Sex-Dependent Effects of the Histone Deacetylase Inhibitor, Sodium Valproate, on Reversal Learning After Developmental Arsenic Exposure

Tyler, Christina R. Steadman; Smoake, Jane J. W.; Solomon, Elizabeth R.; Villicana, Estrella; Caldwell, Kevin K.; Allan, Andrea M.

doi:10.3389/fgene.2018.00200

Title: Sex-Dependent Effects of the Histone Deacetylase Inhibitor, Sodium Valproate, on Reversal Learning After Developmental Arsenic Exposure

Journal Article · Fri Jun 15 00:00:00 EDT 2018 · Frontiers in Genetics

DOI:https://doi.org/10.3389/fgene.2018.00200· OSTI ID:1481146

^[1]; Smoake, Jane J. W. ^[2]; Solomon, Elizabeth R. ^[2]; Villicana, Estrella ^[2]; Caldwell, Kevin K. ^[2]; Allan, Andrea M. ^[2]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Univ. of New Mexico Health Sciences Center, Albuquerque, NM (United States)

Here, several studies have demonstrated that exposure to arsenic in drinking water adversely affects brain development and cognitive function in adulthood. While the mechanism by which arsenic induces adverse neurological outcomes remains elusive, studies suggest a link between reduced levels of histone acetylation and impaired performance on a variety of behavioral tasks following arsenic exposure.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1481146

Report Number(s):: LA-UR-18-20125

Journal Information:: Frontiers in Genetics, Vol. 9; ISSN 1664-8021

Publisher:: FrontiersCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 10 works

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