Receptor signaling clusters in the immune synapse

Dustin, Michael L.; Groves, Jay T.

doi:10.1146/annurev-biophys-042910-155238

Title: Receptor signaling clusters in the immune synapse (in eng)

Journal Article · Thu Feb 23 00:00:00 EST 2012 · Annual Review of Biophysics

DOI:https://doi.org/10.1146/annurev-biophys-042910-155238· OSTI ID:1363640

Dustin, Michael L. ^[1]; Groves, Jay T. ^[2]

New York Univ. School of Medicine, New York, NY (United States)
Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Signaling processes between various immune cells involve large-scale spatial reorganization of receptors and signaling molecules within the cell-cell junction. These structures, now collectively referred to as immune synapses, interleave physical and mechanical processes with the cascades of chemical reactions that constitute signal transduction systems. Molecular level clustering, spatial exclusion, and long-range directed transport are all emerging as key regulatory mechanisms. The study of these processes is drawing researchers from physical sciences to join the effort and represents a rapidly growing branch of biophysical chemistry. Furthermore, recent advances in physical and quantitative analyses of signaling within the immune synapses are reviewed here.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: Physical Biosciences Division; USDOE

OSTI ID:: 1363640

Report Number(s):: LBNL-1004332; ir:1004332

Journal Information:: Annual Review of Biophysics, Vol. 41, Issue 1; ISSN 1936-122X

Publisher:: Annual ReviewsCopyright Statement

Country of Publication:: United States

Language:: eng

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Cited by: 157 works

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CD56 expression in breast cancer induces sensitivity to natural killer-mediated cytotoxicity by enhancing the formation of cytotoxic immunological synapse Taouk, Ghina; Hussein, Ola; Zekak, Moussa Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-45377-8	journal	June 2019
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