Laser Ablation-Aerosol Mass Spectrometry-Chemical Ionization Mass Spectrometry for Ambient Surface Imaging

Berry, Jennifer L.; Day, Douglas A.; Elseberg, Tim; Palm, Brett B.; Hu, Weiwei; Abdelhamid, Aroob; Schroder, Jason C.; Karst, Uwe; Jimenez, Jose L.; Browne, Eleanor C.

doi:10.1021/acs.analchem.7b05255

Title: Laser Ablation-Aerosol Mass Spectrometry-Chemical Ionization Mass Spectrometry for Ambient Surface Imaging

Journal Article · Tue Feb 20 00:00:00 EST 2018 · Analytical Chemistry

DOI:https://doi.org/10.1021/acs.analchem.7b05255· OSTI ID:1427500

Berry, Jennifer L. ^[1]; Day, Douglas A. ^[1]; Elseberg, Tim ^[2]; Palm, Brett B. ^[1]; Hu, Weiwei ^[1]; Abdelhamid, Aroob ^[1]; Schroder, Jason C. ^[1];

^[3];

^[1];

^[1]

Univ. of Colorado, Boulder, CO (United States). Dept. of Chemistry and Biochemistry. Cooperative Inst. for Research in Environmental Sciences
Univ. of Munster (Germany). Inst. of Inorganic and Analytical Chemistry
Univ. of Colorado, Boulder, CO (United States). Dept. of Chemistry and Biochemistry. Cooperative Inst. for Research in Environmental Sciences; Univ. of Munster (Germany). Inst. of Inorganic and Analytical Chemistry

Mass spectrometry imaging is becoming an increasingly common analytical technique due to its ability to provide spatially resolved chemical information. In this paper, we report a novel imaging approach combining laser ablation with two mass spectrometric techniques, aerosol mass spectrometry and chemical ionization mass spectrometry, separately and in parallel. Both mass spectrometric methods provide the fast response, rapid data acquisition, low detection limits, and high-resolution peak separation desirable for imaging complex samples. Additionally, the two techniques provide complementary information with aerosol mass spectrometry providing near universal detection of all aerosol molecules and chemical ionization mass spectrometry with a heated inlet providing molecular-level detail of both gases and aerosols. The two techniques operate with atmospheric pressure interfaces and require no matrix addition for ionization, allowing for samples to be investigated in their native state under ambient pressure conditions. We demonstrate the ability of laser ablation-aerosol mass spectrometry-chemical ionization mass spectrometry (LA-AMS-CIMS) to create 2D images of both standard compounds and complex mixtures. Finally, the results suggest that LA-AMS-CIMS, particularly when combined with advanced data analysis methods, could have broad applications in mass spectrometry imaging applications.

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Research Organization:: Univ. of Colorado, Boulder, CO (United States); Univ. of Munster (Germany)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); Univ. of Colorado (United States); USEPA; German Research Foundation (DFG)

Grant/Contract Number:: SC0016559; FP-91761701-0

OSTI ID:: 1427500

Journal Information:: Analytical Chemistry, Vol. 90, Issue 6; ISSN 0003-2700

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 5 works

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