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Title: Applying Optimization Algorithms to Tuberculosis Antibiotic Treatment Regimens

Journal Article · · Cellular and Molecular Bioengineering
 [1];  [2];  [2];  [1]
  1. Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Chemical Engineering
  2. Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Chemical Engineering and Dept. of Microbiology and Immunology
+ Show Author Affiliations

Tuberculosis (TB), one of the most common infectious diseases, requires treatment with multiple antibiotics taken over at least 6 months. This long treatment often results in poor patient-adherence, which can lead to the emergence of multi-drug resistant TB. New antibiotic treatment strategies are sorely needed. New antibiotics are being developed or repurposed to treat TB, but as there are numerous potential antibiotics, dosing sizes and potential schedules, the regimen design space for new treatments is too large to search exhaustively. Furthermore we propose a method that combines an agent-based multi-scale model capturing TB granuloma formation with algorithms for mathematical optimization to identify optimal TB treatment regimens.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)
Sponsoring Organization:
USDOE Office of Science (SC), Advanced Scientific Computing Research (ASCR)
Grant/Contract Number:
AC02-05CH11231
OSTI ID:
1461962
Journal Information:
Cellular and Molecular Bioengineering, Vol. 10, Issue 6; ISSN 1865-5025
Publisher:
SpringerCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 16 works
Citation information provided by
Web of Science

References (46)

A methodology for performing global uncertainty and sensitivity analysis in systems biology journal September 2008
Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity: Agent-based modeling
  • Hunt, C. Anthony; Kennedy, Ryan C.; Kim, Sean H. J.
  • Wiley Interdisciplinary Reviews: Systems Biology and Medicine, Vol. 5, Issue 4 https://doi.org/10.1002/wsbm.1222
journal June 2013
Agent‐based models in translational systems biology
  • An, Gary; Mi, Qi; Dutta‐Moscato, Joyeeta
  • Wiley Interdisciplinary Reviews: Systems Biology and Medicine, Vol. 1, Issue 2 https://doi.org/10.1002/wsbm.45
journal September 2009
Multiscale Computational Modeling Reveals a Critical Role for TNF-α Receptor 1 Dynamics in Tuberculosis Granuloma Formation journal February 2011
Does directly observed therapy improve tuberculosis treatment? More evidence is needed to guide tuberculosis policy journal October 2016
Engineering design applications of surrogate-assisted optimization techniques journal September 2012
A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment journal February 2015
Pharmacokinetic Evaluation of the Penetration of Antituberculosis Agents in Rabbit Pulmonary Lesions journal October 2011
In silico evaluation and exploration of antibiotic tuberculosis treatment regimens journal November 2015
Treatment of tuberculosis and optimal dosing schedules journal December 2010
Optimization and Control of Agent-Based Models in Biology: A Perspective journal November 2016
Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques journal July 2012
Solving a multi-floor layout design model of a dynamic cellular manufacturing system by an efficient genetic algorithm journal January 2014
Multi-Scale Modeling Predicts a Balance of Tumor Necrosis Factor-α and Interleukin-10 Controls the Granuloma Environment during Mycobacterium tuberculosis Infection journal July 2013
A review on type-2 fuzzy logic applications in clustering, classification and pattern recognition journal August 2014
Optimal control of the chemotherapy of HIV journal August 1997
A Taxonomy of Global Optimization Methods Based on Response Surfaces journal December 2001
Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research journal July 2007
Multifidelity Surrogate Modeling of Experimental and Computational Aerodynamic Data Sets journal February 2011
Integrated PK-PD and agent-based modeling in oncology journal January 2015
Integrated Analysis of Computer and Physical Experiments journal May 2004
High-Sensitivity MALDI-MRM-MS Imaging of Moxifloxacin Distribution in Tuberculosis-Infected Rabbit Lungs and Granulomatous Lesions journal March 2011
Multi-fidelity optimization via surrogate modelling
  • Forrester, Alexander I. J.; Sóbester, András; Keane, Andy J.
  • Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 463, Issue 2088 https://doi.org/10.1098/rspa.2007.1900
journal September 2007
Optimizing the clinical pharmacology of tuberculosis medications journal July 2015
Genetic algorithms: concepts and applications [in engineering design] journal January 1996
Patients' Costs and Cost-Effectiveness of Tuberculosis Treatment in DOTS and Non-DOTS Facilities in Rio de Janeiro, Brazil journal November 2010
Computational systems biology approaches to anti-angiogenic cancer therapeutics journal February 2015
Parallel metaheuristics: recent advances and new trends journal August 2012
Surrogate-assisted evolutionary computation: Recent advances and future challenges journal June 2011
Examining the Relationship between Pre-Malignant Breast Lesions, Carcinogenesis and Tumor Evolution in the Mammary Epithelium Using an Agent-Based Model journal March 2016
Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time journal January 2017
In silico Modeling and In vivo Efficacy of Cancer-Preventive Vaccinations journal October 2010
Efficient Global Optimization of Expensive Black-Box Functions journal January 1998
Four-Month Moxifloxacin-Based Regimens for Drug-Sensitive Tuberculosis journal October 2014
Multi objective optimization of computationally expensive multi-modal functions with RBF surrogates and multi-rule selection journal February 2015
Multiscale Computational Models of Complex Biological Systems journal July 2013
Computational Modeling of Muscle Regeneration and Adaptation to Advance Muscle Tissue Regeneration Strategies journal January 2016
A multi-scale approach to designing therapeutics for tuberculosis journal April 2015
Advances in the development of new tuberculosis drugs and treatment regimens journal April 2013
Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model journal March 2016
Strategies for Efficient Numerical Implementation of Hybrid Multi-scale Agent-Based Models to Describe Biological Systems journal November 2014
Agent-Based Modeling in Systems Pharmacology: Agent-Based Modeling in Systems Pharmacology journal November 2015
Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium journal January 2009
The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling journal October 2016
Intermittent treatment interruption and its effect on multidrug resistant tuberculosis treatment outcome in Ethiopia journal December 2019
Origin of tuberculosis in the Paleolithic predicts unprecedented population growth and female resistance journal January 2020

Cited By (3)

Agent‐based models of inflammation in translational systems biology: A decade later journal June 2019
Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas journal May 2018
Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas journal March 2020

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59 BASIC BIOLOGICAL SCIENCES
Tuberculosis
Antibiotics
Agent-based modeling
Genetic algorithm
Surrogate-assisted optimization