Spatial biomarker of disease and detection of spatial organization of cellular receptors

Salaita, Khalid S.; Nair, Pradeep M.; Das, Debopriya; Gray, Joe W.; Groves, John T.

Title: Spatial biomarker of disease and detection of spatial organization of cellular receptors

Patent · Tue Jul 18 00:00:00 EDT 2017

OSTI ID:1371905

Salaita, Khalid S.; Nair, Pradeep M.; Das, Debopriya; Gray, Joe W.; Groves, John T.

A signature of a condition of a live cell is established in an assay that allows distribution of the receptors on the cell surface in response to binding a ligand. The receptors can be optically detected and quantified to provide a value for the condition, Test drugs can be screened for therapeutic potential in the assay: a potentially efficacious drug is identified by an ability to modulate an established signature. The receptor distribution signature can be corroborated with an mRNA expression profile of several genes, indicating, for example, metastasis.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California

Patent Number(s):: 9,708,665

Application Number:: The Regents of the University of California

OSTI ID:: 1371905

Resource Relation:: Patent File Date: 2011 Jul 29

Country of Publication:: United States

Language:: English

References (47)

Sensor membranes Raguse, Burkhard; Cornell, Bruce A.; Braach-Maksvytis, Vijoleta Lucija Bronislava https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5637201 US Patent Document 5,637,201	patent	June 1997
Bilayer stabilizing components and their use in forming programmable fusogenic liposomes Holland, John W.; Madden, Thomas D.; Cullis, Pieter R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5885613 US Patent Document 5,885,613	patent	March 1999
Surface immobilization of biopolymers Tarlov, Michael J.; Herne, Tonya M.; McKenney, Keith H. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5942397 US Patent Document 5,942,397	patent	August 1999
Arrays of independently-addressable supported fluid bilayer membranes Boxer, Steven; Ulman, Nick; Groves, Jay T. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6228326 US Patent Document 6,228,326	patent	May 2001
Arrays of protein-capture agents and methods of use thereof Wagner, Peter; Nock, Steffen; Ault-Riche, Dana https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6329209 US Patent Document 6,329,209	patent	December 2001
Modulation of cellular adhesion with lipid membrane micro-arrays Groves, John T.; Mahal, Lara K.; Bertozzi, Carolyn R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20020160505 US Patent Application 10/076727; 20020160505	patent-application	October 2002
Membrane-based assays Yamazaki, Miki; Schafer, Robert J.; Ulman, Morrison https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040053337 US Patent Application 10/661790; 20040053337	patent-application	March 2004
Membrane architectures for ion-channel switch-based electrochemical biosensors Sansinena, Jose-Maria; Redondo, Antonio; Swanson, Basil I. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050244487 US Patent Application 11/072720; 20050244487	patent-application	November 2005
Compositions And Methods For Treating And Diagnosing Cancer Clarke, Michael F.; Liu, Rui https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080292546 US Patent Application 12/127636; 20080292546	patent-application	November 2008
Fluid Membrane-Based Ligand Display System for Live Cell Assays and Disease Diagnosis Applications Nam, Jwa-Min; Nair, Pradeep M.; Neve, Richard M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090011428 US Patent Application 12/161553; 20090011428	patent-application	January 2009
Systems And Methods For Predicting Response Of Biological Samples Gray, Joe W.; Das, Debopriya; Wang, Nicholas https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090177450 US Patent Application 12/333192; 20090177450	patent-application	July 2009
Modulators Of EphA2 And Ephrina1 For The Treatment Of Fibrosis-Related Disease Kinch, Michael S.; Carles-Kinch, Kelly https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120121582 US Patent Application 13/014005; 20120121582	patent-application	May 2012
Compositions and Methods for Treating and Diagnosing Cancer Clarke, Michael F.; Liu, Rui https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120315216 US Patent Application 13/556875; 20120315216	patent-application	December 2012
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Pasquale, Elena B. Cell, Vol. 133, Issue 1 https://doi.org/10.1016/j.cell.2008.03.011	journal	April 2008
Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization Provenzano, Paolo P.; Inman, David R.; Eliceiri, Kevin W. Biophysical Journal, Vol. 95, Issue 11 https://doi.org/10.1529/biophysj.108.133116	journal	December 2008
Architecture and Function of Membrane Proteins in Planar Supported Bilayers: A Study with Photosynthetic Reaction Centers Salafsky, Joshua; Groves, Jay T.; Boxer, Steven G. Biochemistry, Vol. 35, Issue 47, p. 14773-14781 https://doi.org/10.1021/bi961432i	journal	January 1996
Statistical significance for genomewide studies Storey, J. D.; Tibshirani, R. Proceedings of the National Academy of Sciences, Vol. 100, Issue 16, p. 9440-9445 https://doi.org/10.1073/pnas.1530509100	journal	July 2003
Kinase-Dependent and -Independent Roles of EphA2 in the Regulation of Prostate Cancer Invasion and Metastasis Taddei, Maria Letizia; Parri, Matteo; Angelucci, Adriano The American Journal of Pathology, Vol. 174, Issue 4 https://doi.org/10.2353/ajpath.2009.080473	journal	April 2009
EphA2 Expression Is Associated with Aggressive Features in Ovarian Carcinoma Thaker, P. H.; Deavers, Michael; Celestino, Joseph Clinical Cancer Research, Vol. 10, Issue 15, p. 5145-5150 https://doi.org/10.1158/1078-0432.CCR-03-0589	journal	August 2004
An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor Zhang, Xuewu; Gureasko, Jodi; Shen, Kui Cell, Vol. 125, Issue 6 https://doi.org/10.1016/j.cell.2006.05.013	journal	June 2006
From The Cover: Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens Bailey, S. N.; Sabatini, D. M.; Stockwell, B. R. Proceedings of the National Academy of Sciences, Vol. 101, Issue 46, p. 16144-16149 https://doi.org/10.1073/pnas.0404425101	journal	November 2004
Nanodiscs separate chemoreceptor oligomeric states and reveal their signaling properties Boldog, T.; Grimme, S.; Li, M. Proceedings of the National Academy of Sciences, Vol. 103, Issue 31, p. 11509-11514 https://doi.org/10.1073/pnas.0604988103	journal	July 2006
Molecular transport and organization in supported lipid membranes Boxer, S. Current Opinion in Chemical Biology, Vol. 4, Issue 6 https://doi.org/10.1016/S1367-5931(00)00139-3	journal	December 2000
Mechanotransduction - a field pulling together? Chen, C. S. Journal of Cell Science, Vol. 121, Issue 20, p. 3285-3292 https://doi.org/10.1242/jcs.023507	journal	October 2008
Adaptively inferring human transcriptional subnetworks Das, Debopriya; Nahlé, Zaher; Zhang, Michael Q Molecular Systems Biology, Vol. 2, Issue 1, Article No. 0029 https://doi.org/10.1038/msb4100067	journal	June 2006
T Cell Receptor Microcluster Transport through Molecular Mazes Reveals Mechanism of Translocation DeMond, Andrew L.; Mossman, Kaspar D.; Starr, Toby Biophysical Journal, Vol. 94, Issue 8 https://doi.org/10.1529/biophysj.107.119099	journal	April 2008
DAVID: Database for Annotation, Visualization, and Integrated Discovery Dennis, Glynn; Sherman, Brad T.; Hosack, Douglas A. Genome Biology, Vol. 4, Issue 9, Article No. R60 https://doi.org/10.1186/gb-2003-4-9-r60	journal	January 2003
Tissue Cells Feel and Respond to the Stiffness of Their Substrate Discher, D. E.; Janmey, Paul; Wang, Yu-li Science, Vol. 310, Issue 5751, p. 1139-1143 https://doi.org/10.1126/science.1116995	journal	November 2005
Antiangiogenic and Antitumor Efficacy of EphA2 Receptor Antagonist Dobrzanski, Pawel; Hunter, Kathryn; Jones-Bolin, Susan Cancer Research, Vol. 64, Issue 3, p. 910-919 https://doi.org/10.1158/0008-5472.CAN-3430-2	journal	February 2004
Origins of Cell Polarity Drubin, David G.; Nelson, W. James Cell, Vol. 84, Issue 3 https://doi.org/10.1016/S0092-8674(00)81278-7	journal	February 1996
Quantitative Fluorescence Microscopy Using Supported Lipid Bilayer Standards Galush, William J.; Nye, Jeffrey A.; Groves, Jay T. Biophysical Journal, Vol. 95, Issue 5 https://doi.org/10.1529/biophysj.108.131540	journal	September 2008
Micropattern Formation in Supported Lipid Membranes Groves, Jay T.; Boxer, Steven G. Accounts of Chemical Research, Vol. 35, Issue 3, p. 149-157 https://doi.org/10.1021/ar950039m	journal	March 2002
Using plasma membrane nanoclusters to build better signaling circuits Harding, Angus S.; Hancock, John F. Trends in Cell Biology, Vol. 18, Issue 8 https://doi.org/10.1016/j.tcb.2008.05.006	journal	August 2008
Regulated Cleavage of a Contact-Mediated Axon Repellent Hattori, M.; Osterfield, Miriam; Flanagan, John G. Science, Vol. 289, Issue 5483, p. 1360-1365 https://doi.org/10.1126/science.289.5483.1360	journal	August 2000
Crystal structure of an Eph receptor–ephrin complex Himanen, Juha-Pekka; Rajashankar, Kanagalaghatta R.; Lackmann, Martin Nature, Vol. 414, Issue 6866, p. 933-938 https://doi.org/10.1038/414933a	journal	December 2001
Integrin ligands at a glance Humphries, J. D.; Byron, Adam; Humphries, Martin J. Journal of Cell Science, Vol. 119, Issue 19, p. 3901-3903 https://doi.org/10.1242/jcs.03098	journal	October 2006
EphA2 Receptor Tyrosine Kinase as a Promising Target for Cancer Therapeutics Ireton, Renee; Chen, Jin Current Cancer Drug Targets, Vol. 5, Issue 3 https://doi.org/10.2174/1568009053765780	journal	May 2005
Scanning Probe Lithography on Fluid Lipid Membranes Jackson, Bryan L.; Groves, Jay T. Journal of the American Chemical Society, Vol. 126, Issue 43, p. 13878-13879 https://doi.org/10.1021/ja046040a	journal	November 2004
Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans Janes, Peter W.; Saha, Nayanendu; Barton, William A. Cell, Vol. 123, Issue 2 https://doi.org/10.1016/j.cell.2005.08.014	journal	October 2005
An Ephrin Mimetic Peptide That Selectively Targets the EphA2 Receptor Koolpe, Mitchell; Dail, Monique; Pasquale, Elena B. Journal of Biological Chemistry, Vol. 277, Issue 49, p. 46974-46979 https://doi.org/10.1074/jbc.M208495200	journal	September 2002
Mechanisms and functions of eph and ephrin signalling Kullander, Klas; Klein, Rüdiger Nature Reviews Molecular Cell Biology, Vol. 3, Issue 7, p. 475-486 https://doi.org/10.1038/nrm856	journal	July 2002
Efficacy and Antivascular Effects of EphA2 Reduction With an Agonistic Antibody in Ovarian Cancer Landen, Charles N.; Lu, Chunhua; Han, Liz Y. JNCI: Journal of the National Cancer Institute, Vol. 98, Issue 21 https://doi.org/10.1093/jnci/djj414	journal	November 2006
A conditional feedback loop regulates Ras activity through EphA2 Macrae, Madhu; Neve, Richard M.; Rodriguez-Viciana, Pablo Cancer Cell, Vol. 8, Issue 2 https://doi.org/10.1016/j.ccr.2005.07.005	journal	August 2005
Nanomagnetic actuation of receptor-mediated signal transduction Mannix, Robert J.; Kumar, Sanjay; Cassiola, Flávia Nature Nanotechnology, Vol. 3, Issue 1, p. 36-40 https://doi.org/10.1038/nnano.2007.418	journal	December 2007
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation Maretzky, T.; Reiss, K.; Ludwig, A. Proceedings of the National Academy of Sciences, Vol. 102, Issue 26, p. 9182-9187 https://doi.org/10.1073/pnas.0500918102	journal	June 2005
A Fluid Membrane-Based Soluble Ligand-Display System for Live-Cell Assays Nam, Jwa-Min; Nair, Pradeep M.; Neve, Richard M. ChemBioChem, Vol. 7, Issue 3, p. 436-440 https://doi.org/10.1002/cbic.200500479	journal	February 2006
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes Neve, Richard M.; Chin, Koei; Fridlyand, Jane Cancer Cell, Vol. 10, Issue 6 https://doi.org/10.1016/j.ccr.2006.10.008	journal	December 2006

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