, Issue 7526 https://doi.org/10.1038/nature13693	journal	September 2014
Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex Aydin, Halil; Sultana, Azmiri; Li, Sheng Nature, Vol. 534, Issue 7608 https://doi.org/10.1038/nature18595	journal	June 2016
Structural and mechanistic insights into regulation of the retromer coat by TBC1d5 Jia, Da; Zhang, Jin-San; Li, Fang Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms13305	journal	November 2016
AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control Gersch, Malte; Famulla, Kirsten; Dahmen, Maria Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms7320	journal	February 2015
Molecular basis of human CD22 function and therapeutic targeting Ereño-Orbea, June; Sicard, Taylor; Cui, Hong Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-00836-6	journal	October 2017
A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1 Lam, Kwok-ho; Guo, Zhuojun; Krez, Nadja Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-07789-4	journal	December 2018
Unique structural features of a bacterial autotransporter adhesin suggest mechanisms for interaction with host macromolecules Paxman, Jason J.; Lo, Alvin W.; Sullivan, Matthew J. Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-09814-6	journal	April 2019
Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils Kaur, Gundeep; Kaundal, Soni; Kapoor, Srajan Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-28290-4	journal	July 2018
Molecular architecture of the Jumonji C family histone demethylase KDM5B Dorosz, Jerzy; Kristensen, Line Hyltoft; Aduri, Nanda G. Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-40573-y	journal	March 2019
Nano-encapsulated Escherichia coli Divisome Anchor ZipA, and in Complex with FtsZ Lee, Sarah C.; Collins, Richard; Lin, Yu-pin Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-54999-x	journal	December 2019
ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores Mabanglo, Mark F.; Leung, Elisa; Vahidi, Siavash Communications Biology, Vol. 2, Issue 1 https://doi.org/10.1038/s42003-019-0656-3	journal	November 2019
Structural basis of a nucleosome containing histone H2A.B/H2A.Bbd that transiently associates with reorganized chromatin Arimura, Yasuhiro; Kimura, Hiroshi; Oda, Takashi Scientific Reports, Vol. 3, Issue 1 https://doi.org/10.1038/srep03510	journal	December 2013
Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation Lawrence, Sara L.; Feil, Susanne C.; Morton, Craig J. Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep14352	journal	September 2015
Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance Barber-Zucker, Shiran; Uebe, René; Davidov, Geula Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep31933	journal	August 2016
The N-terminal domain of unknown function (DUF959) in collagen XVIII is intrinsically disordered and highly O-glycosylated Kaur, Inderjeet; Ruskamo, Salla; Koivunen, Jarkko Biochemical Journal, Vol. 475, Issue 22 https://doi.org/10.1042/bcj20180405	journal	November 2018
Conserved structure and domain organization among bacterial Slc26 transporters Compton, Emma L. R.; Page, Kimberly; Findlay, Heather E. Biochemical Journal, Vol. 463, Issue 2 https://doi.org/10.1042/BJ20130619	journal	September 2014
Light-activated DNA binding in a designed allosteric protein Strickland, D.; Moffat, K.; Sosnick, T. R. Proceedings of the National Academy of Sciences, Vol. 105, Issue 31, p. 10709-10714 https://doi.org/10.1073/pnas.0709610105	journal	July 2008
The human IgM pentamer is a mushroom-shaped molecule with a flexural bias Czajkowsky, D. M.; Shao, Z. Proceedings of the National Academy of Sciences, Vol. 106, Issue 35 https://doi.org/10.1073/pnas.0903805106	journal	August 2009
Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS Sun, Litao; Song, Youngzee; Blocquel, David Proceedings of the National Academy of Sciences, Vol. 113, Issue 50 https://doi.org/10.1073/pnas.1617316113	journal	November 2016
How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans Cartmell, Alan; Lowe, Elisabeth C.; Baslé, Arnaud Proceedings of the National Academy of Sciences, Vol. 114, Issue 27 https://doi.org/10.1073/pnas.1704367114	journal	June 2017
DC-SIGN Neck Domain Is a pH-sensor Controlling Oligomerization: SAXS AND HYDRODYNAMIC STUDIES OF EXTRACELLULAR DOMAIN Tabarani, Georges; Thépaut, Michel; Stroebel, David Journal of Biological Chemistry, Vol. 284, Issue 32 https://doi.org/10.1074/jbc.m109.021204	journal	June 2009
Electrostatic Interactions Involving the Extreme C Terminus of Nuclear Export Factor CRM1 Modulate Its Affinity for Cargo Fox, Abigail M.; Ciziene, Danguole; McLaughlin, Stephen H. Journal of Biological Chemistry, Vol. 286, Issue 33 https://doi.org/10.1074/jbc.M111.245092	journal	August 2011
Fission Yeast Swi5-Sfr1 Protein Complex, an Activator of Rad51 Recombinase, Forms an Extremely Elongated Dogleg-shaped Structure Kokabu, Yuichi; Murayama, Yasuto; Kuwabara, Naoyuki Journal of Biological Chemistry, Vol. 286, Issue 50 https://doi.org/10.1074/jbc.m111.303339	journal	December 2011
Interaction of the HIV-1 Intasome with Transportin 3 Protein (TNPO3 or TRN-SR2) Larue, Ross; Gupta, Kushol; Wuensch, Christiane Journal of Biological Chemistry, Vol. 287, Issue 41 https://doi.org/10.1074/jbc.M112.384669	journal	October 2012
Characterization of Enzymes from Legionella pneumophila Involved in Reversible Adenylylation of Rab1 Protein Müller, Matthias P.; Shkumatov, Alexander V.; Oesterlin, Lena K. Journal of Biological Chemistry, Vol. 287, Issue 42 https://doi.org/10.1074/jbc.m112.396861	journal	October 2012
Differential Role of HAMP-like Linkers in Regulating the Functionality of the Group III Histidine Kinase DhNik1p Kaur, Harsimran; Singh, Shikha; Rathore, Yogendra S. Journal of Biological Chemistry, Vol. 289, Issue 29 https://doi.org/10.1074/jbc.M114.554303	journal	July 2014
Assembly of the Respiratory Mucin MUC5B Ridley, Caroline; Kouvatsos, Nikos; Raynal, Bertrand D. Journal of Biological Chemistry, Vol. 289, Issue 23 https://doi.org/10.1074/jbc.m114.566679	journal	June 2014
Structural Basis for Oxygen Activation at a Heterodinuclear Manganese/Iron Cofactor Griese, Julia J.; Kositzki, Ramona; Schrapers, Peer Journal of Biological Chemistry, Vol. 290, Issue 42 https://doi.org/10.1074/jbc.M115.675223	journal	October 2015
Solution Conformation and Thermodynamic Characteristics of RNA Binding by the Splicing Factor U2AF ⁶⁵ Jenkins, Jermaine L.; Shen, Haihong; Green, Michael R. Journal of Biological Chemistry, Vol. 283, Issue 48 https://doi.org/10.1074/jbc.M806297200	journal	October 2008
Structure-specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones Marcianò, Gabriele; Da Vela, Stefano; Tria, Giancarlo Journal of Biological Chemistry, Vol. 293, Issue 26 https://doi.org/10.1074/jbc.ra117.000994	journal	June 2018
The antibiotic cyclomarin blocks arginine-phosphate–induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis Weinhäupl, Katharina; Brennich, Martha; Kazmaier, Uli Journal of Biological Chemistry, Vol. 293, Issue 22 https://doi.org/10.1074/jbc.ra118.002251	journal	June 2018
Direct observation of conformational dynamics of the PH domain in phospholipases Cɛ and β may contribute to subfamily-specific roles in regulation Garland-Kuntz, Elisabeth E.; Vago, Frank S.; Sieng, Monita Journal of Biological Chemistry, Vol. 293, Issue 45 https://doi.org/10.1074/jbc.ra118.003656	journal	November 2018
The dimeric ectodomain of the alkali-sensing insulin receptor–related receptor (ectoIRR) has a droplike shape Shtykova, Eleonora V.; Petoukhov, Maxim V.; Mozhaev, Andrey A. Journal of Biological Chemistry, Vol. 294, Issue 47 https://doi.org/10.1074/jbc.RA119.010390	journal	November 2019
Integrative Structure–Function Mapping of the Nucleoporin Nup133 Suggests a Conserved Mechanism for Membrane Anchoring of the Nuclear Pore Complex Kim, Seung Joong; Fernandez-Martinez, Javier; Sampathkumar, Parthasarathy Molecular & Cellular Proteomics, Vol. 13, Issue 11 https://doi.org/10.1074/mcp.m114.040915	journal	August 2014
Disease-associated mutations alter the dynamic motion of the N-terminal domain of the human cardiac ryanodine receptor Bauer, Jacob A.; Borko, Ľubomír; Pavlović, Jelena Journal of Biomolecular Structure and Dynamics https://doi.org/10.1080/07391102.2019.1600027	journal	March 2019
Simple rules for passive diffusion through the nuclear pore complex Timney, Benjamin L.; Raveh, Barak; Mironska, Roxana The Journal of Cell Biology, Vol. 215, Issue 1 https://doi.org/10.1083/jcb.201601004	journal	October 2016
Structural evaluation of an amyloid fibril model using small-angle x-ray scattering Dahal, Eshan; Choi, Mina; Alam, Nadia Physical Biology, Vol. 14, Issue 4 https://doi.org/10.1088/1478-3975/aa776a	journal	June 2017
Calcium-dependent structural changes in human reticulocalbin-1 Suzuki, N.; Ban, S.; Itoh, E. Journal of Biochemistry, Vol. 155, Issue 5 https://doi.org/10.1093/jb/mvu003	journal	January 2014
Quaternary structure of the yeast Arc1p-aminoacyl-tRNA synthetase complex in solution and its compaction upon binding of tRNAs Koehler, Christine; Round, Adam; Simader, Hannes Nucleic Acids Research, Vol. 41, Issue 1 https://doi.org/10.1093/nar/gks1072	journal	November 2012
The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1 helicase-like motor Toliusis, Paulius; Tamulaitiene, Giedre; Grigaitis, Rokas Nucleic Acids Research, Vol. 46, Issue 5 https://doi.org/10.1093/nar/gky107	journal	February 2018
Structure of human telomere G-quadruplex in the presence of a model drug along the thermal unfolding pathway Bianchi, Federico; Comez, Lucia; Biehl, Ralf Nucleic Acids Research, Vol. 46, Issue 22 https://doi.org/10.1093/nar/gky1092	journal	November 2018
Structure and hydrodynamics of a DNA G-quadruplex with a cytosine bulge Meier, Markus; Moya-Torres, Aniel; Krahn, Natalie J. Nucleic Acids Research, Vol. 46, Issue 10 https://doi.org/10.1093/nar/gky307	journal	May 2018
Microstructural degeneracy associated with a two-point correlation function and its information content Gommes, C. J.; Jiao, Y.; Torquato, S. Physical Review E, Vol. 85, Issue 5 https://doi.org/10.1103/PhysRevE.85.051140	journal	May 2012
Combination of X-ray crystallography, SAXS and DEER to obtain the structure of the FnIII-3,4 domains of integrin α6β4 Alonso-García, Noelia; García-Rubio, Inés; Manso, José A. Acta Crystallographica Section D Biological Crystallography, Vol. 71, Issue 4 https://doi.org/10.1107/s1399004715002485	journal	March 2015
Interpretation of solution scattering data from lipid nanodiscs Graziano, Vito; Miller, Lisa; Yang, Lin Journal of Applied Crystallography, Vol. 51, Issue 1 https://doi.org/10.1107/s1600576717018441	journal	February 2018
Photocage-initiated time-resolved solution X-ray scattering investigation of protein dimerization Josts, Inokentijs; Niebling, Stephan; Gao, Yunyun IUCrJ, Vol. 5, Issue 6 https://doi.org/10.1107/S2052252518012149	journal	September 2018
The structure of VgrG1 from Pseudomonas aeruginosa , the needle tip of the bacterial type VI secretion system Spínola-Amilibia, Mercedes; Davó-Siguero, Irene; Ruiz, Federico M. Acta Crystallographica Section D Structural Biology, Vol. 72, Issue 1 https://doi.org/10.1107/S2059798315021142	journal	January 2016
Structural insights into the interaction of the conserved mammalian proteins GAPR-1 and Beclin 1, a key autophagy protein Li, Yue; Zhao, Yuting; Su, Minfei Acta Crystallographica Section D Structural Biology, Vol. 73, Issue 9 https://doi.org/10.1107/S2059798317011822	journal	August 2017
Solution structures of long-acting insulin analogues and their complexes with albumin Ryberg, Line A.; Sønderby, Pernille; Barrientos, Fabian International Union of Crystallography (IUCr) https://doi.org/10.1107/s2059798318017552/jc5021sup1.pdf	text	January 2019
Flexibility of truncated and full-length glucansucrase GTF180 enzymes from Lactobacillus reuteri 180 Pijning, Tjaard; Vujičić-Žagar, Andreja; Kralj, Slavko FEBS Journal, Vol. 281, Issue 9 https://doi.org/10.1111/febs.12769	journal	March 2014
Borrelia outer surface protein C is capable of human fibrinogen binding Bierwagen, Paulina; Szpotkowski, Kamil; Jaskolski, Mariusz The FEBS Journal, Vol. 286, Issue 12 https://doi.org/10.1111/febs.14810	journal	March 2019
A biophysical and structural study of two chitinases from Agave tequilana and their potential role as defense proteins Sierra‐Gómez, Yusvel; Rodríguez‐Hernández, Annia; Cano‐Sánchez, Patricia The FEBS Journal, Vol. 286, Issue 23 https://doi.org/10.1111/febs.14993	journal	July 2019
GGA Autoinhibition Revisited Cramer, Jacob F.; Gustafsen, Camilla; Behrens, Manja A. Traffic, Vol. 11, Issue 2 https://doi.org/10.1111/j.1600-0854.2009.01017.x	journal	February 2010
Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination Dueber, E. C.; Schoeffler, A. J.; Lingel, A. Science, Vol. 334, Issue 6054 https://doi.org/10.1126/science.1207862	journal	October 2011
Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor Williams, S. J.; Sohn, K. H.; Wan, L. Science, Vol. 344, Issue 6181 https://doi.org/10.1126/science.1247357	journal	April 2014
Solution Structure, Self-Assembly, and Membrane Interactions of the Matrix Protein from Newcastle Disease Virus at Neutral and Acidic pH Shtykova, E. V.; Petoukhov, M. V.; Dadinova, L. A. Journal of Virology, Vol. 93, Issue 6 https://doi.org/10.1128/jvi.01450-18	journal	March 2019
Molecular Basis of Unusually High Neutralization Resistance in Tier 3 HIV-1 Strain 253-11 Moyo, Thandeka; Ereño-Orbea, June; Jacob, Rajesh Abraham Journal of Virology, Vol. 92, Issue 14 https://doi.org/10.1128/jvi.02261-17	journal	April 2018
Структура частиц белка оболочки А вируса картофеля и их диссоциация Ксенофонтов, А. Л.; Добров, Е. Н.; Федорова, Н. В. Молекулярная биология, Vol. 52, Issue 6 https://doi.org/10.1134/S0026898418060101	journal	January 2018
High-resolution structure of a type IV pilin from the metal-reducing bacterium Shewanella oneidensis Gorgel, Manuela; Ulstrup, Jakob Jensen; Bøggild, Andreas BMC Structural Biology, Vol. 15, Issue 1 https://doi.org/10.1186/s12900-015-0031-7	journal	February 2015
The mechanism by which a distinguishing arabinofuranosidase can cope with internal di-substitutions in arabinoxylans dos Santos, Camila Ramos; de Giuseppe, Priscila Oliveira; de Souza, Flávio Henrique Moreira Biotechnology for Biofuels, Vol. 11, Issue 1 https://doi.org/10.1186/s13068-018-1212-y	journal	August 2018
Domain Swapping and Different Oligomeric States for the Complex Between Calmodulin and the Calmodulin-Binding Domain of Calcineurin A Majava, Viivi; Kursula, Petri PLoS ONE, Vol. 4, Issue 4 https://doi.org/10.1371/journal.pone.0005402	journal	April 2009
Structural Insights into the Mechanism of Phosphoregulation of the Retinoblastoma Protein Lamber, Ekaterina P.; Beuron, Fabienne; Morris, Edward P. PLoS ONE, Vol. 8, Issue 3 https://doi.org/10.1371/journal.pone.0058463	journal	March 2013
Low Resolution Structural Studies Indicate that the Activator of Hsp90 ATPase 1 (Aha1) of Leishmania braziliensis Has an Elongated Shape Which Allows Its Interaction with Both N- and M-Domains of Hsp90 Seraphim, Thiago V.; Alves, Marina M.; Silva, Indjara M. PLoS ONE, Vol. 8, Issue 6 https://doi.org/10.1371/journal.pone.0066822	journal	June 2013
Structural Analysis of Influenza A Virus Matrix Protein M1 and Its Self-Assemblies at Low pH Shtykova, Eleonora V.; Baratova, Lyudmila A.; Fedorova, Natalia V. PLoS ONE, Vol. 8, Issue 12 https://doi.org/10.1371/journal.pone.0082431	journal	December 2013
An alkaline active feruloyl-CoA synthetase from soil metagenome as a potential key enzyme for lignin valorization strategies Sodré, Victoria; Araujo, Juscemácia Nascimento; Gonçalves, Thiago Augusto PLOS ONE, Vol. 14, Issue 2 https://doi.org/10.1371/journal.pone.0212629	journal	February 2019
The Vibrio cholerae Colonization Factor GbpA Possesses a Modular Structure that Governs Binding to Different Host Surfaces Wong, Edmond; Vaaje-Kolstad, Gustav; Ghosh, Avishek PLoS Pathogens, Vol. 8, Issue 1 https://doi.org/10.1371/journal.ppat.1002373	journal	January 2012
Lectin-Like Bacteriocins from Pseudomonas spp. Utilise D-Rhamnose Containing Lipopolysaccharide as a Cellular Receptor McCaughey, Laura C.; Grinter, Rhys; Josts, Inokentijs PLoS Pathogens, Vol. 10, Issue 2 https://doi.org/10.1371/journal.ppat.1003898	journal	February 2014
Long non‐coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution Zhang, Yupeng; Zhang, Yikan; Liu, Zhong‐Yu EMBO reports, Vol. 20, Issue 11 https://doi.org/10.15252/embr.201847016	journal	September 2019
Maturation of 6S regulatory RNA to a highly elongated structure Fadouloglou, Vasiliki; Lin, Hong-Tin; Tria, Giancarlo Deutsches Elektronen-Synchrotron, DESY, Hamburg https://doi.org/10.3204/pubdb-2016-00780	text	January 2015
Structural and Dynamics Studies of a Truncated Variant of CI Repressor From Bacteriophage TP901-1 Rasmussen, Kim Krighaar; Frandsen, Kristian E. H.; Boeri Erba, Elisabetta Deutsches Elektronen-Synchrotron, DESY, Hamburg https://doi.org/10.3204/pubdb-2016-02731	text	January 2016
The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053 Albesa-Jové, David; Comino, Natalia; Tersa, Montse Deutsches Elektronen-Synchrotron, DESY, Hamburg https://doi.org/10.3204/pubdb-2016-04571	text	January 2015
X-Ray Solution Scattering Study of Four Escherichia coli Enzymes Involved in Stationary-Phase Metabolism Dadinova, Liubov A.; Shtykova, Eleonora V.; Konarev, Petr V. Deutsches Elektronen-Synchrotron, DESY, Hamburg https://doi.org/10.3204/pubdb-2017-00416	text	January 2016
VirB8-like protein TraH is crucial for DNA transfer in Enterococcus faecalis Fercher, Christian; Probst, Ines; Kohler, Verena Deutsches Elektronen-Synchrotron, DESY, Hamburg https://doi.org/10.3204/pubdb-2017-00434	text	January 2016
Myelin 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase: Active-Site Ligand Binding and Molecular Conformation Myllykoski, Matti; Raasakka, Arne; Han, Huijong Deutsches Elektronen-Synchrotron, DESY, Hamburg https://doi.org/10.3204/pubdb-2017-05054	text	January 2012
Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1 Alblova, Miroslava; Smidova, Aneta; Docekal, Vojtech Deutsches Elektronen-Synchrotron, DESY, Hamburg https://doi.org/10.3204/pubdb-2017-12382	text	January 2017
SAXS and stability studies of iron-induced oligomers of bacterial frataxin CyaY Fekry, Mostafa; Alshokry, Wessen; Grela, Przemysław Deutsches Elektronen-Synchrotron, DESY, Hamburg https://doi.org/10.3204/pubdb-2017-14027	text	January 2017
Conformational characterization of full-length X-chromosome-linked inhibitor of apoptosis protein (XIAP) through an integrated approach Polykretis, Panagis; Luchinat, Enrico; Bonucci, Alessio Deutsches Elektronen-Synchrotron, DESY, Hamburg https://doi.org/10.3204/pubdb-2019-03571	text	January 2019
Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology White, Mark Andrew; Tsalkova, Tamara; Mei, Fang C. Cells, Vol. 9, Issue 1 https://doi.org/10.3390/cells9010035	journal	December 2019
Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action Rosa, Brenda; Marchetti, Marialaura; Paredi, Gianluca International Journal of Molecular Sciences, Vol. 20, Issue 20 https://doi.org/10.3390/ijms20205219	journal	October 2019
Review of the fundamental theories behind small angle X-ray scattering, molecular dynamics simulations, and relevant integrated application Boldon, Lauren; Laliberte, Fallon; Liu, Li Nano Reviews, Vol. 6, Issue 1 https://doi.org/10.3402/nano.v6.25661	journal	January 2015
Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis Bolduc, David; Rahdar, Meghdad; Tu-Sekine, Becky eLife, Vol. 2 https://doi.org/10.7554/elife.00691	journal	July 2013
Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone Padavannil, Abhilash; Sarkar, Prithwijit; Kim, Seung Joong eLife, Vol. 8 https://doi.org/10.7554/eLife.43630	journal	March 2019

Similar Records

Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment

Journal Article · Mon Jul 25 00:00:00 EDT 2016 · Nature Communications · OSTI ID:1608059

Chung, Peter J.; Song, Chaeyeon; Deek, Joanna; +6 more

Structure and Activity of the Axon Guidance Protein MICAL

Journal Article · Sat Jan 01 00:00:00 EST 2005 · Proc Natl Acad Sci USA · OSTI ID:1608059

Nadella, M; Bianchet, M; Gabelli, S; +2 more

Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence

Journal Article · Wed May 01 00:00:00 EDT 2019 · Proceedings of the National Academy of Sciences of the United States of America · OSTI ID:1608059

Cheng, Shouqiang; Park, Yeonwoo; Kurleto, Justyna D.; +4 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES

Title: NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance

Citation Formats

References (68)

Cited By (91)

Similar Records

Related Subjects