Tandem mass spectrometry in combination with product ion mobility for the identification of phospholipids

Berry, Karin A. Zemski; Barkley, Robert M.; Berry, Joseph J.; Hankin, Joseph A.; Hoyes, Emmy; Brown, Jeffery M.; Murphy, Robert C.

doi:10.1021/acs.analchem.6b04047

Title: Tandem mass spectrometry in combination with product ion mobility for the identification of phospholipids

Journal Article · Tue Nov 29 00:00:00 EST 2016 · Analytical Chemistry

DOI:https://doi.org/10.1021/acs.analchem.6b04047· OSTI ID:1339606

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^[1]; Berry, Joseph J. ^[2]; Hankin, Joseph A. ^[1]; Hoyes, Emmy ^[3]; Brown, Jeffery M. ^[3];

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Univ. of Colorado, Boulder, CO (United States)
National Renewable Energy Lab. (NREL), Golden, CO (United States)
Waters Corp., Wilmslow (United Kingdom)

Concerted tandem and traveling wave ion mobility mass spectrometry (CTS analysis) is a unique method that results in a four-dimensional data set including nominal precursor ion mass, product ion mobility, accurate mass of product ion, and ion abundance. This nontargeted lipidomics CTS approach was applied in both positive- and negative-ion mode to phospholipids present in human serum, and the data set was used to evaluate the value of product ion mobility in identifying lipids in a complex mixture. As a result, it was determined that the combination of diagnostic product ions and unique collisional cross-section values of product ions is a powerful tool in the structural identification of lipids in a complex biological sample.

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Research Organization:: National Renewable Energy Lab. (NREL), Golden, CO (United States)

Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE)

Grant/Contract Number:: AC36-08GO28308

OSTI ID:: 1339606

Report Number(s):: NREL/JA-5K00-67567

Journal Information:: Analytical Chemistry, Vol. 89, Issue 1; ISSN 0003-2700

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 21 works

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Adding a new separation dimension to MS and LC-MS: What is the utility of ion mobility spectrometry? D'Atri, Valentina; Causon, Tim; Hernandez-Alba, Oscar Journal of Separation Science, Vol. 41, Issue 1 https://doi.org/10.1002/jssc.201700919	journal	November 2017
Phosphoinositides in autophagy: current roles and future insights Palamiuc, Lavinia; Ravi, Archna; Emerling, Brooke M. The FEBS Journal, Vol. 287, Issue 2 https://doi.org/10.1111/febs.15127	journal	August 2019

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