Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling

Blundon, Jay A.; Roy, Noah C.; Teubner, Brett J.  W.; Yu, Jing; Eom, Tae-Yeon; Sample, K. Jake; Pani, Amar; Smeyne, Richard J.; Han, Seung Baek; Kerekes, Ryan A.; Rose, Derek C.; Hackett, Troy A.; Vuppala, Pradeep K.; Freeman, Burgess B.; Zakharenko, Stanislav S.

doi:10.1126/science.aaf4612

Title: Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling

Journal Article · Fri Jun 30 00:00:00 EDT 2017 · Science

DOI:https://doi.org/10.1126/science.aaf4612· OSTI ID:1376640

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St.Jude Children's Research Hospital, Memphis, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Vanderbilt Univ., Nashville, TN (United States)
St. Jude Children's Hospital, Memphis, TN (United States)

Circuits in the auditory cortex are highly susceptible to acoustic influences during an early postnatal critical period. The auditory cortex selectively expands neural representations of enriched acoustic stimuli, a process important for human language acquisition. Adults lack this plasticity. We show in the murine auditory cortex that juvenile plasticity can be reestablished in adulthood if acoustic stimuli are paired with disruption of ecto-5'-nucleotidase–dependent adenosine production or A1–adenosine receptor signaling in the auditory thalamus. This plasticity occurs at the level of cortical maps and individual neurons in the auditory cortex of awake adult mice and is associated with long-term improvement of tone-discrimination abilities. We determined that, in adult mice, disrupting adenosine signaling in the thalamus rejuvenates plasticity in the auditory cortex and improves auditory perception.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1376640

Journal Information:: Science, Vol. 356, Issue 6345; ISSN 0036-8075

Publisher:: AAASCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 28 works

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