Ecological and genetic barriers differentiate natural populations of Saccharomyces cerevisiae

Clowers, Katie J.; Heilberger, Justin; Piotrowski, Jeff S.; Will, Jessica L.; Gasch, Audrey P.

doi:10.1093/molbev/msv112

Title: Ecological and genetic barriers differentiate natural populations of Saccharomyces cerevisiae

Journal Article · Wed May 06 00:00:00 EDT 2015 · Molecular Biology and Evolution

DOI:https://doi.org/10.1093/molbev/msv112· OSTI ID:1343407

Clowers, Katie J. ^[1]; Heilberger, Justin ^[1]; Piotrowski, Jeff S. ^[2]; Will, Jessica L. ^[3]; Gasch, Audrey P. ^[4]

Univ. of Wisconsin, Madison, WI (United States). Lab. of Genetics
Great Lakes Bioenergy Research Center, Madison, WI (United States)
Univ. of Wisconsin, Madison, WI (United States). Lab. of Genetics; Univ. of Georgia, Athens, GA (United States)
Univ. of Wisconsin, Madison, WI (United States). Lab. of Genetics; Great Lakes Bioenergy Research Center, Madison, WI (United States)

How populations that inhabit the same geographical area become genetically differentiated is not clear. To investigate this, we characterized phenotypic and genetic differences between two populations of Saccharomyces cerevisiae that in some cases inhabit the same environment but show relatively little gene flow. We profiled stress sensitivity in a group of vineyard isolates and a group of oak-soil strains and found several niche-related phenotypes that distinguish the populations. We performed bulk-segregant mapping on two of the distinguishing traits: The vineyard-specific ability to grow in grape juice and oak-specific tolerance to the cell wall damaging drug Congo red. To implicate causal genes, we also performed a chemical genomic screen in the lab-strain deletion collection and identified many important genes that fell under quantitative trait loci peaks. One gene important for growth in grape juice and identified by both the mapping and the screen was SSU1, a sulfite-nitrite pump implicated in wine fermentations. The beneficial allele is generated by a known translocation that we reasoned may also serve as a genetic barrier. We found that the translocation is prevalent in vineyard strains, but absent in oak strains, and presents a postzygotic barrier to spore viability. Furthermore, the translocation was associated with a fitness cost to the rapid growth rate seen in oak-soil strains. Lastly, our results reveal the translocation as a dual-function locus that enforces ecological differentiation while producing a genetic barrier to gene flow in these sympatric populations.

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Research Organization:: Univ. of Wisconsin, Madison, WI (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Inst. of Health (NIH) (United States)

Contributing Organization:: Great Lakes Bioenergy Research Center, Madison, WI (United States)

Grant/Contract Number:: FC02-07ER64494; T32HG002760; T32GM007133-36; T32GM007133-39

OSTI ID:: 1343407

Journal Information:: Molecular Biology and Evolution, Vol. 32, Issue 9; ISSN 0737-4038

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 23 works

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59 BASIC BIOLOGICAL SCIENCES
ecological divergence
environmental stress
genetic incompatibilities
quantitative trait mapping
reproductive isolation
speciation

Title: Ecological and genetic barriers differentiate natural populations of Saccharomyces cerevisiae

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