Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung

Dautel, Sydney E.; Kyle, Jennifer E.; Clair, Geremy; Sontag, Ryan L.; Weitz, Karl K.; Shukla, Anil K.; Nguyen, Son N.; Kim, Young -Mo; Zink, Erika M.; Luders, Teresa; Frevert, Charles W.; Gharib, Sina A.; Laskin, Julia; Carson, James P.; Metz, Thomas O.; Corley, Richard A.; Ansong, Charles

doi:10.1038/srep40555

Title: Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung

Journal Article · Wed Feb 01 00:00:00 EST 2017 · Scientific Reports

DOI:https://doi.org/10.1038/srep40555· OSTI ID:1347837

Dautel, Sydney E. ^[1]; Kyle, Jennifer E. ^[1]; Clair, Geremy ^[1]; Sontag, Ryan L. ^[1]; Weitz, Karl K. ^[1]; Shukla, Anil K. ^[1]; Nguyen, Son N. ^[1]; Kim, Young -Mo ^[1]; Zink, Erika M. ^[1]; Luders, Teresa ^[1]; Frevert, Charles W. ^[2]; Gharib, Sina A. ^[2]; Laskin, Julia ^[1]; Carson, James P. ^[3]; Metz, Thomas O. ^[1]; Corley, Richard A. ^[1]; Ansong, Charles ^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Univ. of Washington, Seattle, WA (United States)
Univ. of Texas, Austin, TX (United States)

Lung immaturity is a major cause of morbidity and mortality in premature infants. Understanding the molecular mechanisms driving normal lung development could provide insights on how to ameliorate disrupted development. While transcriptomic and proteomic analyses of normal lung development have been previously reported, characterization of changes in the lipidome is lacking. Lipids play significant roles in the lung, such as dipalmitoylcholine in pulmonary surfactant; however, many of the roles of specific lipid species in normal lung development, as well as in disease states, are not well defined. In this study, we used liquid chromatography-mass spectrometry (LC-MS/MS) to investigate the murine lipidome during normal postnatal lung development. Lipidomics analysis of lungs from post-natal day 7, day 14 and 6-8 week mice (adult) identified 928 unique lipids across 21 lipid subclasses, with dramatic alterations in the lipidome across developmental stages. Our data confirmed previously recognized aspects of post-natal lung development and revealed several insights, including in sphingolipid-mediated apoptosis, inflammation and energy storage/usage. Complementary proteomics, metabolomics and chemical imaging corroborated these observations. Finally, this multi-omic view provides a unique resource and deeper insight into normal pulmonary development.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1347837

Report Number(s):: PNNL-SA-121148; 49133; 48632; 453040220

Journal Information:: Scientific Reports, Vol. 7; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 57 works

Citation information provided by
Web of Science

References (67)

Silencing of membrane-associated sialidase Neu3 diminishes apoptosis resistance and triggers megakaryocytic differentiation of chronic myeloid leukemic cells K562 through the increase of ganglioside GM3 Tringali, C.; Lupo, B.; Cirillo, F. Cell Death & Differentiation, Vol. 16, Issue 1 https://doi.org/10.1038/cdd.2008.141	journal	September 2008
Reconstructing dynamic microRNA-regulated interaction networks Schulz, M. H.; Pandit, K. V.; Lino Cardenas, C. L. Proceedings of the National Academy of Sciences, Vol. 110, Issue 39 https://doi.org/10.1073/pnas.1303236110	journal	August 2013
A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr-/- mice Freedman, S. D.; Katz, M. H.; Parker, E. M. Proceedings of the National Academy of Sciences, Vol. 96, Issue 24 https://doi.org/10.1073/pnas.96.24.13995	journal	November 1999
Bioactive Lysophosphatidylcholine 16:0 and 18:0 Are Elevated in Lungs of Asthmatic Subjects Yoder, Mark; Zhuge, Yan; Yuan, Yang Allergy, Asthma & Immunology Research, Vol. 6, Issue 1 https://doi.org/10.4168/aair.2014.6.1.61	journal	January 2014
Chain length-specific properties of ceramides Grösch, Sabine; Schiffmann, Susanne; Geisslinger, Gerd Progress in Lipid Research, Vol. 51, Issue 1 https://doi.org/10.1016/j.plipres.2011.11.001	journal	January 2012
Medium-Chain Triglycerides in Infant Formulas and their Relation to Plasma Ketone Body Concentrations Wu, Paul Y. K.; Edmond, John; Auestad, Nancy Pediatric Research, Vol. 20, Issue 4 https://doi.org/10.1203/00006450-198604000-00016	journal	April 1986
Stimulated Bronchial Epithelial Cells Release Bioactive Lysophosphatidylcholine 16:0, 18:0, and 18:1 Zhuge, Yan; Yuan, Yang; van Breemen, Richard Allergy, Asthma & Immunology Research, Vol. 6, Issue 1 https://doi.org/10.4168/aair.2014.6.1.66	journal	January 2014
Medium-chain triglycerides Marten, Berit; Pfeuffer, Maria; Schrezenmeir, Jürgen International Dairy Journal, Vol. 16, Issue 11 https://doi.org/10.1016/j.idairyj.2006.06.015	journal	November 2006
Resolvins and protectins: mediating solutions to inflammation: Chemical mediators of inflammation resolution Kohli, Payal; Levy, Bruce D. British Journal of Pharmacology, Vol. 158, Issue 4 https://doi.org/10.1111/j.1476-5381.2009.00290.x	journal	July 2009
Update of the LIPID MAPS comprehensive classification system for lipids Fahy, Eoin; Subramaniam, Shankar; Murphy, Robert C. Journal of Lipid Research, Vol. 50, Issue Supplement https://doi.org/10.1194/jlr.R800095-JLR200	journal	December 2008
Deep and Highly Sensitive Proteome Coverage by LC-MS/MS Without Prefractionation Thakur, Suman S.; Geiger, Tamar; Chatterjee, Bhaswati Molecular & Cellular Proteomics, Vol. 10, Issue 8 https://doi.org/10.1074/mcp.M110.003699	journal	May 2011
Regulation of sphingosine 1‐phosphate‐induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P ₁ receptor, PI3 kinase, Tiam1/Rac1, and α‐actinin Singleton, Patrick A.; Dudek, Steven M.; Chiang, Eddie T. The FASEB Journal, Vol. 19, Issue 12 https://doi.org/10.1096/fj.05-3928com	journal	July 2005
Sphingosine-1–Phosphate, FTY720, and Sphingosine-1–Phosphate Receptors in the Pathobiology of Acute Lung Injury Natarajan, Viswanathan; Dudek, Steven M.; Jacobson, Jeffrey R. American Journal of Respiratory Cell and Molecular Biology, Vol. 49, Issue 1 https://doi.org/10.1165/rcmb.2012-0411tr	journal	July 2013
Lysophosphatidylcholine Enhances Superoxide Anions Production via Endothelial NADH/NADPH Oxidase Takeshita, Saori; Inoue, Nobutaka; Gao, Dayaun Journal of Atherosclerosis and Thrombosis, Vol. 7, Issue 4 https://doi.org/10.5551/jat1994.7.238	journal	January 2000
Functions of plasmalogen lipids in health and disease Braverman, Nancy E.; Moser, Ann B. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1822, Issue 9 https://doi.org/10.1016/j.bbadis.2012.05.008	journal	September 2012
Using machine learning to identify disease-relevant regulatory RNAs Ohler, Uwe Proceedings of the National Academy of Sciences, Vol. 110, Issue 39 https://doi.org/10.1073/pnas.1315199110	journal	September 2013
Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis Chipuk, Jerry E.; McStay, Gavin P.; Bharti, Archana Cell, Vol. 148, Issue 5 https://doi.org/10.1016/j.cell.2012.01.038	journal	March 2012
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators Serhan, Charles N.; Chiang, Nan; Van Dyke, Thomas E. Nature Reviews Immunology, Vol. 8, Issue 5 https://doi.org/10.1038/nri2294	journal	May 2008
Automated Platform for High-Resolution Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry Lanekoff, Ingela; Heath, Brandi S.; Liyu, Andrey Analytical Chemistry, Vol. 84, Issue 19 https://doi.org/10.1021/ac301909a	journal	September 2012
The role of lipids in pulmonary surfactant Veldhuizen, Ruud; Nag, Kaushik; Orgeig, Sandra Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1408, Issue 2-3 https://doi.org/10.1016/S0925-4439(98)00061-1	journal	November 1998
Synthesis and secretion of plasmalogens by type-II pneumocytes Rüstow, B.; Kolleck, I.; Guthmann, F. Biochemical Journal, Vol. 302, Issue 3 https://doi.org/10.1042/bj3020665	journal	September 1994
Integrated Omics Analysis of Pathogenic Host Responses during Pandemic H1N1 Influenza Virus Infection: The Crucial Role of Lipid Metabolism Tisoncik-Go, Jennifer; Gasper, David J.; Kyle, Jennifer E. Cell Host & Microbe, Vol. 19, Issue 2 https://doi.org/10.1016/j.chom.2016.01.002	journal	February 2016
Systems biology approaches to identify developmental bases for lung diseases Bhattacharya, Soumyaroop; Mariani, Thomas J. Pediatric Research, Vol. 73, Issue 2-4 https://doi.org/10.1038/pr.2013.7	journal	January 2013
Sphingosine 1-Phosphate-induced Cell Proliferation, Survival, and Related Signaling Events Mediated by G Protein-coupled Receptors Edg3 and Edg5 An, Songzhu; Zheng, Yuhua; Bleu, Thieu Journal of Biological Chemistry, Vol. 275, Issue 1 https://doi.org/10.1074/jbc.275.1.288	journal	January 2000
A comparison of the molecular species compositions of mammalian lung surfactant phospholipids Postle, Anthony D.; Heeley, Emma L.; Wilton, David C. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Vol. 129, Issue 1 https://doi.org/10.1016/S1095-6433(01)00306-3	journal	May 2001
Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation Shimizu, Takao Annual Review of Pharmacology and Toxicology, Vol. 49, Issue 1 https://doi.org/10.1146/annurev.pharmtox.011008.145616	journal	February 2009
Apoptotic Sphingolipid Signaling by Ceramides in Lung Endothelial Cells Medler, Terry R.; Petrusca, Daniela N.; Lee, Patty J. American Journal of Respiratory Cell and Molecular Biology, Vol. 38, Issue 6 https://doi.org/10.1165/rcmb.2007-0274oc	journal	June 2008
Sphingolipids in Lung Growth and Repair Tibboel, Jeroen; Reiss, Irwin; de Jongste, Johan C. Chest, Vol. 145, Issue 1 https://doi.org/10.1378/chest.13-0967	journal	January 2014
Arachidonic acid-selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumor necrosis factor Hayakawa, M.; Ishida, N.; Takeuchi, K. Journal of Biological Chemistry, Vol. 268, Issue 15 https://doi.org/10.1016/s0021-9258(18)82123-8	journal	May 1993
The Lipidome: A New Player in Chronic Obstructive Pulmonary Disease Pathophysiology? Donnelly, Louise E. American Journal of Respiratory and Critical Care Medicine, Vol. 190, Issue 2 https://doi.org/10.1164/rccm.201406-1061ed	journal	July 2014
Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry Cajka, Tomas; Fiehn, Oliver TrAC Trends in Analytical Chemistry, Vol. 61 https://doi.org/10.1016/j.trac.2014.04.017	journal	October 2014
Medium chain fatty acid metabolism and energy expenditure: Obesity treatment implications Papamandjaris, Andrea A.; Macdougall, Diane E.; Jones, Peter J. H. Life Sciences, Vol. 62, Issue 14 https://doi.org/10.1016/s0024-3205(97)01143-0	journal	February 1998
FiehnLib: Mass Spectral and Retention Index Libraries for Metabolomics Based on Quadrupole and Time-of-Flight Gas Chromatography/Mass Spectrometry Kind, Tobias; Wohlgemuth, Gert; Lee, Do Yup Analytical Chemistry, Vol. 81, Issue 24 https://doi.org/10.1021/ac9019522	journal	December 2009
Lysophosphatidylcholine as a possible second messenger synergistic to diacylglycerol and calcium ion for T-lymphocyte activation Asaoka, Yoshinori; Oka, Masahiro; Yoshida, Kimihisa Biochemical and Biophysical Research Communications, Vol. 178, Issue 3 https://doi.org/10.1016/0006-291x(91)91046-f	journal	August 1991
Upregulation of endothelial adhesion molecules by lysophosphatidylcholine: Involvement of G protein-coupled receptor GPR4 Zou, Yani; Kim, Chul H.; Chung, Jae H. FEBS Journal, Vol. 274, Issue 10 https://doi.org/10.1111/j.1742-4658.2007.05792.x	journal	April 2007
Omega-3 Fatty Acids and Inflammatory Processes Calder, Philip C. Nutrients, Vol. 2, Issue 3 https://doi.org/10.3390/nu2030355	journal	March 2010
Lysophosphatidylcholine perpetuates macrophage polarization toward classically activated phenotype in inflammation Qin, Xiaofei; Qiu, Chunguang; Zhao, Luosha Cellular Immunology, Vol. 289, Issue 1-2 https://doi.org/10.1016/j.cellimm.2014.04.010	journal	May 2014
Developmental alveolarization of the mouse lung Mund, Sonja I.; Stampanoni, Marco; Schittny, Johannes C. Developmental Dynamics, Vol. 237, Issue 8 https://doi.org/10.1002/dvdy.21633	journal	August 2008
The protective role of plasmalogens in iron-induced lipid peroxidation Sindelar, Pavel J.; Guan, Zhizhong; Dallner, Gustav Free Radical Biology and Medicine, Vol. 26, Issue 3-4 https://doi.org/10.1016/s0891-5849(98)00221-4	journal	February 1999
MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data Pluskal, Tomáš; Castillo, Sandra; Villar-Briones, Alejandro BMC Bioinformatics, Vol. 11, Issue 1 https://doi.org/10.1186/1471-2105-11-395	journal	July 2010
DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation Duvall, Melody G.; Levy, Bruce D. European Journal of Pharmacology, Vol. 785 https://doi.org/10.1016/j.ejphar.2015.11.001	journal	August 2016
A reversed-phase capillary ultra-performance liquid chromatography–mass spectrometry (UPLC-MS) method for comprehensive top-down/bottom-up lipid profiling Gao, Xiaoli; Zhang, Qibin; Meng, Da Analytical and Bioanalytical Chemistry, Vol. 402, Issue 9 https://doi.org/10.1007/s00216-012-5773-5	journal	February 2012
Sphingolipids in the Lungs Uhlig, Stefan; Gulbins, Erich American Journal of Respiratory and Critical Care Medicine, Vol. 178, Issue 11 https://doi.org/10.1164/rccm.200804-595so	journal	December 2008
Sphingolipids as cell fate regulators in lung development and disease Lee, Joyce; Yeganeh, Behzad; Ermini, Leonardo Apoptosis, Vol. 20, Issue 5 https://doi.org/10.1007/s10495-015-1112-6	journal	March 2015
Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response Spassieva, Stefka D.; Mullen, Thomas D.; Townsend, Danyelle M. Biochemical Journal, Vol. 424, Issue 2 https://doi.org/10.1042/BJ20090699	journal	November 2009
Diel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms Kim, Young-Mo; Nowack, Shane; Olsen, Millie T. Frontiers in Microbiology, Vol. 6 https://doi.org/10.3389/fmicb.2015.00209	journal	April 2015
MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses Nakayasu, Ernesto S.; Nicora, Carrie D.; Sims, Amy C. mSystems, Vol. 1, Issue 3 https://doi.org/10.1128/mSystems.00043-16	journal	May 2016
Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics Diamond, Deborah L.; Syder, Andrew J.; Jacobs, Jon M. PLoS Pathogens, Vol. 6, Issue 1 https://doi.org/10.1371/journal.ppat.1000719	journal	January 2010
Activities of enzymes of ketone body metabolism in liver and muscle tissues of suckling rabbits Beis, Androniki Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, Vol. 81, Issue 1 https://doi.org/10.1016/0305-0491(85)90191-9	journal	January 1985
Surfactant Lipidomics in Healthy Children and Childhood Interstitial Lung Disease Griese, Matthias; Kirmeier, Hannah G.; Liebisch, Gerhard PLOS ONE, Vol. 10, Issue 2 https://doi.org/10.1371/journal.pone.0117985	journal	February 2015
Injurious effects of lysophosphatidylcholine on barrier properties of alveolar epithelium Niewoehner, D. E.; Rice, K.; Sinha, A. A. Journal of Applied Physiology, Vol. 63, Issue 5 https://doi.org/10.1152/jappl.1987.63.5.1979	journal	November 1987
Lung Fibroblasts Undergo Apoptosis Following Alveolarization Bruce, Margaret C.; Honaker, Catherine E.; Cross, Richard J. American Journal of Respiratory Cell and Molecular Biology, Vol. 20, Issue 2 https://doi.org/10.1165/ajrcmb.20.2.3150	journal	February 1999
Lysophosphatidylcholine induces the production of IL-1β by human monocytes Liu-Wu, Yani; Hurt-Camejo, Eva; Wiklund, Olov Atherosclerosis, Vol. 137, Issue 2 https://doi.org/10.1016/s0021-9150(97)00295-5	journal	April 1998
MASIC: A software program for fast quantitation and flexible visualization of chromatographic profiles from detected LC–MS(/MS) features Monroe, Matthew E.; Shaw, Jason L.; Daly, Don S. Computational Biology and Chemistry, Vol. 32, Issue 3 https://doi.org/10.1016/j.compbiolchem.2008.02.006	journal	June 2008
Ontogeny of Apoptosis during Lung Development Kresch, Mitchell J.; Christian, Constance; Wu, Fengying Pediatric Research, Vol. 43, Issue 3 https://doi.org/10.1203/00006450-199803000-00020	journal	March 1998
Causes and Timing of Death in Extremely Premature Infants from 2000 through 2011 Patel, Ravi M.; Kandefer, Sarah; Walsh, Michele C. New England Journal of Medicine, Vol. 372, Issue 4 https://doi.org/10.1056/nejmoa1403489	journal	January 2015
Simultaneous Metabolite, Protein, Lipid Extraction (SIMPLEX): A Combinatorial Multimolecular Omics Approach for Systems Biology Coman, Cristina; Solari, Fiorella Andrea; Hentschel, Andreas Molecular & Cellular Proteomics, Vol. 15, Issue 4 https://doi.org/10.1074/mcp.M115.053702	journal	January 2016
A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language Herzog, Ronny; Schwudke, Dominik; Schuhmann, Kai Genome Biology, Vol. 12, Issue 1 https://doi.org/10.1186/gb-2011-12-1-r8	journal	January 2011
Preterm delivery Slattery, Michael M.; Morrison, John J. The Lancet, Vol. 360, Issue 9344 https://doi.org/10.1016/S0140-6736(02)11476-0	journal	November 2002
A comprehensive classification system for lipids Fahy, Eoin; Subramaniam, Shankar; Brown, H. Alex European Journal of Lipid Science and Technology, Vol. 107, Issue 5 https://doi.org/10.1002/ejlt.200405001	journal	May 2005
Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells Wang, Yuexi; Yang, Feng; Gritsenko, Marina A. PROTEOMICS, Vol. 11, Issue 10 https://doi.org/10.1002/pmic.201000722	journal	April 2011
Born Too Soon: Preterm birth matters Howson, Christopher P.; Kinney, Mary V.; McDougall, Lori Reproductive Health, Vol. 10, Issue S1 https://doi.org/10.1186/1742-4755-10-s1-s1	journal	November 2013
MS-GF+ makes progress towards a universal database search tool for proteomics Kim, Sangtae; Pevzner, Pavel A. Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms6277	journal	October 2014
Experimental neonatal respiratory failure induced by lysophosphatidylcholine: effect of surfactant treatment Grossmann, Gertie; Tashiro, Katsumi; Kobayashi, Tsutomu Journal of Applied Physiology, Vol. 86, Issue 2 https://doi.org/10.1152/jappl.1999.86.2.633	journal	February 1999
Visualising associations between paired ‘omics’ data sets González, Ignacio; Cao, Kim-Anh Lê; Davis, Melissa J. BioData Mining, Vol. 5, Issue 1 https://doi.org/10.1186/1756-0381-5-19	journal	November 2012
Fibroblasts Expressing PDGF-Receptor-Alpha Diminish During Alveolar Septal Thinning in Mice McGowan, Stephen E.; McCoy, Diann M. Pediatric Research, Vol. 70, Issue 1 https://doi.org/10.1203/pdr.0b013e31821cfb5a	journal	July 2011
A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues Folch, Jordi; Lees, M.; Stanley, G. H. Sloane Journal of Biological Chemistry, Vol. 226, Issue 1 https://doi.org/10.1016/S0021-9258(18)64849-5	journal	May 1957

Cited By (15)

Candida auris : multi-omics signature of an emerging and multidrug-resistant pathogen Zamith-Miranda, Daniel; Heyman, Heino M.; Cleare, Levi G. https://doi.org/10.1101/528232	posted_content	January 2019
A Biostimulant Obtained from the Seaweed Ascophyllum nodosum Protects Arabidopsis thaliana from Severe Oxidative Stress Omidbakhshfard, Mohammad Amin; Sujeeth, Neerakkal; Gupta, Saurabh International Journal of Molecular Sciences, Vol. 21, Issue 2 https://doi.org/10.3390/ijms21020474	journal	January 2020
Cell type-resolved human lung lipidome reveals cellular cooperation in lung function Kyle, Jennifer E.; Clair, Geremy; Bandyopadhyay, Gautam Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-31640-x	journal	September 2018
A Biostimulant Obtained from the Seaweed Ascophyllum nodosum Protects Arabidopsis thaliana from Severe Oxidative Stress Omidbakhshfard, Mohammad Amin; Sujeeth, Neerakkal; Gupta, Saurabh Universität Potsdam https://doi.org/10.25932/publishup-44509	text	January 2020
Quantitative lipidomic analysis of mouse lung during postnatal development by electrospray ionization tandem mass spectrometry Karnati, Srikanth; Garikapati, Vannuruswamy; Liebisch, Gerhard PLOS ONE, Vol. 13, Issue 9 https://doi.org/10.1371/journal.pone.0203464	journal	September 2018
High-resolution atmospheric-pressure MALDI mass spectrometry imaging workflow for lipidomic analysis of late fetal mouse lungs Garikapati, Vannuruswamy; Karnati, Srikanth; Bhandari, Dhaka Ram Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-39452-3	journal	February 2019
A global lipid map defines a network essential for Zika virus replication Leier, Hans C.; Weinstein, Jules B.; Kyle, Jennifer E. https://doi.org/10.1101/2020.01.27.910919	journal	January 2020
Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients Khanova, Elena; Wu, Raymond; Wang, Wen Hepatology, Vol. 67, Issue 5 https://doi.org/10.1002/hep.29645	journal	February 2018
MALDI-TOF Mass Spectrometry Revealed Significant Lipid Variations in Follicular Fluid and Somatic Follicular Cells but Not in Enclosed Oocytes between the Large Dominant and Small Subordinate Follicles in Bovine Ovary Bertevello, Priscila Silvana; Teixeira-Gomes, Ana-Paula; Labas, Valerie International Journal of Molecular Sciences, Vol. 21, Issue 18 https://doi.org/10.3390/ijms21186661	journal	September 2020
Plasma lipidome reveals critical illness and recovery from human Ebola virus disease Kyle, J. E.; Burnum-Johnson, K. E.; Wendler, J. P. Proceedings of the National Academy of Sciences, Vol. 116, Issue 9 https://doi.org/10.1073/pnas.1815356116	journal	February 2019
LungMAP: The Molecular Atlas of Lung Development Program Ardini-Poleske, Maryanne E.; Clark, Robert F.; Ansong, Charles American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 313, Issue 5 https://doi.org/10.1152/ajplung.00139.2017	journal	November 2017
Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia Lignelli, Ettore; Palumbo, Francesco; Myti, Despoina American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 317, Issue 6 https://doi.org/10.1152/ajplung.00369.2019	journal	December 2019
Novel Comprehensive Bioinformatics Approaches to Determine the Molecular Genetic Susceptibility Profile of Moderate and Severe Asthma Zayed, Hatem International Journal of Molecular Sciences, Vol. 21, Issue 11 https://doi.org/10.3390/ijms21114022	journal	June 2020
A multiomics focusing towards the molecular networks of lung development Clair, Geremy American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 317, Issue 5 https://doi.org/10.1152/ajplung.00364.2019	journal	November 2019
The role of the 17q21 genotype in the prevention of early childhood asthma and recurrent wheeze by vitamin D Kelly, Rachel S.; Chawes, Bo L.; Guo, Feng European Respiratory Journal, Vol. 54, Issue 4 https://doi.org/10.1183/13993003.00761-2019	journal	August 2019

Similar Records

Cell type-resolved human lung lipidome reveals cellular cooperation in lung function

Journal Article · Fri Sep 07 00:00:00 EDT 2018 · Scientific Reports · OSTI ID:1347837

Kyle, Jennifer E.; Clair, Geremy; Bandyopadhyay, Gautam; +18 more

Cell type-resolved human lung lipidome reveals cellular cooperation in lung function

Journal Article · Fri Sep 07 00:00:00 EDT 2018 · Scientific Reports · OSTI ID:1347837

Kyle, Jennifer E.; Clair, Geremy; Bandyopadhyay, Gautam; +18 more

MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses

Journal Article · Tue May 03 00:00:00 EDT 2016 · mSystems · OSTI ID:1347837

Nakayasu, Ernesto S.; Nicora, Carrie D.; Sims, Amy C.; +13 more

Related Subjects

60 APPLIED LIFE SCIENCES
59 BASIC BIOLOGICAL SCIENCES
Environmental Molecular Sciences Laboratory
lipidomics
organogenesis

Title: Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung

Citation Formats

References (67)

Cited By (15)

Similar Records

Related Subjects