Localized Unresectable Pancreatic Cancer Treated with High Energy Neutrons and Chemotherapy at Fermilab - Preliminary Results

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Int.J.Radiat.Oncol.Biol.Phys.

DOI:https://doi.org/10.1016/0360-3016(90)90849-F· OSTI ID:1418793

Saroja, K. R. ^[1]; Cohen, Lionel ^[1]; Hendrickson, Frank R. ^[1]; Mansell, JoAnne ^[2]

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1. Unlisted, US, IL
2. Fermilab

Between January 1985 and July 1989 a total of thirty-eight patients with locally advanced pancreatic cancer were treated with high energy neutrons at Fermilab. Twenty-one patients received only neutrons and seventeen were given chemotherapy in addition, either concurrently or subsequently following the completion of neutron irradiation. This is a retrospective study. Data were analyzed for tolerance, complications and survival. Three of the twenty-one (14%) patients who received only neutron beam therapy developed Grade ID or greater complications in the RTOG/EORTC scale. The median survival was 6.4 months. One of these patients is alive 10 months post treatment. Of seventeen patients who also received chemotherapy, five (29%) had severe complications. However, median survival was 13.5 months. Four of these seventeen patients are still alive at the time of this analysis. The preliminary results show that there is improvement in the survival of patients treated with combined neutron irradiation and chemotherapy. A pilot study to further evaluate these results in a larger group of patients is underway. Details of complications and chemotherapy regimen will be preseqted.

• Research Organization: Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)
• Sponsoring Organization: USDOE Office of Science (SC), High Energy Physics (HEP)
• DOE Contract Number: AC02-07CH11359
• OSTI ID: 1418793
• Report Number(s): FERMILAB-PUB-90-359-AD; 1651149
• Journal Information: Int.J.Radiat.Oncol.Biol.Phys., Vol. 19, Issue Suppl 1
• Country of Publication: United States
• Language: English