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Title: An Arabidopsis gene regulatory network for secondary cell wall synthesis

Journal Article · · Nature (London)
DOI:https://doi.org/10.1038/nature14099· OSTI ID:1347111
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  1. Univ. of California, Davis, CA (United States). Dept. of Plant Biology and Genome Center
  2. Univ. of Massachusetts, Amherst, MA (United States). Biology Dept.
  3. Univ. of California, Berkeley, CA (United States). Dept. of Plant and Microbial Biology
  4. Univ. of California, Davis, CA (United States). Dept. of Plant Biology
  5. Univ. of California, Davis, CA (United States). Dept. of Plant Sciences
  6. Univ. of California, Davis, CA (United States). Genome Center and Dept. of Computer Science
  7. Cold Spring Harbor Lab., NY (United States)
  8. Cold Spring Harbor Lab., NY (United States); US Dept. of Agriculture (USDA)., Ithaca, NY (United States)
  9. Univ. of California, San Diego, CA (United States). Section of Cell and Developmental Biology
  10. Univ. of Cambridge (United Kingdom). Theory of Condensed Matter Group
+ Show Author Affiliations

The plant cell wall is an important factor for determining cell shape, function and response to the environment. Secondary cell walls, such as those found in xylem, are composed of cellulose, hemicelluloses and lignin and account for the bulk of plant biomass. The coordination between transcriptional regulation of synthesis for each polymer is complex and vital to cell function. A regulatory hierarchy of developmental switches has been proposed, although the full complement of regulators remains unknown. In this paper, we present a protein–DNA network between Arabidopsis thaliana transcription factors and secondary cell wall metabolic genes with gene expression regulated by a series of feed-forward loops. This model allowed us to develop and validate new hypotheses about secondary wall gene regulation under abiotic stress. Distinct stresses are able to perturb targeted genes to potentially promote functional adaptation. Finally, these interactions will serve as a foundation for understanding the regulation of a complex, integral plant component.

Research Organization:
Univ. of Massachusetts, Amherst, MA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
Grant/Contract Number:
FG02-08ER64700
OSTI ID:
1347111
Journal Information:
Nature (London), Vol. 517, Issue 7536; ISSN 0028-0836
Publisher:
Nature Publishing GroupCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 447 works
Citation information provided by
Web of Science

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