Genomic Evolution of Breast Cancer Metastasis and Relapse

Yates, Lucy R.; Knappskog, Stian; Wedge, David; Farmery, James H. R.; Gonzalez, Santiago; Martincorena, Inigo; Alexandrov, Ludmil B.; Van Loo, Peter; Haugland, Hans Kristian; Lilleng, Peer Kaare; Gundem, Gunes; Gerstung, Moritz; Pappaemmanuil, Elli; Gazinska, Patrycja; Bhosle, Shriram G.; Jones, David; Raine, Keiran; Mudie, Laura; Latimer, Calli; Sawyer, Elinor; Desmedt, Christine; Sotiriou, Christos; Stratton, Michael R.; Sieuwerts, Anieta M.; Lynch, Andy G.; Martens, John W.; Richardson, Andrea L.; Tutt, Andrew; Lønning, Per Eystein; Campbell, Peter J.

doi:10.1016/j.ccell.2017.07.005

Title: Genomic Evolution of Breast Cancer Metastasis and Relapse

Journal Article · Mon Aug 14 00:00:00 EDT 2017 · Cancer Cell

DOI:https://doi.org/10.1016/j.ccell.2017.07.005· OSTI ID:1392804

Yates, Lucy R. ^[1]; Knappskog, Stian ^[2]; Wedge, David ^[3]; Farmery, James H. R. ^[4]; Gonzalez, Santiago ^[5]; Martincorena, Inigo ^[6]; Alexandrov, Ludmil B. ^[7]; Van Loo, Peter ^[8]; Haugland, Hans Kristian ^[9]; Lilleng, Peer Kaare ^[9]; Gundem, Gunes ^[10]; Gerstung, Moritz ^[5]; Pappaemmanuil, Elli ^[10]; Gazinska, Patrycja ^[11]; Bhosle, Shriram G. ^[6]; Jones, David ^[6]; Raine, Keiran ^[6]; Mudie, Laura ^[6]; Latimer, Calli ^[6]; Sawyer, Elinor ^[12] more »

Wellcome Trust Sanger Inst., Hinxton (United Kingdom); English National Health Service (NHS), London (United Kingdom). Guys and St Thomas' NHS Trust, Dept. of Clinical Oncology
Univ. of Bergen (Norway). Section of Oncology, Dept. of Clinical Science; Haukeland University Hospital, Bergen (Norway). Dept. of Clinical Science
Wellcome Trust Sanger Inst., Hinxton (United Kingdom); Univ. of Oxford (United Kingdom). Big Data Inst.
Univ. of Cambridge (United Kingdom). Cancer Research UK Cambridge Inst.
Wellcome Trust Sanger Inst., Hinxton (United Kingdom); European Bioinformatics Inst. EMBL-EBI, Hinxton (United Kingdom)
Wellcome Trust Sanger Inst., Hinxton (United Kingdom)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of New Mexico Comprehensive Cancer Center, Albuquerque, NM (United States)
Francis Crick Inst., London (United Kingdom); Univ. of Leuven (Belgium)
Haukeland Univ. Hospital, Bergen (Norway). Dept. of Pathology; Univ. of Bergen, Bergen (Norway). Gade Lab. for Pathology, Dept. of Clinical Medicine
Wellcome Trust Sanger Inst., Hinxton (United Kingdom); Memorial Sloan Kettering Cancer Inst., New York, NY (United States). Computational Oncology, Epidemiology and Biostatistics
King's College London (United Kingdom). Division of Cancer Studies
English National Health Service (NHS), London (United Kingdom). Guys and St Thomas' NHS Trust, Dept. of Clinical Oncology; King's College London (United Kingdom). Division of Cancer Studies
Univ. Libre de Bruxelles, Brussels (Belgium). Breast Cancer Translational Research Lab.
Erasmus Univ. Medical Center, Rotterdam (Netherlands). Erasmus MC Cancer Inst. and Cancer Genomics Netherlands
Erasmus Univ. Medical Center, Rotterdam (Netherlands). Erasmus MC Cancer Inst. and Cancer Genomics Netherlands
Brigham and Women's Hospital (Harvard Medical School), Boston, MA (United States). Dept. of Pathology; Dana-Farber Cancer Inst., Boston, MA (United States)
King's College Lo Division of Cancer Studies; King's College London (United Kingdom). Breast Cancer Now Research Unit; Inst. of Cancer Research, London (United Kingdom). Breast Cancer Now Toby Robins Research Centre

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel of 365 genes on 299 samples from 170 patients with locally relapsed or metastatic breast cancer. Several lines of analysis indicate that clones seeding metastasis or relapse disseminate late from primary tumors, but continue to acquire mutations, mostly accessing the same mutational processes active in the primary tumor. Most distant metastases acquired driver mutations not seen in the primary tumor, drawing from a wider repertoire of cancer genes than early drivers. Lastly, these include a number of clinically actionable alterations and mutations inactivating SWI-SNF and JAK2-STAT3 pathways.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE National Nuclear Security Administration (NNSA); Wellcome Trust; Bergen Research Foundation; Norwegian Cancer Society; Norwegian Research Council

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1392804

Report Number(s):: LA-UR-16-27672

Journal Information:: Cancer Cell, Vol. 32, Issue 2; ISSN 1535-6108

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 388 works

Citation information provided by
Web of Science

References (59)

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients Aas, Turid; Børresen, Anne-Lise; Geisler, Stephanie Nature Medicine, Vol. 2, Issue 7 https://doi.org/10.1038/nm0796-811	journal	July 1996
Signatures of mutational processes in human cancer Alexandrov, Ludmil B.; Nik-Zainal, Serena; Wedge, David C. Nature, Vol. 500, Issue 7463 https://doi.org/10.1038/nature12477	journal	August 2013
Deciphering Signatures of Mutational Processes Operative in Human Cancer Alexandrov, Ludmil B.; Nik-Zainal, Serena; Wedge, David C. Cell Reports, Vol. 3, Issue 1 https://doi.org/10.1016/j.celrep.2012.12.008	journal	January 2013
Precision medicine for metastatic breast cancer—limitations and solutions Arnedos, Monica; Vicier, Cecile; Loi, Sherene Nature Reviews Clinical Oncology, Vol. 12, Issue 12 https://doi.org/10.1038/nrclinonc.2015.123	journal	July 2015
Molecular Profiling of the Residual Disease of Triple-Negative Breast Cancers after Neoadjuvant Chemotherapy Identifies Actionable Therapeutic Targets Balko, J. M.; Giltnane, J. M.; Wang, K. Cancer Discovery, Vol. 4, Issue 2 https://doi.org/10.1158/2159-8290.CD-13-0286	journal	December 2013
Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence Balko, Justin M.; Schwarz, Luis J.; Luo, Na Science Translational Medicine, Vol. 8, Issue 334 https://doi.org/10.1126/scitranslmed.aad3001	journal	April 2016
Sequence analysis of mutations and translocations across breast cancer subtypes Banerji, Shantanu; Cibulskis, Kristian; Rangel-Escareno, Claudia Nature, Vol. 486, Issue 7403 https://doi.org/10.1038/nature11154	journal	June 2012
Mutational signatures of ionizing radiation in second malignancies Behjati, Sam; Gundem, Gunes; Wedge, David C. Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms12605	journal	September 2016
p53 protein accumulation predicts poor response to tamoxifen therapy of patients with recurrent breast cancer. Berns, E. M.; Klijn, J. G.; van Putten, W. L. Journal of Clinical Oncology, Vol. 16, Issue 1 https://doi.org/10.1200/JCO.1998.16.1.121	journal	January 1998
The landscape of somatic copy-number alteration across human cancers Beroukhim, Rameen; Mermel, Craig H.; Porter, Dale Nature, Vol. 463, Issue 7283 https://doi.org/10.1038/nature08822	journal	February 2010
Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations Brown, David; Smeets, Dominiek; Székely, Borbála Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/ncomms14944	journal	April 2017
Prevalence of ESR1 Mutations in Cell-Free DNA and Outcomes in Metastatic Breast Cancer: A Secondary Analysis of the BOLERO-2 Clinical Trial Chandarlapaty, Sarat; Chen, David; He, Wei JAMA Oncology, Vol. 2, Issue 10 https://doi.org/10.1001/jamaoncol.2016.1279	journal	October 2016
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer Ciriello, Giovanni; Gatza, Michael L.; Beck, Andrew H. Cell, Vol. 163, Issue 2 https://doi.org/10.1016/j.cell.2015.09.033	journal	October 2015
Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation Costello, Maura; Pugh, Trevor J.; Fennell, Timothy J. Nucleic Acids Research, Vol. 41, Issue 6 https://doi.org/10.1093/nar/gks1443	journal	January 2013
Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle De Mattos-Arruda, L.; Weigelt, B.; Cortes, J. Annals of Oncology, Vol. 25, Issue 9 https://doi.org/10.1093/annonc/mdu239	journal	September 2014
Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing Demeulemeester, Jonas; Kumar, Parveen; Møller, Elen K. Genome Biology, Vol. 17, Issue 1 https://doi.org/10.1186/s13059-016-1109-7	journal	December 2016
Genome remodelling in a basal-like breast cancer metastasis and xenograft Ding, Li; Ellis, Matthew J.; Li, Shunqiang Nature, Vol. 464, Issue 7291 https://doi.org/10.1038/nature08989	journal	April 2010
Whole-genome analysis informs breast cancer response to aromatase inhibition Ellis, Matthew J.; Ding, Li; Shen, Dong Nature, Vol. 486, Issue 7403 https://doi.org/10.1038/nature11143	journal	June 2012
A census of human cancer genes Futreal, P. Andrew; Coin, Lachlan; Marshall, Mhairi Nature Reviews Cancer, Vol. 4, Issue 3 https://doi.org/10.1038/nrc1299	journal	March 2004
Punctuated copy number evolution and clonal stasis in triple-negative breast cancer Gao, Ruli; Davis, Alexander; McDonald, Thomas O. Nature Genetics, Vol. 48, Issue 10 https://doi.org/10.1038/ng.3641	journal	August 2016
Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation Gellert, Pascal; Segal, Corrinne V.; Gao, Qiong Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms13294	journal	November 2016
The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis Gibson, William J.; Hoivik, Erling A.; Halle, Mari K. Nature Genetics, Vol. 48, Issue 8 https://doi.org/10.1038/ng.3602	journal	June 2016
Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Harris, Lyndsay N.; Ismaila, Nofisat; McShane, Lisa M. Journal of Clinical Oncology, Vol. 34, Issue 10 https://doi.org/10.1200/JCO.2015.65.2289	journal	April 2016
Decreased expression of ARID1A associates with poor prognosis and promotes metastases of hepatocellular carcinoma He, Fei; Li, Jie; Xu, JianFeng Journal of Experimental & Clinical Cancer Research, Vol. 34, Issue 1 https://doi.org/10.1186/s13046-015-0164-3	journal	May 2015
Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases Hoadley, Katherine A.; Siegel, Marni B.; Kanchi, Krishna L. PLOS Medicine, Vol. 13, Issue 12 https://doi.org/10.1371/journal.pmed.1002174	journal	December 2016
A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies Howie, Bryan N.; Donnelly, Peter; Marchini, Jonathan PLoS Genetics, Vol. 5, Issue 6 https://doi.org/10.1371/journal.pgen.1000529	journal	June 2009
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor Juric, Dejan; Castel, Pau; Griffith, Malachi Nature, Vol. 518, Issue 7538 https://doi.org/10.1038/nature13948	journal	November 2014
Mutational landscape and significance across 12 major cancer types Kandoth, Cyriac; McLellan, Michael D.; Vandin, Fabio Nature, Vol. 502, Issue 7471 https://doi.org/10.1038/nature12634	journal	October 2013
Loss of ARID1A expression is related to shorter progression-free survival and chemoresistance in ovarian clear cell carcinoma Katagiri, Atsuko; Nakayama, Kentaro; Rahman, Mohammed Tanjimur Modern Pathology, Vol. 25, Issue 2 https://doi.org/10.1038/modpathol.2011.161	journal	November 2011
Parallel progression of primary tumours and metastases Klein, Christoph A. Nature Reviews Cancer, Vol. 9, Issue 4 https://doi.org/10.1038/nrc2627	journal	April 2009
Discovery and saturation analysis of cancer genes across 21 tumour types Lawrence, Michael S.; Stojanov, Petar; Mermel, Craig H. Nature, Vol. 505, Issue 7484 https://doi.org/10.1038/nature12912	journal	January 2014
High burden and pervasive positive selection of somatic mutations in normal human skin Martincorena, I.; Roshan, A.; Gerstung, M. Science, Vol. 348, Issue 6237 https://doi.org/10.1126/science.aaa6806	journal	May 2015
Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers Miller, Christopher A.; Gindin, Yevgeniy; Lu, Charles Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms12498	journal	August 2016
Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification Ng, Charlotte KY; Martelotto, Luciano G.; Gauthier, Arnaud Genome Biology, Vol. 16, Issue 1 https://doi.org/10.1186/s13059-015-0657-6	journal	May 2015
Landscape of somatic mutations in 560 breast cancer whole-genome sequences Nik-Zainal, Serena; Davies, Helen; Staaf, Johan Nature, Vol. 534, Issue 7605 https://doi.org/10.1038/nature17676	journal	May 2016
The Life History of 21 Breast Cancers Nik-Zainal, Serena; Van Loo, Peter; Wedge, David C. Cell, Vol. 149, Issue 5 https://doi.org/10.1016/j.cell.2012.04.023	journal	May 2012
Whole–genome characterization of chemoresistant ovarian cancer Patch, Ann-Marie; Christie, Elizabeth L.; Etemadmoghadam, Dariush Nature, Vol. 521, Issue 7553 https://doi.org/10.1038/nature14410	journal	May 2015
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database Petitjean, Audrey; Mathe, Ewy; Kato, Shunsuke Human Mutation, Vol. 28, Issue 6 https://doi.org/10.1002/humu.20495	journal	June 2007
Methods and challenges in timing chromosomal abnormalities within cancer samples Purdom, Elizabeth; Ho, Christine; Grasso, Catherine S. Bioinformatics, Vol. 29, Issue 24 https://doi.org/10.1093/bioinformatics/btt546	journal	September 2013
Activating ESR1 mutations in hormone-resistant metastatic breast cancer Robinson, Dan R.; Wu, Yi-Mi; Vats, Pankaj Nature Genetics, Vol. 45, Issue 12 https://doi.org/10.1038/ng.2823	journal	November 2013
The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program “CASCADE” Savas, Peter; Teo, Zhi Ling; Lefevre, Christophe PLOS Medicine, Vol. 13, Issue 12 https://doi.org/10.1371/journal.pmed.1002204	journal	December 2016
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution Shah, Sohrab P.; Morin, Ryan D.; Khattra, Jaswinder Nature, Vol. 461, Issue 7265 https://doi.org/10.1038/nature08489	journal	October 2009
The clonal and mutational evolution spectrum of primary triple-negative breast cancers Shah, Sohrab P.; Roth, Andrew; Goya, Rodrigo Nature, Vol. 486, Issue 7403 https://doi.org/10.1038/nature10933	journal	April 2012
Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development Stephens, Philip J.; Greenman, Chris D.; Fu, Beiyuan Cell, Vol. 144, Issue 1 https://doi.org/10.1016/j.cell.2010.11.055	journal	January 2011
The landscape of cancer genes and mutational processes in breast cancer Stephens, Philip J.; Tarpey, Patrick S.; Davies, Helen Nature, Vol. 486, Issue 7403 https://doi.org/10.1038/nature11017	journal	May 2012
Survival in patients with metastatic recurrent breast cancer after adjuvant chemotherapy: Little evidence of improvement over the past 30 years Tevaarwerk, Amye J.; Gray, Robert J.; Schneider, Bryan P. Cancer, Vol. 119, Issue 6 https://doi.org/10.1002/cncr.27819	journal	October 2012
ESR1 ligand-binding domain mutations in hormone-resistant breast cancer Toy, Weiyi; Shen, Yang; Won, Helen Nature Genetics, Vol. 45, Issue 12 https://doi.org/10.1038/ng.2822	journal	November 2013
Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity Turner, Kristen M.; Deshpande, Viraj; Beyter, Doruk Nature, Vol. 543, Issue 7643 https://doi.org/10.1038/nature21356	journal	February 2017
FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer Turner, Nicholas; Pearson, Alex; Sharpe, Rachel Cancer Research, Vol. 70, Issue 5 https://doi.org/10.1158/0008-5472.CAN-09-3746	journal	February 2010
Allele-specific copy number analysis of tumors Van Loo, P.; Nordgard, S. H.; Lingjaerde, O. C. Proceedings of the National Academy of Sciences, Vol. 107, Issue 39 https://doi.org/10.1073/pnas.1009843107	journal	September 2010
Clonal evolution in breast cancer revealed by single nucleus genome sequencing Wang, Yong; Waters, Jill; Leung, Marco L. Nature, Vol. 512, Issue 7513 https://doi.org/10.1038/nature13600	journal	July 2014
Subclonal diversification of primary breast cancer revealed by multiregion sequencing Yates, Lucy R.; Gerstung, Moritz; Knappskog, Stian Nature Medicine, Vol. 21, Issue 7 https://doi.org/10.1038/nm.3886	journal	June 2015
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma Zaretsky, Jesse M.; Garcia-Diaz, Angel; Shin, Daniel S. New England Journal of Medicine, Vol. 375, Issue 9 https://doi.org/10.1056/NEJMoa1604958	journal	September 2016
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients Zehir, Ahmet; Benayed, Ryma; Shah, Ronak H. Nature Medicine, Vol. 23, Issue 6 https://doi.org/10.1038/nm.4333	journal	May 2017
ESR1Mutations in Cell-Free DNA of Breast Cancer Fuqua, Suzanne A. W.; Rechoum, Yassine; Gu, Guowei JAMA Oncology, Vol. 2, Issue 10 https://doi.org/10.1001/jamaoncol.2016.1268	journal	October 2016
Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets Brastianos, Priscilla K.; Carter, Scott L.; Santagata, Sandro Cancer Discovery, Vol. 5, Issue 11 https://doi.org/10.1158/2159-8290.cd-15-0369	journal	September 2015
Who's driving anyway? Herculean efforts to identify the drivers of breast cancer Hartmaier, Ryan J.; Priedigkeit, Nolan; Lee, Adrian V. Breast Cancer Research, Vol. 14, Issue 5 https://doi.org/10.1186/bcr3325	journal	October 2012
Xenografts as Models of Clonal Selection and Acquired Resistance to Therapy Mardis, Elaine R. Clinical Chemistry, Vol. 61, Issue 5 https://doi.org/10.1373/clinchem.2014.237289	journal	May 2015
Genetic alterations of FGF receptors: an emerging field in clinical cancer diagnostics and therapeutics Katoh, Masaru Expert Review of Anticancer Therapy, Vol. 10, Issue 9 https://doi.org/10.1586/era.10.128	journal	September 2010

Cited By (102)

STAT3 in Breast Cancer Onset and Progression: A Matter of Time and Context Segatto, Ilenia; Baldassarre, Gustavo; Belletti, Barbara International Journal of Molecular Sciences, Vol. 19, Issue 9 https://doi.org/10.3390/ijms19092818	journal	September 2018
The microcosmos of intratumor heterogeneity: the space-time of cancer evolution Janiszewska, Michalina Oncogene, Vol. 39, Issue 10 https://doi.org/10.1038/s41388-019-1127-5	journal	November 2019
5-Fluorouracil treatment induces characteristic T>G mutations in human cancer Christensen, Sharon; Van der Roest, Bastiaan; Besselink, Nicolle Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-12594-8	journal	October 2019
Development of Personalized Therapeutic Strategies by Targeting Actionable Vulnerabilities in Metastatic and Chemotherapy-Resistant Breast Cancer PDXs Punzi, Simona; Meliksetian, Marine; Riva, Laura Cells, Vol. 8, Issue 6 https://doi.org/10.3390/cells8060605	journal	June 2019
ESR1 mutations in metastatic lobular breast cancer patients Desmedt, Christine; Pingitore, Julien; Rothé, Françoise npj Breast Cancer, Vol. 5, Issue 1 https://doi.org/10.1038/s41523-019-0104-z	journal	February 2019
Integrative analysis of copy number and gene expression data identifies potential oncogenic drivers that promote mammary tumor recurrence Jones, Robert A.; Moorehead, Roger A. Genes, Chromosomes and Cancer, Vol. 58, Issue 6 https://doi.org/10.1002/gcc.22729	journal	January 2019
CXCR4‐Enriched Nano‐Trap Targeting CXCL12 in Lung for Early Prevention and Enhanced Photodynamic Therapy of Breast Cancer Metastasis Wang, Zhaohui; Ma, Yi; Wang, Han Advanced Functional Materials, Vol. 29, Issue 45 https://doi.org/10.1002/adfm.201905480	journal	September 2019
Patterns of genomic evolution in advanced melanoma Birkeland, E.; Zhang, S.; Poduval, D. Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-05063-1	journal	July 2018
DNA methylation in breast cancers: Differences based on estrogen receptor status and recurrence Williams, Kristin E.; Jawale, Rahul M.; Schneider, Sallie S. Journal of Cellular Biochemistry, Vol. 120, Issue 1 https://doi.org/10.1002/jcb.27431	journal	August 2018
Genomic data analysis workflows for tumors from patient-derived xenografts (PDXs): challenges and guidelines Woo, Xing Yi; Srivastava, Anuj; Graber, Joel H. BMC Medical Genomics, Vol. 12, Issue 1 https://doi.org/10.1186/s12920-019-0551-2	journal	July 2019
Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer von Loga, Katharina; Woolston, Andrew; Punta, Marco Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-019-13915-7	journal	January 2020
Determinants and clinical implications of chromosomal instability in cancer Sansregret, Laurent; Vanhaesebroeck, Bart; Swanton, Charles Nature Reviews Clinical Oncology, Vol. 15, Issue 3 https://doi.org/10.1038/nrclinonc.2017.198	journal	January 2018
Molecular characterisation of aromatase inhibitor-resistant advanced breast cancer: the phenotypic effect of ESR1 mutations Lopez-Knowles, Elena; Pearson, Alex; Schuster, Gene British Journal of Cancer, Vol. 120, Issue 2 https://doi.org/10.1038/s41416-018-0345-x	journal	December 2018
Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer O’Leary, Ben; Hrebien, Sarah; Morden, James P. Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-03215-x	journal	March 2018
Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis Han, Tao; Jiang, Shulong; Zheng, Hong Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-11618-7	journal	August 2019
Organotropism: new insights into molecular mechanisms of breast cancer metastasis Chen, Wenjing; Hoffmann, Andrew D.; Liu, Huiping npj Precision Oncology, Vol. 2, Issue 1 https://doi.org/10.1038/s41698-018-0047-0	journal	February 2018
The evolutionary history of 2,658 cancers Gerstung, Moritz; Jolly, Clemency; Leshchiner, Ignaty Nature, Vol. 578, Issue 7793 https://doi.org/10.1038/s41586-019-1907-7	journal	February 2020
Glucose Transporter 3 Is Essential for the Survival of Breast Cancer Cells in the Brain Kuo, Min-Hsun; Chang, Wen-Wei; Yeh, Bi-Wen Cells, Vol. 8, Issue 12 https://doi.org/10.3390/cells8121568	journal	December 2019
Pan-cancer whole-genome analyses of metastatic solid tumours Priestley, Peter; Baber, Jonathan; Lolkema, Martijn P. Nature, Vol. 575, Issue 7781 https://doi.org/10.1038/s41586-019-1689-y	journal	October 2019
ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response Nagarajan, Sankari; Rao, Shalini V.; Sutton, Joseph Nature Genetics, Vol. 52, Issue 2 https://doi.org/10.1038/s41588-019-0541-5	journal	January 2020
Beyond 5 years: enduring risk of recurrence in oestrogen receptor-positive breast cancer Richman, Juliet; Dowsett, Mitch Nature Reviews Clinical Oncology, Vol. 16, Issue 5 https://doi.org/10.1038/s41571-018-0145-5	journal	December 2018
The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies Angus, Lindsay; Smid, Marcel; Wilting, Saskia M. Nature Genetics, Vol. 51, Issue 10 https://doi.org/10.1038/s41588-019-0507-7	journal	September 2019
Divide and conquer: A perspective on biochips for single-cell and rare-molecule analysis by next-generation sequencing Lee, A. C.; Lee, Y.; Lee, D. APL Bioengineering, Vol. 3, Issue 2 https://doi.org/10.1063/1.5095962	journal	June 2019
Mechanisms of resistance to estrogen receptor modulators in ER+/HER2− advanced breast cancer Zhang, Jin; Wang, Qianying; Wang, Qing Cellular and Molecular Life Sciences, Vol. 77, Issue 4 https://doi.org/10.1007/s00018-019-03281-4	journal	August 2019
Improving Cancer Drug Discovery by Studying Cancer across the Tree of Life Somarelli, Jason A.; Boddy, Amy M.; Gardner, Heather L. Molecular Biology and Evolution, Vol. 37, Issue 1 https://doi.org/10.1093/molbev/msz254	journal	November 2019
Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer Siersbæk, Rasmus; Kumar, Sanjeev; Carroll, Jason S. Genes & Development, Vol. 32, Issue 17-18 https://doi.org/10.1101/gad.316646.118	journal	September 2018
Timing somatic events in the evolution of cancer Jolly, Clemency; Van Loo, Peter Genome Biology, Vol. 19, Issue 1 https://doi.org/10.1186/s13059-018-1476-3	journal	July 2018
PIM1 is responsible for IL-6-induced breast cancer cell EMT and stemness via c-myc activation Gao, Xueqiang; Liu, Xiangping; Lu, Yangyong Breast Cancer, Vol. 26, Issue 5 https://doi.org/10.1007/s12282-019-00966-3	journal	April 2019
Roles of the immune system in cancer: from tumor initiation to metastatic progression Gonzalez, Hugo; Hagerling, Catharina; Werb, Zena Genes & Development, Vol. 32, Issue 19-20 https://doi.org/10.1101/gad.314617.118	journal	October 2018
Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor Amrutkar, Manoj; Larsen, Emma Kristine; Aasrum, Monica Cells, Vol. 9, Issue 1 https://doi.org/10.3390/cells9010227	journal	January 2020
The JAK2 V617F mutation in breast cancer? Langabeer, Stephen E. The Breast Journal, Vol. 26, Issue 3 https://doi.org/10.1111/tbj.13683	journal	March 2020
GOLPH3: a Golgi phosphatidylinositol(4)phosphate effector that directs vesicle trafficking and drives cancer Kuna, Ramya S.; Field, Seth J. Journal of Lipid Research, Vol. 60, Issue 2 https://doi.org/10.1194/jlr.r088328	journal	September 2018
BCMA (TNFRSF17) Induces APRIL and BAFF Mediated Breast Cancer Cell Stemness Pelekanou, Vasiliki; Notas, George; Athanasouli, Paraskevi Frontiers in Oncology, Vol. 8 https://doi.org/10.3389/fonc.2018.00301	journal	August 2018
Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes Koedoot, Esmee; Fokkelman, Michiel; Rogkoti, Vasiliki-Maria Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-11020-3	journal	July 2019
Coexisting genomic aberrations associated with lymph node metastasis in breast cancer Bao, Li; Qian, Zhaoyang; Lyng, Maria B. Journal of Clinical Investigation, Vol. 128, Issue 6 https://doi.org/10.1172/jci97449	journal	April 2018
TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis Woosley, Alec N.; Dalton, Annamarie C.; Hussey, George S. Oncogene, Vol. 38, Issue 20 https://doi.org/10.1038/s41388-019-0703-z	journal	January 2019
Molecular Biology and Evolution of Cancer: From Discovery to Action Somarelli, Jason A.; Gardner, Heather; Cannataro, Vincent L. Molecular Biology and Evolution, Vol. 37, Issue 2 https://doi.org/10.1093/molbev/msz242	journal	October 2019
Targeting of JAK-STAT Signaling in Breast Cancer: Therapeutic Strategies to Overcome Drug Resistance Tabassum, Sobia; Abbasi, Rashda; Ahmad, Nafees Breast Cancer Metastasis and Drug Resistance: Challenges and Progress, p. 271-281 https://doi.org/10.1007/978-3-030-20301-6_14	book	August 2019
Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer Patten, Darren K.; Corleone, Giacomo; Győrffy, Balázs Nature Medicine, Vol. 24, Issue 9 https://doi.org/10.1038/s41591-018-0091-x	journal	July 2018
Novel and Alternative Targets Against Breast Cancer Stemness to Combat Chemoresistance Sridharan, Sangita; Howard, Cory M.; Tilley, Augustus M. C. Frontiers in Oncology, Vol. 9 https://doi.org/10.3389/fonc.2019.01003	journal	October 2019
CUTseq is a versatile method for preparing multiplexed DNA sequencing libraries from low-input samples Zhang, Xiaolu; Garnerone, Silvano; Simonetti, Michele Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-12570-2	journal	October 2019
Endocrine Resistance in Hormone Receptor Positive Breast Cancer–From Mechanism to Therapy Rani, Aradhana; Stebbing, Justin; Giamas, Georgios Frontiers in Endocrinology, Vol. 10 https://doi.org/10.3389/fendo.2019.00245	journal	May 2019
NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer Dischinger, Patrick S.; Tovar, Elizabeth A.; Essenburg, Curt J. npj Breast Cancer, Vol. 4, Issue 1 https://doi.org/10.1038/s41523-018-0080-8	journal	August 2018
Untargeted Assessment of Tumor Fractions in Plasma for Monitoring and Prognostication from Metastatic Breast Cancer Patients Undergoing Systemic Treatment Suppan, Christoph; Brcic, Iva; Tiran, Verena Cancers, Vol. 11, Issue 8 https://doi.org/10.3390/cancers11081171	journal	August 2019
Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy Parkin, Ashleigh; Man, Jennifer; Timpson, Paul The FEBS Journal, Vol. 286, Issue 18 https://doi.org/10.1111/febs.15011	journal	August 2019
Liquid biopsy for HER2-positive breast cancer brain metastasis: the role of the cerebrospinal fluid De Mattos-Arruda, Leticia ESMO Open, Vol. 2, Issue 4 https://doi.org/10.1136/esmoopen-2017-000270	journal	October 2017
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig Rubanova, Yulia; Shi, Ruian; Harrigan, Caitlin F. Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-14352-7	journal	February 2020
High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer Echeverria, Gloria V.; Powell, Emily; Seth, Sahil Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-07406-4	journal	November 2018
Tumor-Targeted and Biocompatible MoSe2 Nanodots@Albumin Nanospheres as a Dual-Modality Therapy Agent for Synergistic Photothermal Radiotherapy Qi, Feng; Liu, Ruizhen Nanoscale Research Letters, Vol. 14, Issue 1 https://doi.org/10.1186/s11671-019-2896-z	journal	February 2019
Quantitative evidence for early metastatic seeding in colorectal cancer Hu, Zheng; Ding, Jie; Ma, Zhicheng Nature Genetics, Vol. 51, Issue 7 https://doi.org/10.1038/s41588-019-0423-x	journal	June 2019
Breast cancer Harbeck, Nadia; Penault-Llorca, Frédérique; Cortes, Javier Nature Reviews Disease Primers, Vol. 5, Issue 1 https://doi.org/10.1038/s41572-019-0111-2	journal	September 2019
High-resolution deconstruction of evolution induced by chemotherapy treatments in breast cancer xenografts Kim, Hyunsoo; Kumar, Pooja; Menghi, Francesca Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-36184-8	journal	December 2018
Ampelopsin E Reduces the Invasiveness of the Triple Negative Breast Cancer Cell Line, MDA-MB-231 Tieng, Francis Yew Fu; Latifah, Saiful Yazan; Md Hashim, Nur Fariesha Molecules, Vol. 24, Issue 14 https://doi.org/10.3390/molecules24142619	journal	July 2019
KRT19 and CEACAM5 mRNA-marked circulated tumor cells indicate unfavorable prognosis of breast cancer patients Wang, Xi-Mei; Zhang, Zhen; Pan, Li-Hui Breast Cancer Research and Treatment, Vol. 174, Issue 2 https://doi.org/10.1007/s10549-018-05069-9	journal	December 2018
Moving Breast Cancer Therapy up a Notch Mollen, Erik W. J.; Ient, Jonathan; Tjan-Heijnen, Vivianne C. G. Frontiers in Oncology, Vol. 8 https://doi.org/10.3389/fonc.2018.00518	journal	November 2018
Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness Sridharan, Sangita; Robeson, Megan; Bastihalli-Tukaramrao, Diwakar Frontiers in Oncology, Vol. 9 https://doi.org/10.3389/fonc.2019.01311	journal	December 2019
Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients Chatterjee, Gaurav; Pai, Trupti; Hardiman, Thomas Breast Cancer Research, Vol. 20, Issue 1 https://doi.org/10.1186/s13058-018-1070-3	journal	November 2018
Genomic characterization of metastatic breast cancers Bertucci, François; Ng, Charlotte K. Y.; Patsouris, Anne Nature, Vol. 569, Issue 7757 https://doi.org/10.1038/s41586-019-1056-z	journal	May 2019
Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia Li, Benshang; Brady, Samuel W.; Ma, Xiaotu Blood, Vol. 135, Issue 1 https://doi.org/10.1182/blood.2019002220	journal	January 2020
Blockade of TLR4 using TAK-242 (resatorvid) enhances anti-cancer effects of chemotherapeutic agents: a novel synergistic approach for breast and ovarian cancers Kashani, Bahareh; Zandi, Zahra; Karimzadeh, Mohammad Reza Immunologic Research, Vol. 67, Issue 6 https://doi.org/10.1007/s12026-019-09113-8	journal	December 2019
Tailored NEOadjuvant epirubicin, cyclophosphamide and Nanoparticle Albumin-Bound paclitaxel for breast cancer: The phase II NEONAB trial—Clinical outcomes and molecular determinants of response Murphy, Caitlin; Muscat, Andrea; Ashley, David PLOS ONE, Vol. 14, Issue 2 https://doi.org/10.1371/journal.pone.0210891	journal	February 2019
Genetic insights into the morass of metastatic heterogeneity Hunter, Kent W.; Amin, Ruhul; Deasy, Sarah Nature Reviews Cancer, Vol. 18, Issue 4 https://doi.org/10.1038/nrc.2017.126	journal	February 2018
KRT19 and CEACAM5 mRNA-marked circulated tumor cells indicate unfavorable prognosis of breast cancer patients Wang, X.; Zhang, Z.; Pan, L. The Breast, Vol. 44 https://doi.org/10.1016/s0960-9776(19)30317-0	journal	March 2019
Genetic and transcriptional evolution alters cancer cell line drug response Ben-David, Uri; Siranosian, Benjamin; Ha, Gavin Nature, Vol. 560, Issue 7718 https://doi.org/10.1038/s41586-018-0409-3	journal	August 2018
ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response. Nagarajan, Sankari; Rao, Shalini V.; Sutton, Joseph Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.45936	text	January 2020
The evolutionary history of 2,658 cancers. Gerstung, Moritz; Jolly, Clemency; Leshchiner, Ignaty Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.50319	text	January 2020
Molecular biology and evolution of cancer: from discovery to action. Somarelli, Jason A.; Gardner, Heather; Cannataro, Vincent L. The Francis Crick Institute https://doi.org/10.25418/crick.11848359.v1	text	January 2020
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. Rubanova, Yulia; Shi, Ruian; Harrigan, Caitlin F. The Francis Crick Institute https://doi.org/10.25418/crick.11876955.v1	text	January 2020
Genomic characterization of metastatic breast cancers. Bertucci, François; Ng, Kiu Yan Charlotte; Patsouris, Anne Springer Nature https://doi.org/10.7892/boris.136299	text	January 2019
The JAK2 V617F mutation in breast cancer? Naeem, Mohammad Abdul The Breast Journal, Vol. 26, Issue 3 https://doi.org/10.1111/tbj.13688	journal	March 2020
Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer. Siersbæk, Rasmus; Kumar, Sanjeev; Carroll, Jason Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.39793	text	January 2018
The evolutionary history of 2,658 cancers. Gerstung, Moritz; Jolly, Clemency; Leshchiner, Ignaty Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.64274	text	January 2020
The evolutionary history of 2,658 cancers. Gerstung, Moritz; Jolly, Clemency; Leshchiner, Ignaty The Francis Crick Institute https://doi.org/10.25418/crick.11842797.v1	text	January 2020
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. Rubanova, Yulia; Shi, Ruian; Harrigan, Caitlin F. The Francis Crick Institute https://doi.org/10.25418/crick.11876955	text	January 2020
Quantifying local malignant adaptation in tissue‐specific evolutionary trajectories by harnessing cancer’s repeatability at the genetic level Tokutomi, Natsuki; Moyret‐Lalle, Caroline; Puisieux, Alain Evolutionary Applications, Vol. 12, Issue 5 https://doi.org/10.1111/eva.12781	journal	January 2019
The evolutionary history of 2,658 cancers. Gerstung, Moritz; Jolly, Clemency; Leshchiner, Ignaty The Francis Crick Institute https://doi.org/10.25418/crick.11842797	text	January 2020
The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers Razavi, Pedram; Chang, Matthew T.; Xu, Guotai Cancer Cell, Vol. 34, Issue 3 https://doi.org/10.1016/j.ccell.2018.08.008	journal	September 2018
Multi-regional Sequencing Elucidates the Evolution of Clear Cell Renal Cell Carcinoma Ricketts, Christopher J.; Linehan, W. Marston Cell, Vol. 173, Issue 3 https://doi.org/10.1016/j.cell.2018.03.077	journal	April 2018
Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis Petljak, Mia; Alexandrov, Ludmil B.; Brammeld, Jonathan S. Cell, Vol. 176, Issue 6 https://doi.org/10.1016/j.cell.2019.02.012	journal	March 2019
The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer De Mattos-Arruda, Leticia; Sammut, Stephen-John; Ross, Edith M. Cell Reports, Vol. 27, Issue 9 https://doi.org/10.1016/j.celrep.2019.04.098	journal	May 2019
Dynamic Emergence of Observed and Hidden Intra-tumor Heterogeneity Raynaud, Franck; Mina, Marco; Ciriello, Giovanni iScience, Vol. 21 https://doi.org/10.1016/j.isci.2019.10.018	journal	November 2019
Establishment and characterization of paired primary cultures of human pancreatic cancer cells and stellate cells derived from the same tumor Amrutkar, M.; Larsen, E.; Aasrum, M. Pancreatology, Vol. 20 https://doi.org/10.1016/j.pan.2020.07.243	journal	November 2020
Elucidating therapeutic molecular targets in premenopausal Asian women with recurrent breast cancers Yap, Y. S.; Singh, A.; Lim, J. H. C. European Journal of Cancer, Vol. 92 https://doi.org/10.1016/s0959-8049(18)30653-1	journal	April 2018
Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development Dorssers, Lambert C. J.; Gillis, Ad J. M.; Stoop, Hans British Journal of Cancer, Vol. 120, Issue 4 https://doi.org/10.1038/s41416-019-0381-1	journal	February 2019
Induction of 3-hydroxy-3-methylglutaryl-CoA reductase mediates statin resistance in breast cancer cells Göbel, Andy; Breining, Dorit; Rauner, Martina Cell Death & Disease, Vol. 10, Issue 2 https://doi.org/10.1038/s41419-019-1322-x	journal	January 2019
Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking Cresswell, George D.; Nichol, Daniel; Spiteri, Inmaculada Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-15047-9	journal	March 2020
Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments Janiszewska, Michalina; Tabassum, Doris P.; Castaño, Zafira Nature Cell Biology, Vol. 21, Issue 7 https://doi.org/10.1038/s41556-019-0346-x	journal	July 2019
Does early metastatic seeding occur in colorectal cancer? Magrì, Alessandro; Bardelli, Alberto Nature Reviews Gastroenterology & Hepatology, Vol. 16, Issue 11 https://doi.org/10.1038/s41575-019-0200-4	journal	August 2019
The Omics Revolution Continues: The Maturation of High-Throughput Biological Data Sources Mathé, Ewy; Hays, John; Stover, Daniel Yearbook of Medical Informatics, Vol. 27, Issue 01 https://doi.org/10.1055/s-0038-1667085	journal	August 2018
PRISM: methylation pattern-based, reference-free inference of subclonal makeup Lee, Dohoon; Lee, Sangseon; Kim, Sun Bioinformatics, Vol. 35, Issue 14 https://doi.org/10.1093/bioinformatics/btz327	journal	July 2019
Cooperation among Tumor Cell Subpopulations Leads to Intratumor Heterogeneity Li, Xin; Thirumalai, D. Biophysical Reviews and Letters, Vol. 15, Issue 02 https://doi.org/10.1142/s1793048020300042	journal	June 2020
Separating the Local and Malignant Dimensions of Cancer Adaptation Roche, Benjamin; Martinez, Pierre Cancer Informatics, Vol. 18 https://doi.org/10.1177/1176935119872954	journal	January 2019
The role of poly(ADP-ribose) polymerase inhibitors in the treatment of cancer and methods to overcome resistance: a review Patel, Mausam; Nowsheen, Somaira; Maraboyina, Sanjay Cell & Bioscience, Vol. 10, Issue 1 https://doi.org/10.1186/s13578-020-00390-7	journal	March 2020
Pan-cancer inference of intra-tumor heterogeneity reveals associations with different forms of genomic instability Raynaud, Franck; Mina, Marco; Tavernari, Daniele PLOS Genetics, Vol. 14, Issue 9 https://doi.org/10.1371/journal.pgen.1007669	journal	September 2018
Constitutional Mosaic Epimutations – a hidden cause of cancer? Lønning, Per E.; Eikesdal, Hans P.; Løes, Inger M. Cell Stress, Vol. 3, Issue 4 https://doi.org/10.15698/cst2019.04.183	journal	April 2019
‘Omics Approaches to Explore the Breast Cancer Landscape Parsons, Joseph; Francavilla, Chiara Frontiers in Cell and Developmental Biology, Vol. 7 https://doi.org/10.3389/fcell.2019.00395	journal	January 2020
Landscape of CDKN1B Mutations in Luminal Breast Cancer and Other Hormone-Driven Human Tumors Cusan, Martina; Mungo, Giorgia; De Marco Zompit, Mara Frontiers in Endocrinology, Vol. 9 https://doi.org/10.3389/fendo.2018.00393	journal	July 2018
Phylogenetic Tree Inference: A Top-Down Approach to Track Tumor Evolution Wu, Pin; Hou, Linjun; Zhang, Yingdong Frontiers in Genetics, Vol. 10 https://doi.org/10.3389/fgene.2019.01371	journal	February 2020
Targeting Genome Stability in Melanoma—A New Approach to an Old Field Osrodek, Marta; Wozniak, Michal International Journal of Molecular Sciences, Vol. 22, Issue 7 https://doi.org/10.3390/ijms22073485	journal	March 2021
A proteomic analysis of chemoresistance development via sequential treatment with doxorubicin reveals novel players in MCF‑7 breast cancer cells Sommer, Ann‑Katrin; Hermawan, Adam; Ljepoja, Bojan International Journal of Molecular Medicine https://doi.org/10.3892/ijmm.2018.3781	journal	July 2018
Outcome of Omani Women with Breast Cancer-associated Brain Metastases Experience from a University Hospital Zahid, Khawaja F.; Kumar, Shiyam; Al-Bimani, Khalid Oman Medical Journal, Vol. 34, Issue 5 https://doi.org/10.5001/omj.2019.76	journal	September 2019
Phase I/II clinical trial of everolimus combined with gemcitabine/cisplatin for metastatic triple-negative breast cancer Park, In Hae; Kong, Sun-Young; Kwon, Youngmee Journal of Cancer, Vol. 9, Issue 7 https://doi.org/10.7150/jca.24035	journal	January 2018

Similar Records

Genetic evolution of breast cancer from primary tumors to distant metastases evaluated by comparative genomic hybridization

Journal Article · Thu Sep 01 00:00:00 EDT 1994 · American Journal of Human Genetics · OSTI ID:1392804

Kallioniemi, O P; Hyytinen, E; Karhu, R

Evaluation of Vascular Endothelial Growth Factor as a Prognostic Marker for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast-Conserving Therapy

Journal Article · Thu Dec 01 00:00:00 EST 2011 · International Journal of Radiation Oncology, Biology and Physics · OSTI ID:1392804

Qifeng, Yang; Goyal, Sharad; Harris, Lyndsay; +2 more

SU-E-J-115: Using Markov Chain Modeling to Elucidate Patterns in Breast Cancer Metastasis Over Time and Space

Journal Article · Sun Jun 01 00:00:00 EDT 2014 · Medical Physics · OSTI ID:1392804

Comen, E; Mason, J; Kuhn, P; +5 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
Biological Science
breast cancer
metastasis
relapse
genomics
somatic mutation

Title: Genomic Evolution of Breast Cancer Metastasis and Relapse

Citation Formats

References (59)

Cited By (102)

Similar Records

Related Subjects