Compositions and methods for the delivery of oxygen

Cary, Stephen P. L.; Boon, Elizabeth M.; Weinert, Emily; Winger, Jonathan A.; Marletta, Michael A.

Title: Compositions and methods for the delivery of oxygen

Patent · Tue Feb 12 00:00:00 EST 2019

OSTI ID:1502841

Cary, Stephen P. L.; Boon, Elizabeth M.; Weinert, Emily; Winger, Jonathan A.; Marletta, Michael A.

H--NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O.sub.2 delivery. The engineered H--NOX proteins comprise mutations that impart altered O.sub.2 or NO ligand-binding relative to the corresponding wild-type H--NOX domain, and are operative as physiologically compatible mammalian blood O.sub.2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H--NOX proteins for the treatment of any condition for which delivery of O.sub.2 is beneficial.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 10,202,428

Application Number:: 15/292,012

OSTI ID:: 1502841

Resource Relation:: Patent File Date: 2016 Oct 12

Country of Publication:: United States

Language:: English

References (101)

Model of nitric oxide diffusion in an arteriole: impact of hemoglobin-based blood substitutes Kavdia, Mahendra; Tsoukias, Nikolaos M.; Popel, Aleksander S. American Journal of Physiology-Heart and Circulatory Physiology, Vol. 282, Issue 6 https://doi.org/10.1152/ajpheart.00972.2001	journal	June 2002
The Toxicities of Native and Modified Hemoglobins Everse, Johannes; Hsia, Nelson Free Radical Biology and Medicine, Vol. 22, Issue 6 https://doi.org/10.1016/S0891-5849(96)00499-6	journal	January 1997
Methods and compositions for optimization of oxygen transport by cell-free systems Winslow, Robert M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6432918 US Patent Document 6,432,918	patent	August 2002
Process for site specific mutagenesis without phenotypic selection Kunkel, Thomas https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4873192 US Patent Document 4,873,192	patent	October 1989
Effects of recombinant-hemoglobin solutions rHb2.0 and rHb1.1 on blood pressure, intestinal blood flow, and gut oxygenation in a rat model of hemorrhagic shock Raat, Nicolaas J. H.; Liu, Jing-Feng; Doyle, Michael P. Journal of Laboratory and Clinical Medicine, Vol. 145, Issue 1 https://doi.org/10.1016/j.lab.2004.05.017	journal	January 2005
Ligand specificity of H-NOX domains: from sGC to bacterial NO sensors Boon, Elizabeth M.; Marletta, Michael A. Journal of Inorganic Biochemistry, Vol. 99, Issue 4 https://doi.org/10.1016/j.jinorgbio.2004.12.016	journal	April 2005
Compositions and methods for the delivery of oxygen Cary, Stephen P. L.; Boon, Elizabeth M.; Weinert, Emily https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8404631 US Patent Document 8,404,631	patent	March 2013
Effect of prolonged nitrate therapy on left ventricular remodeling after canine acute myocardial infarction. Jugdutt, B. I.; Khan, M. I. Circulation, Vol. 89, Issue 5 https://doi.org/10.1161/01.CIR.89.5.2297	journal	May 1994
Compositions and methods for the delivery of nitric oxide Cary, Stephen P. L.; Boon, Elizabeth M.; Winger, Jonathan A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8404632 US Patent Document 8,404,632	patent	March 2013
A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85 Overgaard, Jens; Sand Hansen, Hanne; Overgaard, Marie Radiotherapy and Oncology, Vol. 46, Issue 2 https://doi.org/10.1016/S0167-8140(97)00220-X	journal	February 1998
Cooperativity in the dissociation of nitric oxide from hemoglobin. Moore, E. G.; Gibson, Q. H. Journal of Biological Chemistry, Vol. 251, Issue 9 https://doi.org/10.1016/S0021-9258(17)33557-3	journal	May 1976
Effect of Intermittent Administration of Sustained Release Isosorbide Dinitrate (sr-ISDN) in Rats with Pressure-Overload Heart Shimamura, Shunsuke; Endo, Hayato; Kutsuna, Hiromi Journal of Veterinary Medical Science, Vol. 68, Issue 3 https://doi.org/10.1292/jvms.68.213	journal	January 2006
Targeted Oxygen Delivery within Hepatic Hollow Fiber Bioreactors via Supplementation of Hemoglobin-Based Oxygen Carriers Sullivan, Jesse P.; Palmer, Andre F. Biotechnology Progress, Vol. 22, Issue 5 https://doi.org/10.1021/bp0600684	journal	January 2006
Current status of oxygen carriers ('blood substitutes'): 2006 Winslow, R. M. Vox Sanguinis, Vol. 91, Issue 2 https://doi.org/10.1111/j.1423-0410.2006.00789.x	journal	August 2006
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases Pellicena, P.; Karow, D. S.; Boon, E. M. Proceedings of the National Academy of Sciences, Vol. 101, Issue 35 https://doi.org/10.1073/pnas.0405188101	journal	August 2004
Oxygen carriers: A selected review Inayat, Mohammed S.; Bernard, Andrew C.; Gallicchio, Vincent S. Transfusion and Apheresis Science, Vol. 34, Issue 1 https://doi.org/10.1016/j.transci.2005.09.005	journal	February 2006
Effects of recombinant-hemoglobin solutions rHb2.0 and rHb1.1 on blood pressure, intestinal blood flow, and gut oxygenation in a rat model of hemorrhagic shock Raat, N. J. H. Journal of Laboratory and Clinical Medicine, Vol. 146, Issue 5 https://doi.org/10.1016/j.lab.2005.07.011	journal	November 2005
ARCON: a novel biology-based approach in radiotherapy Kaanders, Johannes HAM; Bussink, Johan; van der Kogel, Albert J. The Lancet Oncology, Vol. 3, Issue 12 https://doi.org/10.1016/S1470-2045(02)00929-4	journal	December 2002
Rate of NO scavenging alters effects of recombinant hemoglobin solutions on pulmonary vasoreactivity Resta, Thomas C.; Walker, Benjimen R.; Eichinger, Mark R. Journal of Applied Physiology, Vol. 93, Issue 4 https://doi.org/10.1152/japplphysiol.00175.2002	journal	October 2002
Red Cell Substitutes Winslow, Robert M. Seminars in Hematology, Vol. 44, Issue 1 https://doi.org/10.1053/j.seminhematol.2006.09.013	journal	January 2007
A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia George, Isaac; Yi, Geng-Hua; Schulman, Allison R. American Journal of Physiology-Heart and Circulatory Physiology, Vol. 291, Issue 3 https://doi.org/10.1152/ajpheart.00076.2006	journal	September 2006
An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence. Vanderkooi, J. M.; Maniara, G.; Green, T. J. Journal of Biological Chemistry, Vol. 262, Issue 12 https://doi.org/10.1016/S0021-9258(18)45596-2	journal	April 1987
Inhibition of restriction endonuclease Nel I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis Nakamaye, Kay L.; Eckstein, Fritz Nucleic Acids Research, Vol. 14, Issue 24 https://doi.org/10.1093/nar/14.24.9679	journal	January 1986
The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA Taylor, W. John; Ott, Johann; Eckstein, Fritz Nucleic Acids Research, Vol. 13, Issue 24 https://doi.org/10.1093/nar/13.24.8765	journal	January 1985
RSR13 Plus Cranial Radiation Therapy in Patients With Brain Metastases: Comparison With the Radiation Therapy Oncology Group Recursive Partitioning Analysis Brain Metastases Database Shaw, Edward; Scott, Charles; Suh, John Journal of Clinical Oncology, Vol. 21, Issue 12 https://doi.org/10.1200/JCO.2003.08.116	journal	June 2003
Scheduling of Radiation with Angiogenesis Inhibitors Anginex and Avastin Improves Therapeutic Outcome via Vessel Normalization Dings, R. P. M.; Loren, M.; Heun, H. Clinical Cancer Research, Vol. 13, Issue 11 https://doi.org/10.1158/1078-0432.CCR-06-2441	journal	June 2007
The mechanism of action of radiosensitization of conventional chemotherapeutic agents Lawrence, Theodore S.; Blackstock, A. William; McGinn, Cornelius Seminars in Radiation Oncology, Vol. 13, Issue 1 https://doi.org/10.1053/srao.2003.50002	journal	January 2003
Blood substitutes Habib, Fahim A.; Cohn, Stephen M. Current Opinion in Anaesthesiology, Vol. 17, Issue 2 https://doi.org/10.1097/00001503-200404000-00009	journal	January 2004
Role of Binding Site Loops in Controlling Nitric Oxide Release: Structure and Kinetics of Mutant Forms of Nitrophorin 4 ^† ^, ^‡ Maes, Estelle M.; Weichsel, Andrzej; Andersen, John F. Biochemistry, Vol. 43, Issue 21 https://doi.org/10.1021/bi049748a	journal	June 2004
Resonance Raman and Ligand Binding Studies of the Oxygen-sensing Signal Transducer Protein HemAT from Bacillus subtilis Aono, Shigetoshi; Kato, Toshiyuki; Matsuki, Mayumi Journal of Biological Chemistry, Vol. 277, Issue 16 https://doi.org/10.1074/jbc.M112256200	journal	January 2002
The effect of combined nicotinamide and carbogen treatments in human tumour xenografts: oxygenation and tumour control studies Stüben, Georg; Stuschke, Martin; Knühmann, Kai Radiotherapy and Oncology, Vol. 48, Issue 2 https://doi.org/10.1016/S0167-8140(98)00006-1	journal	August 1998
Lessons from phase III clinical trials on anti-VEGF therapy for cancer Jain, Rakesh K.; Duda, Dan G.; Clark, Jeffrey W. Nature Clinical Practice Oncology, Vol. 3, Issue 1 https://doi.org/10.1038/ncponc0403	journal	January 2006
Mechanisms of Ligand Recognition in Myoglobin Springer, Barry A.; Sligar, Stephen G.; Olson, John S. Chemical Reviews, Vol. 94, Issue 3 https://doi.org/10.1021/cr00027a007	journal	May 1994
Multiple sequence alignment with hierarchical clustering Corpet, F. Nucleic Acids Research, Vol. 16, Issue 22, p. 10881-10890 https://doi.org/10.1093/nar/16.22.10881	journal	November 1988
The role of diffusion in limiting the rate of ligand binding to hemoglobin. Morris, R. J.; Gibson, Q. H. Journal of Biological Chemistry, Vol. 255, Issue 17 https://doi.org/10.1016/S0021-9258(19)70604-8	journal	September 1980
A Phase I study of RSR13, a radiation-enhancing hemoglobin modifier: tolerance of repeated intravenous doses and correlation of pharmacokinetics with pharmacodynamics Kavanagh, Brian D.; Khandelwal, Shiv R.; Schmidt-Ullrich, Rupert K. International Journal of Radiation OncologyBiologyPhysics, Vol. 49, Issue 4 https://doi.org/10.1016/S0360-3016(00)01532-7	journal	March 2001
Identification of residues crucially involved in soluble guanylate cyclase activation Rothkegel, Christiane; Schmidt, Peter M.; Stoll, Friederike FEBS Letters, Vol. 580, Issue 17 https://doi.org/10.1016/j.febslet.2006.06.079	journal	July 2006
Osmotic effects of polyethylene glycol Schiller, Lawrence R.; Emmett, Michael; Santa Ana, Carol A. Gastroenterology, Vol. 94, Issue 4 https://doi.org/10.1016/0016-5085(88)90550-1	journal	April 1988
The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA Taylor, John W.; Schmidt, Walter; Cosstick, Richard Nucleic Acids Research, Vol. 13, Issue 24 https://doi.org/10.1093/nar/13.24.8749	journal	January 1985
Sensitive and Selective Detection of Nitric Oxide Using an H−NOX Domain Boon, Elizabeth M.; Marletta, Michael A. Journal of the American Chemical Society, Vol. 128, Issue 31 https://doi.org/10.1021/ja0632714	journal	August 2006
A molecular basis for NO selectivity in soluble guanylate cyclase Boon, Elizabeth M.; Huang, Shirley H.; Marletta, Michael A. Nature Chemical Biology, Vol. 1, Issue 1 https://doi.org/10.1038/nchembio704	journal	May 2005
Recombinant Human Hemoglobin with Reduced Nitric Oxide–scavenging Capacity Restores Effectively Pancreatic Microcirculatory Disorders in Hemorrhagic Shock von Dobschuetz, Ernst; Hutter, Joerg; Hoffmann, Tomas Anesthesiology, Vol. 100, Issue 6 https://doi.org/10.1097/00000542-200406000-00021	journal	January 2004
Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin Doherty, Daniel H.; Doyle, Michael P.; Curry, Shawn R. Nature Biotechnology, Vol. 16, Issue 7 https://doi.org/10.1038/nbt0798-672	journal	July 1998
Comparison of PEG-modified albumin and hemoglobin in extreme hemodilution in the rat Winslow, Robert M.; Lohman, Jeff; Malavalli, Ashok Journal of Applied Physiology, Vol. 97, Issue 4 https://doi.org/10.1152/japplphysiol.00404.2004	journal	October 2004
Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging Weickert, Michael J.; Glascock, Christopher B.; Mathews, Antony J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6455676 US Patent Document 6,455,676	patent	September 2002
A molecular basis for nitric oxide sensing by soluble guanylate cyclase Zhao, Y.; Brandish, P. E.; Ballou, D. P. Proceedings of the National Academy of Sciences, Vol. 96, Issue 26 https://doi.org/10.1073/pnas.96.26.14753	journal	December 1999
Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue Gray, Jesse M.; Karow, David S.; Lu, Hang Nature, Vol. 430, Issue 6997 https://doi.org/10.1038/nature02714	journal	June 2004
Tirapazamine Plus Cisplatin Versus Cisplatin in Advanced Non–Small-Cell Lung Cancer: A Report of the International CATAPULT I Study Group von Pawel, Joachim; von Roemeling, Reinhard; Gatzemeier, Ulrich Journal of Clinical Oncology, Vol. 18, Issue 6 https://doi.org/10.1200/JCO.2000.18.6.1351	journal	March 2000
Mechanism of NO-Induced Oxidation of Myoglobin and Hemoglobin ^† Eich, Raymund F.; Li, Tiansheng; Lemon, Douglas D. Biochemistry, Vol. 35, Issue 22 https://doi.org/10.1021/bi960442g	journal	January 1996
Mutant recombinant hemoglobins containing heme pocket mutations Olson, John S.; Mathews, Antony J.; Aitken, Jacqueline F. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6022849 US Patent Document 6,022,849	patent	February 2000
Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers Migita, Russell; Gonzales, Armando; Gonzales, Maria L. Journal of Applied Physiology, Vol. 82, Issue 6 https://doi.org/10.1152/jappl.1997.82.6.1995	journal	June 1997
Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP Cary, S. P. L.; Winger, J. A.; Marletta, M. A. Proceedings of the National Academy of Sciences, Vol. 102, Issue 37 https://doi.org/10.1073/pnas.0506289102	journal	August 2005
RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice Khandelwal, S. R.; Kavanagh, B. D.; Lin, P-S British Journal of Cancer, Vol. 79, Issue 5-6 https://doi.org/10.1038/sj.bjc.6690130	journal	January 1999
Nitric-Oxide Releasing Molecules : A New Class of Drugs with Several Major Indications Burgaud, J.; Riffaud, J.; Soldato, P. Current Pharmaceutical Design, Vol. 8, Issue 3 https://doi.org/10.2174/1381612023396357	journal	February 2002
Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas Lee, Ding-Jen; Cosmatos, Dennis; Marcial, Victor A. International Journal of Radiation OncologyBiologyPhysics, Vol. 32, Issue 3 https://doi.org/10.1016/0360-3016(95)00150-W	journal	June 1995
Site-directed mutagenesis of herpesvirus glycoprotein phosphorylation sites by recombination polymerase chain reaction. Yao, Z.; Jones, D. H.; Grose, C. Genome Research, Vol. 1, Issue 3 https://doi.org/10.1101/gr.1.3.205	journal	February 1992
Methods and compositions for optimization of oxygen transport by cell-free systems Winslow, Robert M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6054427 US Patent Document 6,054,427	patent	April 2000
Rapid and efficient site-specific mutagenesis without phenotypic selection. Kunkel, T. A. Proceedings of the National Academy of Sciences, Vol. 82, Issue 2, p. 488-492 https://doi.org/10.1073/pnas.82.2.488	journal	January 1985
Heme-Based Sensors, Exemplified by the Kinase FixL, Are a New Class of Heme Protein with Distinctive Ligand Binding and Autoxidation Gilles-Gonzalez, Marie A.; Gonzalez, Gonzalo; Perutz, Max F. Biochemistry, Vol. 33, Issue 26 https://doi.org/10.1021/bi00192a011	journal	July 1994
Kinetics of Nitric Oxide Dissociation from Five- and Six-Coordinate Nitrosyl Hemes and Heme Proteins, Including Soluble Guanylate Cyclase ^† Kharitonov, Vladimir G.; Sharma, Vijay S.; Magde, Douglas Biochemistry, Vol. 36, Issue 22 https://doi.org/10.1021/bi970201o	journal	June 1997
Artificial O2 Carriers: Status in 2005 Spahn, Donat; Kocian, Roman Current Pharmaceutical Design, Vol. 11, Issue 31 https://doi.org/10.2174/138161205774913354	journal	December 2005
Phase III Trial of Paclitaxel Plus Carboplatin With or Without Tirapazamine in Advanced Non–Small-Cell Lung Cancer: Southwest Oncology Group Trial S0003 Williamson, Stephen K.; Crowley, John J.; Lara, Primo N. Journal of Clinical Oncology, Vol. 23, Issue 36 https://doi.org/10.1200/JCO.2005.01.3771	journal	December 2005
Impact of Tumor Hypoxia and Anemia on Radiation Therapy Outcomes Harrison, L. B. The Oncologist, Vol. 7, Issue 6 https://doi.org/10.1634/theoncologist.7-6-492	journal	December 2002
Comparison of the enhancement of tumor responses to fractionated irradiation by SR 4233 (Tirapazamine) and by nicotinamide with carbogen Dorie, Mary J.; Menke, Douglas; Brown, J. Martin International Journal of Radiation OncologyBiologyPhysics, Vol. 28, Issue 1 https://doi.org/10.1016/0360-3016(94)90152-X	journal	January 1994
Characterization of Functional Heme Domains from Soluble Guanylate Cyclase ^† Karow, David S.; Pan, Duohai; Davis, Joseph H. Biochemistry, Vol. 44, Issue 49 https://doi.org/10.1021/bi051601b	journal	December 2005
Influence of PEG-conjugated Hemoglobin on Tumor Oxygenation and Response to Chemotherapy Yu, Minghua; Han, Jianqun; Dai, Min Artificial Cells, Blood Substitutes, and Biotechnology, Vol. 36, Issue 6 https://doi.org/10.1080/10731190802556674	journal	January 2008
Localization of the Heme Binding Region in Soluble Guanylate Cyclase ^† Zhao, Yunde; Marletta, Michael A. Biochemistry, Vol. 36, Issue 50 https://doi.org/10.1021/bi971825x	journal	December 1997
Hemoglobin and free radicals: implications for the development of a safe blood substitute Alayash, Abdu I.; Cashon, Robert E. Molecular Medicine Today, Vol. 1, Issue 3 https://doi.org/10.1016/S1357-4310(95)80089-1	journal	June 1995
Dissection of Central Carbon Metabolism of Hemoglobin-Expressing Escherichia coli by 13C Nuclear Magnetic Resonance Flux Distribution Analysis in Microaerobic Bioprocesses Frey, A. D.; Fiaux, J.; Szyperski, T. Applied and Environmental Microbiology, Vol. 67, Issue 2 https://doi.org/10.1128/AEM.67.2.680-687.2001	journal	February 2001
Isolated and purified human soluble guanylyl cyclase α1/β1 (hsgcα1/β1) Schmidt, Harald; Zabel, Ulrike; Poller, Wolfgang Ch. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6849438 US Patent Document 6,849,438	patent	February 2005
Potentiation of the Cytotoxicity of the Anticancer Agent Tirapazamine by Benzotriazine N -oxides: The Role of Redox Equilibria Anderson, Robert F.; Shinde, Sujata S.; Hay, Michael P. Journal of the American Chemical Society, Vol. 128, Issue 1 https://doi.org/10.1021/ja0559101	journal	January 2006
Ligand discrimination in soluble guanylate cyclase and the H-NOX family of heme sensor proteins Boon, Elizabeth M.; Marletta, Michael A. Current Opinion in Chemical Biology, Vol. 9, Issue 5 https://doi.org/10.1016/j.cbpa.2005.08.015	journal	October 2005
Determinants of Ligand Affinity and Heme Reactivity in H-NOX Domains Weinert, Emily E.; Plate, Lars; Whited, Charlotte A. Angewandte Chemie International Edition, Vol. 49, Issue 4 https://doi.org/10.1002/anie.200904799	journal	December 2009
Arterial Blood Pressure Responses to Cell-free Hemoglobin Solutions and the Reaction with Nitric Oxide Rohlfs, Ronald J.; Bruner, Eric; Chiu, Albert Journal of Biological Chemistry, Vol. 273, Issue 20 https://doi.org/10.1074/jbc.273.20.12128	journal	May 1998
ESPript: analysis of multiple sequence alignments in PostScript Gouet, P.; Courcelle, E.; Stuart, D. Bioinformatics, Vol. 15, Issue 4 https://doi.org/10.1093/bioinformatics/15.4.305	journal	April 1999
Method for production of stroma-free hemoglobin Winslow, Robert M.; Vandegriff, Kim D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6773613 US Patent Document 6,773,613	patent	August 2004
Clinical studies of hypoxia modification in radiotherapy Kaanders, Johannes H. A. M.; Bussink, Johan; van der Kogel, Albert J. Seminars in Radiation Oncology, Vol. 14, Issue 3 https://doi.org/10.1016/j.semradonc.2004.04.002	journal	July 2004
Femtomolar Sensitivity of a NO Sensor from Clostridium botulinum Nioche, P. Science, Vol. 306, Issue 5701 https://doi.org/10.1126/science.1103596	journal	November 2004
Compositions and methods for the delivery of nitric oxide Cary, Stephen P. L.; Boon, Elizabeth M.; Winger, Jonathan A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9493527 US Patent Document 9,493,527	patent	November 2016
Compositions and methods for the delivery of oxygen Cary, Stephen P. L.; Boon, Elizabeth M.; Weinert, Emily https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9493526 US Patent Document 9,493,526	patent	November 2016
Indications for chemotherapy in stage IV non-small cell lung cancer Gatzemeier, Ulrich Lung Cancer, Vol. 33 https://doi.org/10.1016/S0169-5002(01)00310-5	journal	October 2001
Current status of blood substitute research: towards a new paradigm Winslow, R. M. Journal of Internal Medicine, Vol. 253, Issue 5 https://doi.org/10.1046/j.1365-2796.2003.01150.x	journal	May 2003
A recombinant polymeric hemoglobin with conformational, functional, and physiological characteristics of an in vivo O ₂ transporter Bobofchak, Kevin M.; Mito, Toshiaki; Texel, Sarah J. American Journal of Physiology-Heart and Circulatory Physiology, Vol. 285, Issue 2 https://doi.org/10.1152/ajpheart.00037.2003	journal	August 2003
Methods for oxygen transport comprising a high oxygen affinity modified hemoglobin Winslow, Robert M.; Vandegriff, Kim D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6844317 US Patent Document 6,844,317	patent	January 2005
Colloid osmotic properties of modified hemoglobins: chemically cross-linked versus polyethylene glycol surface-conjugated Vandegriff, Kim D.; McCarthy, Michael; Rohlfs, Ronald J. Biophysical Chemistry, Vol. 69, Issue 1 https://doi.org/10.1016/S0301-4622(97)00079-3	journal	November 1997
Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin Winslow, Robert M.; Vandegriff, Kim D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6974795 US Patent Document 6,974,795	patent	December 2005
Nitric Oxide Binding to Prokaryotic Homologs of the Soluble Guanylate Cyclase β1 H-NOX Domain Boon, Elizabeth M.; Davis, Joseph H.; Tran, Rosalie Journal of Biological Chemistry, Vol. 281, Issue 31 https://doi.org/10.1074/jbc.M600557200	journal	May 2006
Nitric oxide signaling: no longer simply on or off Cary, Stephen P. L.; Winger, Jonathan A.; Derbyshire, Emily R. Trends in Biochemical Sciences, Vol. 31, Issue 4 https://doi.org/10.1016/j.tibs.2006.02.003	journal	April 2006
Spectroscopic Characterization of the Soluble Guanylate Cyclase-like Heme Domains from Vibrio cholerae and Thermoanaerobacter tengcongensis ^† Karow, David S.; Pan, Duohai; Tran, Rosalie Biochemistry, Vol. 43, Issue 31 https://doi.org/10.1021/bi049374l	journal	August 2004
Truncated hemoglobin HbN protects Mycobacterium bovis from nitric oxide Ouellet, H.; Ouellet, Y.; Richard, C. Proceedings of the National Academy of Sciences, Vol. 99, Issue 9 https://doi.org/10.1073/pnas.092017799	journal	April 2002
Targeted O ₂ delivery by low-P ₅₀ hemoglobin: a new basis for O ₂ therapeutics Tsai, Amy G.; Vandegriff, Kim D.; Intaglietta, Marcos American Journal of Physiology-Heart and Circulatory Physiology, Vol. 285, Issue 4 https://doi.org/10.1152/ajpheart.00307.2003	journal	October 2003
No scavenging and the hypertensive effect of hemoglobin-based blood substitutes Olson, John S.; Foley, Erin W.; Rogge, Corina Free Radical Biology and Medicine, Vol. 36, Issue 6 https://doi.org/10.1016/j.freeradbiomed.2003.11.030	journal	March 2004
Use of a Blood Substitute to Determine Instantaneous Murine Right Ventricular Thickening With Optical Coherence Tomography Villard, Joseph W.; Feldman, Marc D.; Kim, Jeehyun Circulation, Vol. 105, Issue 15 https://doi.org/10.1161/01.CIR.0000014418.99708.86	journal	April 2002
The PAS fold: A redefinition of the PAS domain based upon structural prediction Hefti, Marco H.; Françoijs, Kees-Jan; de Vries, Sacco C. European Journal of Biochemistry, Vol. 271, Issue 6 https://doi.org/10.1111/j.1432-1033.2004.04023.x	journal	March 2004
Ligand Selectivity of Soluble Guanylyl Cyclase: EFFECT OF THE HYDROGEN-BONDING TYROSINE IN THE DISTAL HEME POCKET ON BINDING OF OXYGEN, NITRIC OXIDE, AND CARBON MONOXIDE Martin, Emil; Berka, Vladimir; Bogatenkova, Elena Journal of Biological Chemistry, Vol. 281, Issue 38 https://doi.org/10.1074/jbc.M601078200	journal	July 2006
Anemia, tumor hypoxemia, and the cancer patient Varlotto, John; Stevenson, Mary Ann International Journal of Radiation OncologyBiologyPhysics, Vol. 63, Issue 1 https://doi.org/10.1016/j.ijrobp.2005.04.049	journal	September 2005
Allosteric modifiers of hemoglobin useful for decreasing oxygen affinity and preserving oxygen carrying capability of stored blood Abraham, Donald J.; Joshi, Gajanan S.; Randad, Ramnarayan https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5731454 US Patent Document 5,731,454	patent	March 1998
Oxygen Therapeutics: Oxygen Delivery Without Blood Stollings, Joanna L.; Oyen, Lance J. Pharmacotherapy, Vol. 26, Issue 10 https://doi.org/10.1592/phco.26.10.1453	journal	October 2006
Species differences in the localization of soluble guanylyl cyclase subunits in monkey and rat brain Pifarré, P.; García, A.; Mengod, G. The Journal of Comparative Neurology, Vol. 500, Issue 5 https://doi.org/10.1002/cne.21241	journal	January 2006
Kinetics of NO and O2 binding to a maleimide poly(ethylene glycol)-conjugated human haemoglobin Vandegriff, Kim D.; Bellelli, Andrea; Samaja, Michele Biochemical Journal, Vol. 382, Issue 1 https://doi.org/10.1042/BJ20040156	journal	August 2004
Binding of Oxygen and Carbon Monoxide to a Heme-regulated Phosphodiesterase from Escherichia coli: KINETICS AND INFRARED SPECTRA OF THE FULL-LENGTH WILD-TYPE ENZYME, ISOLATED PAS DOMAIN, AND MET-95 MUTANTS Taguchi, Sue; Matsui, Toshitaka; Igarashi, Jotaro Journal of Biological Chemistry, Vol. 279, Issue 5 https://doi.org/10.1074/jbc.M301013200	journal	November 2003

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