Production of biofuels and chemicals from xylose using native and engineered yeast strains

Kwak, Suryang; Jo, Jung Hyun; Yun, Eun Ju; Jin, Yong-Su; Seo, Jin-Ho

doi:10.1016/j.biotechadv.2018.12.003

Title: Production of biofuels and chemicals from xylose using native and engineered yeast strains

Journal Article · Fri Mar 01 00:00:00 EST 2019 · Biotechnology Advances

DOI:https://doi.org/10.1016/j.biotechadv.2018.12.003· OSTI ID:1495021

Kwak, Suryang ^[1]; Jo, Jung Hyun ^[2]; Yun, Eun Ju ^[3]; Jin, Yong-Su ^[1];

^[2]

Univ. of Illinois, Urbana-Champaign, IL (United States). Carl R. Woese Inst. for Genomic Biology
Seoul National Univ. (Korea, Republic of). Dept. of Agricultural Biotechnology and Center for Food and Bioconvergence
Univ. of Illinois, Urbana-Champaign, IL (United States). Carl R. Woese Inst. for Genomic Biology; Korea Univ., Seoul (South Korea). Dept. of Biotechnology, Graduate School

Numerous metabolic engineering strategies have allowed yeasts to efficiently assimilate xylose, the second most abundant sugar component of lignocellulosic biomass. During the investigation of xylose utilization by yeasts, a global rewiring of metabolic networks upon xylose cultivation has been captured, as opposed to a pattern of glucose repression. A clear understanding of the xylose-induced metabolic reprogramming in yeast would shed light on the optimization of yeast-based bioprocesses to produce biofuels and chemicals using xylose. In this review, we delved into characteristics of yeast xylose metabolism, and potential benefits of using xylose as a carbon source to produce various biochemicals with examples. Transcriptomic and metabolomic patterns of xylose-grown yeast cells were distinct from those on glucose—a conventional sugar of industrial biotechnology—and the gap might lead to opportunities to produce biochemicals efficiently. Indeed, limited glycolytic metabolic fluxes during xylose utilization could result in enhanced production of metabolites whose biosynthetic pathways compete for precursors with ethanol fermentation. Also, alleviation of glucose repression on cytosolic acetyl coenzyme A (acetyl-CoA) synthesis, and respiratory energy metabolism during xylose utilization enhanced production of acetyl-CoA derivatives. Consideration of singular properties of xylose metabolism, such as redox cofactor imbalance between xylose reductase and xylitol dehydrogenase, is necessary to maximize these positive xylose effects. As a result, this review argues the importance and benefits of xylose utilization as not only a way of expanding a substrate range, but also an effective environmental perturbation for the efficient production of advanced biofuels and chemicals in yeasts.

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Research Organization:: Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); Korea Institute for Industrial Economics and Trade (KIET)

Grant/Contract Number:: SC0018420

OSTI ID:: 1495021

Alternate ID(s):: OSTI ID: 1487444

Journal Information:: Biotechnology Advances, Vol. 37, Issue 2; ISSN 0734-9750

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 66 works

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Rewired cellular signaling coordinates sugar and hypoxic responses for anaerobic xylose fermentation in yeast Myers, Kevin S.; Riley, Nicholas M.; MacGilvray, Matthew E. PLOS Genetics, Vol. 15, Issue 3 https://doi.org/10.1371/journal.pgen.1008037	journal	March 2019
A Thi2p Regulatory Network Controls the Post-glucose Effect of Xylose Utilization in Saccharomyces cerevisiae Wei, Shan; Bai, Penggang; Liu, Yanan Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.01649	journal	July 2019

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