Use of Accelerator Mass Spectrometry in Human Health and Molecular Toxicology

Enright, Heather A.; Malfatti, Michael A.; Zimmermann, Maike; Ognibene, Ted; Henderson, Paul; Turteltaub, Kenneth W.

doi:10.1021/acs.chemrestox.6b00234

Title: Use of Accelerator Mass Spectrometry in Human Health and Molecular Toxicology

Journal Article · Tue Oct 11 00:00:00 EDT 2016 · Chemical Research in Toxicology

DOI:https://doi.org/10.1021/acs.chemrestox.6b00234· OSTI ID:1367988

Enright, Heather A. ^[1]; Malfatti, Michael A. ^[1]; Zimmermann, Maike ^[2]; Ognibene, Ted ^[1]; Henderson, Paul ^[2]; Turteltaub, Kenneth W. ^[1]

Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
UC Davis Medical Center, Sacramento, CA (United States); Accelerated Medical Diagnostics Inc., Berkeley, CA (United States)

Accelerator mass spectrometry (AMS) has been adopted as a powerful bioanalytical method for human studies in the areas of pharmacology and toxicology. The exquisite sensitivity (10–18 mol) of AMS has facilitated studies of toxins and drugs at environmentally and physiologically relevant concentrations in humans. Such studies include risk assessment of environmental toxicants, drug candidate selection, absolute bioavailability determination, and more recently, assessment of drug-target binding as a biomarker of response to chemotherapy. Combining AMS with complementary capabilities such as high performance liquid chromatography (HPLC) can maximize data within a single experiment and provide additional insight when assessing drugs and toxins, such as metabolic profiling. Recent advances in the AMS technology at Lawrence Livermore National Laboratory have allowed for direct coupling of AMS with complementary capabilities such as HPLC via a liquid sample moving wire interface, offering greater sensitivity compared to that of graphite-based analysis, therefore enabling the use of lower ¹⁴C and chemical doses, which are imperative for clinical testing. In conclusion, the aim of this review is to highlight the recent efforts in human studies using AMS, including technological advancements and discussion of the continued promise of AMS for innovative clinical based research.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

Grant/Contract Number:: AC52-07NA27344; HHSN261201000133C; HHSN261201200048C; HHSN261201200084C

OSTI ID:: 1367988

Report Number(s):: LLNL-JRNL-696717

Journal Information:: Chemical Research in Toxicology, Vol. 29, Issue 12; ISSN 0893-228X

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 8 works

Citation information provided by
Web of Science

References (82)

Applications of accelerator mass spectrometry for pharmacological and toxicological research Brown, Karen; Tompkins, Elaine M.; White, Ian N. H. Mass Spectrometry Reviews, Vol. 25, Issue 1 https://doi.org/10.1002/mas.20059	journal	January 2005
A microdose study of 14C-AR-709 in healthy men: pharmacokinetics, absolute bioavailability and concentrations in key compartments of the lung Lappin, G.; Boyce, M. J.; Matzow, T. European Journal of Clinical Pharmacology, Vol. 69, Issue 9 https://doi.org/10.1007/s00228-013-1528-2	journal	June 2013
Pediatric microdose and microtracer studies using ¹⁴ C in Europe Turner, Ma; Mooij, Mg; Vaes, Whj Clinical Pharmacology & Therapeutics, Vol. 98, Issue 3 https://doi.org/10.1002/cpt.163	journal	July 2015
Direct Coupling of an Elemental Analyzer and a Hybrid Ion Source for AMS Measurements Uhl, Thomas; Kretschmer, Wolfgang; Luppold, Wolfgang Radiocarbon, Vol. 46, Issue 1 https://doi.org/10.1017/S0033822200039369	journal	January 2004
Big physics, small doses: the use of AMS and PET in human microdosing of development drugs Lappin, Graham; Garner, R. Colin Nature Reviews Drug Discovery, Vol. 2, Issue 3 https://doi.org/10.1038/nrd1037	journal	March 2003
The resurgence of platinum-based cancer chemotherapy Kelland, Lloyd Nature Reviews Cancer, Vol. 7, Issue 8 https://doi.org/10.1038/nrc2167	journal	July 2007
Comparison of DNA‐adduct and tissue‐available dose levels of MeIQx in human and rodent colon following administration of a very low dose Mauthe, Robert J.; Dingley, Karen H.; Leveson, Steven H. International Journal of Cancer, Vol. 80, Issue 4 https://doi.org/10.1002/(SICI)1097-0215(19990209)80:4<539::AID-IJC10>3.3.CO;2-3	journal	February 1999
The Urinary Metabolite Profile of the Dietary Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5- b ]Pyridine Is Predictive of Colon DNA Adducts after a Low-Dose Exposure in Humans Malfatti, Michael A.; Dingley, Karen H.; Nowell-Kadlubar, Susan Cancer Research, Vol. 66, Issue 21 https://doi.org/10.1158/0008-5472.CAN-06-1573	journal	November 2006
Pharmacokinetic Investigation of Imatinib Using Accelerator Mass Spectrometry in Patients with Chronic Myeloid Leukemia Boddy, Alan V.; Sludden, Julieann; Griffin, Melanie J. Clinical Cancer Research, Vol. 13, Issue 14 https://doi.org/10.1158/1078-0432.CCR-06-2179	journal	July 2007
Disposition and Metabolic Profiling of [ ¹⁴ C]Cerlapirdine Using Accelerator Mass Spectrometry Tse, Susanna; Leung, Louis; Raje, Sangeeta Drug Metabolism and Disposition, Vol. 42, Issue 12 https://doi.org/10.1124/dmd.114.059675	journal	September 2014
Effective Use of Microdosing and Positron Emission Tomography (PET) Studies on New Drug Discovery and Development Sugiyama, Yuichi Drug Metabolism and Pharmacokinetics, Vol. 24, Issue 2 https://doi.org/10.2133/dmpk.24.127	journal	January 2009
Use of Positron Emission Tomography in Animal Research Cherry, S. R.; Gambhir, S. S. ILAR Journal, Vol. 42, Issue 3 https://doi.org/10.1093/ilar.42.3.219	journal	January 2001
Microdosing studies using accelerated mass spectrometry as exploratory investigational new drug trials Bae, Soo Kyung; Shon, Ji-Hong Archives of Pharmacal Research, Vol. 34, Issue 11 https://doi.org/10.1007/s12272-011-1102-3	journal	November 2011
A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry Graham, Richard A.; Lum, Bert L.; Morrison, Glenn Drug Metabolism and Disposition, Vol. 39, Issue 8 https://doi.org/10.1124/dmd.111.039339	journal	May 2011
Direct measurements of small 14C samples after oxidation in quartz tubes Fahrni, S. M.; Gäggeler, H. W.; Hajdas, I. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 268, Issue 7-8 https://doi.org/10.1016/j.nimb.2009.10.031	journal	April 2010
An interface for the direct coupling of small liquid samples to AMS Ognibene, T. J.; Thomas, A. T.; Daley, P. F. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 361 https://doi.org/10.1016/j.nimb.2015.05.018	journal	October 2015
Systems biology of cisplatin resistance: past, present and future Galluzzi, L.; Vitale, I.; Michels, J. Cell Death & Disease, Vol. 5, Issue 5 https://doi.org/10.1038/cddis.2013.428	journal	May 2014
On-line combustion of samples for AMS and ion source developments at ORAU Bronk Ramsey, C.; Humm, M. J. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 172, Issue 1-4 https://doi.org/10.1016/S0168-583X(00)00116-6	journal	October 2000
In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography Aboagye, Eric O.; Price, Patricia M.; Jones, Terry Drug Discovery Today, Vol. 6, Issue 6 https://doi.org/10.1016/S1359-6446(01)01684-1	journal	March 2001
Prediction of treatment outcome by cisplatin-DNA adduct formation in patients with stage III/IV head and neck squamous cell carcinoma, treated by concurrent cisplatin-radiation (RADPLAT) Hoebers, Frank J. P.; Pluim, Dick; Verheij, Marcel International Journal of Cancer, Vol. 119, Issue 4 https://doi.org/10.1002/ijc.21919	journal	January 2006
Kinetics of Carboplatin−DNA Binding in Genomic DNA and Bladder Cancer Cells As Determined by Accelerator Mass Spectrometry Hah, Sang Soo; Stivers, Kristen M.; de Vere White, Ralph W. Chemical Research in Toxicology, Vol. 19, Issue 5 https://doi.org/10.1021/tx060058c	journal	May 2006
The measurement of cisplatin-DNA adduct levels in testicular cancer patients Reed, Eddie; Ozols, Robert F.; Tarone, Robert Carcinogenesis, Vol. 9, Issue 10 https://doi.org/10.1093/carcin/9.10.1909	journal	January 1988
Platinum-DNA adduct formation in leucocytes of children in relation to pharmacokinetics after cisplatin and carboplatin therapy Peng, B.; Tilby, Mj; English, Mw British Journal of Cancer, Vol. 76, Issue 11 https://doi.org/10.1038/bjc.1997.579	journal	December 1997
Well-Done Meat Intake and the Risk of Breast Cancer Zheng, W.; Gustafson, D. R.; Moore, D. JNCI Journal of the National Cancer Institute, Vol. 90, Issue 22 https://doi.org/10.1093/jnci/90.22.1724	journal	November 1998
Automated Combustion Accelerator Mass Spectrometry for the Analysis of Biomedical Samples in the Low Attomole Range van Duijn, Esther; Sandman, Hugo; Grossouw, Dimitri Analytical Chemistry, Vol. 86, Issue 15 https://doi.org/10.1021/ac5015035	journal	July 2014
Directly Coupled High-Performance Liquid Chromatography–Accelerator Mass Spectrometry Measurement of Chemically Modified Protein and Peptides Thomas, Avi T.; Stewart, Benjamin J.; Ognibene, Ted J. Analytical Chemistry, Vol. 85, Issue 7 https://doi.org/10.1021/ac303609n	journal	March 2013
AFN-1252 in vitro absorption studies and pharmacokinetics following microdosing in healthy subjects Kaplan, Nachum; Garner, Colin; Hafkin, Barry European Journal of Pharmaceutical Sciences, Vol. 50, Issue 3-4 https://doi.org/10.1016/j.ejps.2013.08.019	journal	November 2013
Oxaliplatin-DNA adduct formation in white blood cells of cancer patients Pieck, A. C.; Drescher, A.; Wiesmann, K. G. British Journal of Cancer, Vol. 98, Issue 12 https://doi.org/10.1038/sj.bjc.6604387	journal	May 2008
Retrospective Birth Dating of Cells in Humans Spalding, Kirsty L.; Bhardwaj, Ratan D.; Buchholz, Bruce A. Cell, Vol. 122, Issue 1 https://doi.org/10.1016/j.cell.2005.04.028	journal	July 2005
Human microdosing for the prediction of patient response Henderson, Paul T.; Pan, Chong-xian Bioanalysis, Vol. 2, Issue 3 https://doi.org/10.4155/bio.10.3	journal	March 2010
Practical experience of using human microdosing with AMS analysis to obtain early human drug metabolism and PK data Garner, R. Colin Bioanalysis, Vol. 2, Issue 3 https://doi.org/10.4155/bio.10.6	journal	March 2010
Impact of microdosing clinical study — Why necessary and how useful? Sugiyama, Yuichi; Yamashita, Shinji Advanced Drug Delivery Reviews, Vol. 63, Issue 7 https://doi.org/10.1016/j.addr.2010.09.010	journal	June 2011
Approaches using molecular imaging technology — use of PET in clinical microdose studies Wagner, Claudia C.; Langer, Oliver Advanced Drug Delivery Reviews, Vol. 63, Issue 7 https://doi.org/10.1016/j.addr.2010.09.011	journal	June 2011
Early microdose drug studies in human volunteers can minimise animal testing: Proceedings of a workshop organised by Volunteers in Research and Testing Combes, R. D.; Berridge, T.; Connelly, J. European Journal of Pharmaceutical Sciences, Vol. 19, Issue 1 https://doi.org/10.1016/S0928-0987(03)00040-X	journal	May 2003
Human in Vivo Pharmacokinetics of [ ¹⁴ C]Dibenzo[ def,p ]chrysene by Accelerator Mass Spectrometry Following Oral Microdosing Madeen, Erin; Corley, Richard A.; Crowell, Susan Chemical Research in Toxicology, Vol. 28, Issue 1 https://doi.org/10.1021/tx5003996	journal	December 2014
Emerging concepts on drug resistance in bladder cancer: Implications for future strategies Massari, Francesco; Santoni, Matteo; Ciccarese, Chiara Critical Reviews in Oncology/Hematology, Vol. 96, Issue 1 https://doi.org/10.1016/j.critrevonc.2015.05.005	journal	October 2015
Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs Lappin, G.; Kuhnz, W.; Jochemsen, R. Clinical Pharmacology & Therapeutics, Vol. 80, Issue 3 https://doi.org/10.1016/j.clpt.2006.05.008	journal	September 2006
The use of isotopes in the determination of absolute bioavailability of drugs in humans Lappin, Graham; Rowland, Malcolm; Garner, R. Colin Expert Opinion on Drug Metabolism & Toxicology, Vol. 2, Issue 3 https://doi.org/10.1517/17425255.2.3.419	journal	May 2006
Intrinsic Erythrocyte Labeling and Attomole Pharmacokinetic Tracing of14C-Labeled Folic Acid with Accelerator Mass Spectrometry Buchholz, Bruce A.; Arjomand, Ali; Dueker, Stephen R. Analytical Biochemistry, Vol. 269, Issue 2 https://doi.org/10.1006/abio.1999.4041	journal	May 1999
Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice Cai, Hong; Scott, Edwina; Kholghi, Abeer Science Translational Medicine, Vol. 7, Issue 298 https://doi.org/10.1126/scitranslmed.aaa7619	journal	July 2015
Gemcitabine Causes Minimal Modulation of Carboplatin-DNA Monoadduct Formation and Repair in Bladder Cancer Cells Wang, Sisi; Zhang, Hongyong; Malfatti, Michael Chemical Research in Toxicology, Vol. 23, Issue 11 https://doi.org/10.1021/tx1003547	journal	November 2010
Pediatric Microdose Study of [14C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept Mooij, Miriam G.; van Duijn, Esther; Knibbe, Catherijne A. J. Clinical Pharmacokinetics, Vol. 53, Issue 11 https://doi.org/10.1007/s40262-014-0176-8	journal	September 2014
A Gas Ion Source for Radiocarbon Measurements at 200 kV Ruff, M.; Wacker, L.; Gäggeler, H. W. Radiocarbon, Vol. 49, Issue 2 https://doi.org/10.1017/S0033822200042235	journal	January 2007
A High-Throughput Method for the Conversion of CO ₂ Obtained from Biochemical Samples to Graphite in Septa-Sealed Vials for Quantification of ¹⁴ C via Accelerator Mass Spectrometry Ognibene, Ted J.; Bench, Graham; Vogel, John S. Analytical Chemistry, Vol. 75, Issue 9 https://doi.org/10.1021/ac026334j	journal	May 2003
Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin Egner, P. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 523-524 https://doi.org/10.1016/S0027-5107(02)00337-8	journal	March 2003
Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses Turteltaub, Kenneth W.; Dingley, Karen H.; Curtis, Kellie D. Cancer Letters, Vol. 143, Issue 2 https://doi.org/10.1016/S0304-3835(99)00116-0	journal	September 1999
Cellular processing of platinum anticancer drugs Wang, Dong; Lippard, Stephen J. Nature Reviews Drug Discovery, Vol. 4, Issue 4 https://doi.org/10.1038/nrd1691	journal	March 2005
Molecular Dissection of Induced Platinum Resistance through Functional and Gene Expression Analysis in a Cell Culture Model of Bladder Cancer Wang, Sisi; Zhang, Hongyong; Scharadin, Tiffany M. PLOS ONE, Vol. 11, Issue 1 https://doi.org/10.1371/journal.pone.0146256	journal	January 2016
DNA-adduct levels as a predictor of outcome for NSCLC patients receiving daily cisplatin and radiotherapy van de Vaart, Paul J. M.; Belderbos, Jose; de Jong, Daphne International Journal of Cancer, Vol. 89, Issue 2 https://doi.org/10.1002/(SICI)1097-0215(20000320)89:2<160::AID-IJC10>3.0.CO;2-J	journal	March 2000
Platinum—DNA damage in leukocyte DNA of patients receiving carboplatin and cisplatin chemotherapy, measured by atomic absorption spectrometry Parker, Ricardo J.; Gill, Indrani; Tarone, Robert Carcinogenesis, Vol. 12, Issue 7 https://doi.org/10.1093/carcin/12.7.1253	journal	January 1991
A microdosing approach for characterizing formation and repair of carboplatin-DNA monoadducts and chemoresistance Henderson, Paul T.; Li, Tao; He, Miaoling International Journal of Cancer, Vol. 129, Issue 6 https://doi.org/10.1002/ijc.25814	journal	March 2011
Bioanalytical Applications of Accelerator Mass Spectrometry for Pharmaceutical Research Turteltaub, Kenneth; Vogel, John Current Pharmaceutical Design, Vol. 6, Issue 10 https://doi.org/10.2174/1381612003400047	journal	July 2000
Platinum-based drugs: past, present and future Dilruba, Shahana; Kalayda, Ganna V. Cancer Chemotherapy and Pharmacology, Vol. 77, Issue 6 https://doi.org/10.1007/s00280-016-2976-z	journal	February 2016
Observational infant exploratory [ ¹⁴ C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis : Paediatric paracetamol microdose/therapeutic exploratory PK study Garner, Colin R.; Park, Kevin B.; French, Neil S. British Journal of Clinical Pharmacology, Vol. 80, Issue 1 https://doi.org/10.1111/bcp.12597	journal	June 2015
Accelerator mass spectrometry in the biomedical sciences: applications in low-exposure biomedical and environmental dosimetry Felton, J. S.; Turteltaub, K. W.; Vogel, J. S. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 52, Issue 3-4 https://doi.org/10.1016/0168-583X(90)90469-B	journal	December 1990
Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers Lappin, Graham; Shishikura, Yoko; Jochemsen, Roeline European Journal of Pharmaceutical Sciences, Vol. 43, Issue 3 https://doi.org/10.1016/j.ejps.2011.04.009	journal	June 2011
Use of Microdosing and Accelerator Mass Spectrometry To Evaluate the Pharmacokinetic Linearity of a Novel Tricyclic GyrB/ParE Inhibitor in Rats Malfatti, Michael A.; Lao, Victoria; Ramos, Courtney L. Antimicrobial Agents and Chemotherapy, Vol. 58, Issue 11 https://doi.org/10.1128/AAC.03300-14	journal	August 2014
Ultrahigh Efficiency Moving Wire Combustion Interface for Online Coupling of High-Performance Liquid Chromatography (HPLC) Thomas, Avi T.; Ognibene, Ted; Daley, Paul Analytical Chemistry, Vol. 83, Issue 24 https://doi.org/10.1021/ac202013s	journal	December 2011
Determining the Pharmacokinetics and Long-Term Biodistribution of SiO ₂ Nanoparticles In Vivo Using Accelerator Mass Spectrometry Malfatti, Michael A.; Palko, Heather A.; Kuhn, Edward A. Nano Letters, Vol. 12, Issue 11 https://doi.org/10.1021/nl302412f	journal	October 2012
Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined by in Vivo Thymidine Analog Incorporation and Radiocarbon Dating Perl, S.; Kushner, J. A.; Buchholz, B. A. The Journal of Clinical Endocrinology & Metabolism, Vol. 95, Issue 10 https://doi.org/10.1210/jc.2010-0932	journal	October 2010
Personalized medicine for targeted and platinum-based chemotherapy of lung and bladder cancer Cimino, George D.; Pan, Chong-xian; Henderson, Paul T. Bioanalysis, Vol. 5, Issue 3 https://doi.org/10.4155/bio.12.325	journal	February 2013
Platinum-DNA adducts assayed in leukocytes of patients with germ cell tumors measured by atomic absorbance spectrometry and enzyme-linked immunosorbent assay Motzer, Robert J.; Reed, Eddie; Perera, Frederica Cancer, Vol. 73, Issue 11 https://doi.org/10.1002/1097-0142(19940601)73:11<2843::AID-CNCR2820731130>3.0.CO;2-D	journal	June 1994
Effects of Chlorophyll and Chlorophyllin on Low-Dose Aflatoxin B ₁ Pharmacokinetics in Human Volunteers Jubert, Carole; Mata, John; Bench, Graham Cancer Prevention Research, Vol. 2, Issue 12 https://doi.org/10.1158/1940-6207.CAPR-09-0099	journal	December 2009
A gas ion source for radiocarbon measurement at SUERC Xu, Sheng; Dougans, Andrew; Freeman, Stewart P. H. T. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 259, Issue 1 https://doi.org/10.1016/j.nimb.2007.01.311	journal	June 2007
Evaluation of Microdosing Strategies for Studies in Preclinical drug Development: Demonstration of Linear Pharmacokinetics in dogs of a Nucleoside Analog over a 50-Fold dose Range Sandhu, Punam; Vogel, John S.; Rose, Mark J. Drug Metabolism and Disposition, Vol. 32, Issue 11 https://doi.org/10.1124/dmd.104.000422	journal	July 2004
The Dynamics of Folic Acid Metabolism in an Adult Given a Small Tracer Dose of ¹⁴C-Folic Acid Clifford, Andrew J.; Arjomand, Ali; Dueker, Stephen R. Mathematical Modeling in Experimental Nutrition, p. 239-251 https://doi.org/10.1007/978-1-4899-1959-5_15	book	January 1998
Detection of 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP)–DNA adducts in human pancreatic tissues Zhu, J.; Rashid, A.; Cleary, K. Biomarkers, Vol. 11, Issue 4 https://doi.org/10.1080/13547500600667911	journal	January 2006
A Combined Accelerator Mass Spectrometry-Positron Emission Tomography Human Microdose Study with 14C- and 11C-Labelled Verapamil Wagner, Claudia C.; Simpson, Marie; Zeitlinger, Markus Clinical Pharmacokinetics, Vol. 50, Issue 2 https://doi.org/10.2165/11537250-000000000-00000	journal	January 2011
The debate is over: accelerator MS provides the route to better drug-development paradigms/protocols Smith, Dennis A. Bioanalysis, Vol. 3, Issue 4 https://doi.org/10.4155/bio.11.9	journal	February 2011
Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans Malfatti, Michael A.; Kuhn, Edward A.; Turteltaub, Kenneth W. Chemical Research in Toxicology, Vol. 29, Issue 3 https://doi.org/10.1021/acs.chemrestox.5b00495	journal	March 2016
Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled 14C-cobalamin Carkeet, C.; Dueker, S. R.; Lango, J. Proceedings of the National Academy of Sciences, Vol. 103, Issue 15 https://doi.org/10.1073/pnas.0601251103	journal	April 2006
Cisplatin in cancer therapy: Molecular mechanisms of action Dasari, Shaloam; Bernard Tchounwou, Paul European Journal of Pharmacology, Vol. 740 https://doi.org/10.1016/j.ejphar.2014.07.025	journal	October 2014
Chlorophyllin Chemoprevention in Trout Initiated by Aflatoxin B1 Bath Treatment: An Evaluation of Reduced Bioavailability vs. Target Organ Protective Mechanisms Breinholt, Vibeke; Arbogast, Dan; Loveland, Pat Toxicology and Applied Pharmacology, Vol. 158, Issue 2 https://doi.org/10.1006/taap.1999.8696	journal	July 1999
Tissue Platinum Concentration and Tumor Response in Non–Small-Cell Lung Cancer Kim, Eric S.; Lee, J. Jack; He, Guangan Journal of Clinical Oncology, Vol. 30, Issue 27 https://doi.org/10.1200/JCO.2011.40.8120	journal	September 2012
Relationship between the exposure to cisplatin, DNA-adduct formation in leucocytes and tumour response in patients with solid tumours Schellens, Jhm; Ma, J.; Planting, ASTh British Journal of Cancer, Vol. 73, Issue 12 https://doi.org/10.1038/bjc.1996.296	journal	June 1996
Human mass balance study of TAS-102 using 14C analyzed by accelerator mass spectrometry Lee, James J.; Seraj, Jabed; Yoshida, Kenichiro Cancer Chemotherapy and Pharmacology, Vol. 77, Issue 3 https://doi.org/10.1007/s00280-016-2965-2	journal	January 2016
Cisplatin versus carboplatin: comparative review of therapeutic management in solid malignancies Ho, Gwo Yaw; Woodward, Natasha; Coward, Jermaine I. G. Critical Reviews in Oncology/Hematology, Vol. 102 https://doi.org/10.1016/j.critrevonc.2016.03.014	journal	June 2016
Applications of accelerator MS in pediatric drug evaluation Vuong, Lt; Blood, Ab; Vogel, Js Bioanalysis, Vol. 4, Issue 15 https://doi.org/10.4155/bio.12.173	journal	August 2012
Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5- f ]qiiinoline (IQ) to rat liver DNA Dashwood, Roderick H. Carcinogenesis, Vol. 13, Issue 1 https://doi.org/10.1093/carcin/13.1.113	journal	January 1992
Rapid Production of Graphite Without Contamination for Biomedical AMS Vogel, John S. Radiocarbon, Vol. 34, Issue 3 https://doi.org/10.1017/S0033822200063529	journal	January 1992
HPLC−Accelerator MS Measurement of Atrazine Metabolites in Human Urine after Dermal Exposure Buchholz, Bruce A.; Fultz, Esther; Haack, Kurt W. Analytical Chemistry, Vol. 71, Issue 16 https://doi.org/10.1021/ac990152g	journal	August 1999
Long-term kinetic study of β-carotene, using accelerator mass spectrometry in an adult volunteer Dueker, Stephen R.; Lin, Yumei; Buchholz, Bruce A. Journal of Lipid Research, Vol. 41, Issue 11 https://doi.org/10.1016/S0022-2275(20)31972-6	journal	November 2000

Cited By (2)

Synthesis of carbon-14-labelled peptides Dell'isola, Antonio; Brown, Rodney T.; Jones, Stuart Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 62, Issue 11 https://doi.org/10.1002/jlcr.3777	journal	August 2019
Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies Kratochwil, Nicole A.; Dueker, Stephen R.; Muri, Dieter PLOS ONE, Vol. 13, Issue 10 https://doi.org/10.1371/journal.pone.0205435	journal	October 2018

Similar Records

Evaluation Of Microdosing Strategies For Studies In Preclinical Drug Development: Demonstration Of Linear Pharmacokinetics In Dogs Of A Nucleoside Analogue Over A 50-Fold Dose Range

Journal Article · Thu Apr 22 00:00:00 EDT 2004 · Drug Metabolism and Disposition · OSTI ID:1367988

Sandhu, P; Vogel, J S; Rose, M J; +8 more

The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity

Journal Article · Sat May 15 00:00:00 EDT 2010 · Toxicology and Applied Pharmacology · OSTI ID:1367988

Amacher, David E

Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science

Journal Article · Thu May 09 00:00:00 EDT 2019 · Toxics · OSTI ID:1367988

Malfatti, Michael A.; Buchholz, Bruce A.; Enright, Heather A.; +12 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES

Title: Use of Accelerator Mass Spectrometry in Human Health and Molecular Toxicology

Citation Formats

References (82)

Cited By (2)

Similar Records

Related Subjects