Systems and methods for integrating ion mobility and ion trap mass spectrometers

Ibrahim, Yehia M.; Garimella, Sandilya; Prost, Spencer A.

Title: Systems and methods for integrating ion mobility and ion trap mass spectrometers

Patent · Tue Apr 10 00:00:00 EDT 2018

OSTI ID:1434509

Ibrahim, Yehia M.; Garimella, Sandilya; Prost, Spencer A.

Described herein are examples of systems and methods for integrating IMS and MS systems. In certain examples, systems and methods for decoding double multiplexed data are described. The systems and methods can also perform multiple refining procedures in order to minimize the demultiplexing artifacts. The systems and methods can be used, for example, for the analysis of proteomic and petroleum samples, where the integration of IMS and high mass resolution are used for accurate assignment of molecular formulae.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

Assignee:: Battelle Memorial Institute (Richland, WA)

Patent Number(s):: 9,939,409

Application Number:: 15/227,743

OSTI ID:: 1434509

Resource Relation:: Patent File Date: 2016 Aug 03

Country of Publication:: United States

Language:: English

References (7)

Mass analysis of mobility selected ion populations Clowers, Brian H.; Hill, Jr., Herbert H.; Dwivedi, Prabha https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7560688 US Patent Document 7,560,688	patent	July 2009
Method and apparatus for coupling fast separations and slow detection systems Belov, Mikhail E. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9269548 US Patent Document 9,269,548	patent	February 2016
Method and Apparatus for Coupling Fast Separation and Slow Detection Systems Belov, Mikhail E. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120261564 US Patent Application 13/086244; 20120261564	patent-application	October 2012
Data Acquisition Modes for Ion Mobility Time-of-Flight Mass Spectrometry Ugarov, Michael https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130161506 US Patent Application 13/335059; 20130161506	patent-application	June 2013
Methods of Resolving Artifacts in Hadamard-Transformed Data Crowell, Kevin; Prost, Spencer A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140025314 US Patent Application 13/866686; 20140025314	patent-application	January 2014
Data Processing for Multiplexed Spectrometry Wang, JR., Jun https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20150364305 US Patent Application 14/686569; 20150364305	patent-application	December 2015
Multiplexed Ion Mobility Spectrometry-Orthogonal Time-of-Flight Mass Spectrometry Belov, Mikhail E.; Buschbach, Michael A.; Prior, David C. Analytical Chemistry, Vol. 79, Issue 6, p. 2451-2462 https://doi.org/10.1021/ac0617316	journal	March 2007

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