Adsorption and Recovery of Polyphenolic Flavonoids Using TiO2-Functionalized Mesoporous Silica Nanoparticles

Khan, M. Arif; Wallace, William T.; Islam, Syed Z.; Nagpure, Suraj; Strzalka, Joseph; Littleton, John M.; Rankin, Stephen E.; Knutson, Barbara L.

doi:10.1021/acsami.7b09510

Title: Adsorption and Recovery of Polyphenolic Flavonoids Using TiO₂-Functionalized Mesoporous Silica Nanoparticles

Journal Article · Mon Aug 21 00:00:00 EDT 2017 · ACS Applied Materials and Interfaces

DOI:https://doi.org/10.1021/acsami.7b09510· OSTI ID:1395148

Khan, M. Arif ^[1]; Wallace, William T. ^[1]; Islam, Syed Z. ^[1]; Nagpure, Suraj ^[1]; Strzalka, Joseph ^[2]; Littleton, John M. ^[3];

^[1];

^[1]

Univ. of Kentucky, Lexington, KY (United States)
Argonne National Lab. (ANL), Argonne, IL (United States)
Naprogenix Inc., Lexington, KY (United States)

Exploiting specific interactions with titania (TiO₂) has been proposed for the separation and recovery of a broad range of biomolecules and natural products, including therapeutic polyphenolic flavonoids which are susceptible to degradation, such as quercetin. Functionalizing mesoporous silica with TiO₂ has many potential advantages over bulk and mesoporous TiO₂ as an adsorbent for natural products, including robust synthetic approaches leading to high surface area, stable separation platforms. Here, TiO₂ surface functionalized mesoporous silica nanoparticles (MSNPs) are synthesized and characterized as a function of TiO₂ content (up to 636 mg TiO2/g). The adsorption isotherms of two polyphenolic flavonoids, quercetin and rutin, were determined (0.05-10 mg/ml in ethanol), and a 100-fold increase in the adsorption capacity was observed relative to functionalized nonporous particles with similar TiO₂ surface coverage. An optimum extent of functionalization (approximately 440 mg TiO₂/g particles) is interpreted from characterization techniques including grazing incidence x-ray scattering (GIXS), high resolution transmission electron microscopy (HRTEM) and nitrogen adsorption, which examined the interplay between the extent of TiO₂ functionalization and the accessibility of the porous structures. The recovery of flavonoids is demonstrated using ligand displacement in ethanolic citric acid solution (20% w/v), in which greater than 90% recovery can be achieved in a multistep extraction process. The radical scavenging activity (RSA) of the recovered and particle-bound quercetin as measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay demonstrates greater than 80% retention of antioxidant activity by both particle-bound and recovered quercetin. In conclusion, these mesoporous titanosilicate materials can serve as a synthetic platform to isolate, recover, and potentially deliver degradation-sensitive natural products to biological systems.

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22), Scientific User Facilities Division

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1395148

Journal Information:: ACS Applied Materials and Interfaces, Vol. 9, Issue 37; ISSN 1944-8244

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 51 works

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Title: Adsorption and Recovery of Polyphenolic Flavonoids Using TiO₂-Functionalized Mesoporous Silica Nanoparticles