Ion focusing

Cooks, Robert Graham; Baird, Zane; Peng, Wen-Ping

Title: Ion focusing

Patent · Tue Jan 17 00:00:00 EST 2017

OSTI ID:1339553

Cooks, Robert Graham; Baird, Zane; Peng, Wen-Ping

The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

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Research Organization:: Purdue Univ., West Lafayette, IN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-06ER15807

Assignee:: Purdue Research Foundation (West Lafayette, IN)

Patent Number(s):: 9,548,192

Application Number:: 14/936,223

OSTI ID:: 1339553

Resource Relation:: Patent File Date: 2015 Nov 09

Country of Publication:: United States

Language:: English

References (61)

System and method for the preparation of arrays of biological or other molecules Cooks, Robert Graham; Ouyang, Zheng https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7361311 US Patent Document 7,361,311	patent	April 2008
Redox chemistry in thin layers of organometallic complexes prepared using ion soft landing Peng, Wen-Ping; Johnson, Grant E.; Fortmeyer, Ivy C. Phys. Chem. Chem. Phys., Vol. 13, Issue 1, p. 267-275 https://doi.org/10.1039/C0CP01457E	journal	November 2011
Inkjet-Printed Microfluidic Multianalyte Chemical Sensing Paper Abe, Koji; Suzuki, Koji; Citterio, Daniel Analytical Chemistry, Vol. 80, Issue 18, p. 6928-6934 https://doi.org/10.1021/ac800604v	journal	September 2008
FLASH: A rapid method for prototyping paper-based microfluidic devices Martinez, Andres W.; Phillips, Scott T.; Wiley, Benjamin J. Lab on a Chip, Vol. 8, Issue 12, p. 2146-2150 https://doi.org/10.1039/B811135A	journal	January 2008
Photoemission Studies of Polythiophene and Polyphenyl Films Produced via Surface Polymerization by Ion-Assisted Deposition Tepavcevic, Sanja; Wroble, Amanda T.; Bissen, Mark The Journal of Physical Chemistry B, Vol. 109, Issue 15, p. 7134-7140 https://doi.org/10.1021/jp0451445	journal	April 2005
Processing of giant graphene molecules by soft-landing mass spectrometry Räder, Hans Joachim; Rouhanipour, Ali; Talarico, Anna Maria Nature Materials, Vol. 5, Issue 4, p. 276-280 https://doi.org/10.1038/nmat1597	journal	March 2006
Ion focusing Cooks, Robert Graham; Baird, Zane; Peng, Wen-Ping https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9184038 US Patent Document 9,184,038	patent	November 2015
Preparative Soft and Reactive Landing of Multiply Charged Protein Ions on a Plasma-Treated Metal Surface Volný, Michael; Elam, W. Timothy; Branca, Andrew Analytical Chemistry, Vol. 77, Issue 15, p. 4890-4896 https://doi.org/10.1021/ac0507136	journal	August 2005
Apparatus and methods for analyzing ions Clemmer, David E.; Merenbloom, Samuel I.; Koeniger, Stormy L. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8362420 US Patent Document 8,362,420	patent	January 2013
Direct Sample Analysis Ion Source Whitehouse, Craig M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120312980 US Patent Application 13/487037; 20120312980	patent-application	December 2012
Ambient Ionization Mass Spectrometry Huang, Min-Zong; Yuan, Cheng-Hui; Cheng, Sy-Chyi Annual Review of Analytical Chemistry, Vol. 3, Issue 1, p. 43-65 https://doi.org/10.1146/annurev.anchem.111808.073702	journal	June 2010
Laminated tube for the transport of charged particles contained in a gaseous medium Willoughby, Ross C.; Sheehan, Edward William https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6943347 US Patent Document 6,943,347	patent	September 2005
Gas-flow assisted ion transfer for mass spectrometry: Flow assisted ion transfer Garimella, Sandilya; Xu, Wei; Huang, Guangming Journal of Mass Spectrometry, Vol. 47, Issue 2, p. 201-207 https://doi.org/10.1002/jms.2955	journal	February 2012
Apparatus and method for focusing ions and charged particles at atmospheric pressure Sheehan, Edward William; Willoughby, Ross C. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6744041 US Patent Document 6,744,041	patent	June 2004
FAIMS apparatus having plural ion inlets and method therefore Guevremont, Roger; Purves, Randy; Barnett, David https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040232326 US Patent Application 10/861518; 20040232326	patent-application	November 2004
Low-Energy Ionic Collisions at Molecular Solids Cyriac, Jobin; Pradeep, T.; Kang, H. Chemical Reviews, Vol. 112, Issue 10, p. 5356-5411 https://doi.org/10.1021/cr200384k	journal	June 2012
Simulation of Ion Motion at Atmospheric Pressure: Particle Tracing Versus Electrokinetic Flow Wissdorf, Walter; Pohler, Larissa; Klee, Sonja Journal of The American Society for Mass Spectrometry, Vol. 23, Issue 2, p. 397-406 https://doi.org/10.1007/s13361-011-0290-x	journal	December 2011
Reactions of Organic Ions at Ambient Surfaces in a Solvent-Free Environment Badu-Tawiah, Abraham K.; Cyriac, Jobin; Cooks, R. Graham Journal of The American Society for Mass Spectrometry, Vol. 23, Issue 5, p. 842-849 https://doi.org/10.1007/s13361-012-0337-7	journal	January 2012
Practical implications of some recent studies in electrospray ionization fundamentals Cech, Nadja B.; Enke, Christie G. Mass Spectrometry Reviews, Vol. 20, Issue 6, p. 362-387 https://doi.org/10.1002/mas.10008	journal	January 2001
Microengineered vacuum interface for an ionization system Syms, Richard; Moseley, Richard William https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7786434 US Patent Document 7,786,434	patent	August 2010
Systems and methods for transfer of ions for analysis Ouyang, Zheng; Cooks, Robert Graham; Garimella, Sandilya Venkata https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8410431 US Patent Document 8,410,431	patent	April 2013
Ionization source utilizing a jet disturber in combination with an ion funnel and method of operation Smith, Richard D.; Kim, Taeman; Tang, Keqi https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20020185606 US Patent Application 09/860721; 20020185606	patent-application	December 2002
Direct monitoring of toxic compounds in air using a portable mass spectrometer Mulligan, Christopher C.; Justes, Dina R.; Noll, Robert. J. The Analyst, Vol. 131, Issue 4, p. 556-567 https://doi.org/10.1039/B517541K	journal	February 2006
Patterned Paper as a Platform for Inexpensive, Low-Volume, Portable Bioassays Martinez, Andres W.; Phillips, Scott T.; Butte, Manish J. Angewandte Chemie International Edition, Vol. 46, Issue 8, p. 1318-1320 https://doi.org/10.1002/anie.200603817	journal	February 2007
Efficient Atmospheric Pressure Interface for Mass Spectrometers and Method Makarov, Alexander A.; Pesch, Reinhold; Malek, Robert https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120161029 US Patent Application 13/413568; 20120161029	patent-application	June 2012
Nano-electrospray ionization mass spectrometry: addressing analytical problems beyond routine Karas, M.; Bahr, U.; Dülcks, T. Fresenius' Journal of Analytical Chemistry, Vol. 366, Issue 6-7, p. 669-676 https://doi.org/10.1007/s002160051561	journal	March 2000
The ion funnel: Theory, implementations, and applications Kelly, Ryan T.; Tolmachev, Aleksey V.; Page, Jason S. Mass Spectrometry Reviews, Vol. 29, Issue 2, p. 294-312 https://doi.org/10.1002/mas.20232	journal	April 2009
Segmented side-to-side FAIMS Guevremont, Roger; Purves, Randy; Barnett, David https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050151072 US Patent Application 10/503714; 20050151072	patent-application	July 2005
Spherical side-to-side FAIMS Guevremont, Roger; Purves, Randy; Barnett, David https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030226965 US Patent Application 10/359644; 20030226965	patent-application	December 2003
Sampling Wand for an Ion Trap Mass Spectrometer Hou, Keyong; Xu, Wei; Xu, Jian Analytical Chemistry, Vol. 83, Issue 5, p. 1857-1861 https://doi.org/10.1021/ac102962e	journal	March 2011
Method and device for non-contact sampling and detection Karpetsky, Timothy P. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7586092 US Patent Document 7,586,092	patent	September 2009
Grafting Crown Ether Alkali Host−Guest Complexes at Surfaces by Electrospray Ion Beam Deposition Thontasen, Nicha; Levita, Giacomo; Malinowski, Nikola The Journal of Physical Chemistry C, Vol. 114, Issue 41, p. 17768-17772 https://doi.org/10.1021/jp106123q	journal	September 2010
Ion transport device and modes of operation thereof Senko, Michael W.; Kovtoun, Viatcheslav V.; Atherton, Paul R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7781728 US Patent Document 7,781,728	patent	August 2010
Imaging of Surface Charge and the Mechanism of Desorption Electrospray Ionization Mass Spectrometry Gao, Liang; Li, Guangtao; Cyriac, Jobin The Journal of Physical Chemistry C, Vol. 114, Issue 12, p. 5331-5337 https://doi.org/10.1021/jp904960t	journal	October 2009
Desorption electrospray ionization and other ambient ionization methods: current progress and preview Ifa, Demian R.; Wu, Chunping; Ouyang, Zheng The Analyst, Vol. 135, Issue 4, p. 669-681 https://doi.org/10.1039/B925257F	journal	March 2010
Vibrational Spectroscopy and Mass Spectrometry for Characterization of Soft Landed Polyatomic Molecules Cyriac, Jobin; Li, Guangtao; Cooks, R. Graham Analytical Chemistry, Vol. 83, Issue 13, p. 5114-5121 https://doi.org/10.1021/ac200118f	journal	July 2011
Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization Takats, Z. Science, Vol. 306, Issue 5695, p. 471-473 https://doi.org/10.1126/science.1104404	journal	October 2004
Peptide Cross-Linking at Ambient Surfaces by Reactions of Nanosprayed Molecular Cations Badu-Tawiah, Abraham K.; Li, Anyin; Jjunju, Fred P. M. Angewandte Chemie International Edition, Vol. 51, Issue 37, p. 9417-9421 https://doi.org/10.1002/anie.201205044	journal	August 2012
Handheld Rectilinear Ion Trap Mass Spectrometer Gao, Liang; Song, Qingyu; Patterson, Garth E. Analytical Chemistry, Vol. 78, Issue 17, p. 5994-6002 https://doi.org/10.1021/ac061144k	journal	September 2006
The growth and modification of materials via ion–surface processing Hanley, Luke; Sinnott, Susan B. Surface Science, Vol. 500, Issue 1-3, p. 500-522 https://doi.org/10.1016/S0039-6028(01)01528-X	journal	March 2002
Three-dimensional microfluidic devices fabricated in layered paper and tape Martinez, A. W.; Phillips, S. T.; Whitesides, G. M. Proceedings of the National Academy of Sciences, Vol. 105, Issue 50, p. 19606-19611 https://doi.org/10.1073/pnas.0810903105	journal	December 2008
Simulation of Ion Motion in FAIMS through Combined Use of SIMION and Modified SDS Prasad, Satendra; Tang, Keqi; Manura, David Analytical Chemistry, Vol. 81, Issue 21, p. 8749-8757 https://doi.org/10.1021/ac900880v	journal	November 2009
In situ Raman spectroscopy of surfaces modified by ion soft landing Cyriac, Jobin; Wleklinski, Michael; Li, Guangtao The Analyst, Vol. 137, Issue 6, p. 1363-1369 https://doi.org/10.1039/C2AN16163J	journal	February 2012
The predictive power of SIMION/SDS simulation software for modeling ion mobility spectrometry instruments Lai, Hanh; McJunkin, Timothy R.; Miller, Carla J. International Journal of Mass Spectrometry, Vol. 276, Issue 1, p. 1-8 https://doi.org/10.1016/j.ijms.2008.06.011	journal	September 2008
Dielectric-Barrier Discharges: Their History, Discharge Physics, and Industrial Applications Kogelschatz, Ulrich Plasma Chemistry and Plasma Processing, Vol. 23, Issue 1, p. 1-46 https://doi.org/10.1023/A:1022470901385	journal	March 2003
Reactions of Microsolvated Organic Compounds at Ambient Surfaces: Droplet Velocity, Charge State, and Solvent Effects Badu-Tawiah, Abraham K.; Campbell, Dahlia I.; Cooks, R. Graham Journal of The American Society for Mass Spectrometry, Vol. 23, Issue 6, p. 1077-1084 https://doi.org/10.1007/s13361-012-0365-3	journal	March 2012
Method and apparatus for aerodynamic ion focusing Lee, Edgar D.; Lee, Milton L.; Rockwood, Alan L. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6992299 US Patent Document 6,992,299	patent	January 2006
Molecular ion yield enhancement in static secondary ion mass spectrometry by soft landing of protonated water clusters Li, Guangtao; Cyriac, Jobin; Gao, Liang Surface and Interface Analysis, Vol. 43, Issue 1-2, p. 498-501 https://doi.org/10.1002/sia.3161	journal	February 2010
Integrated ion focusing and gating optics for ion trap mass spectrometer Wells, Gregory J.; Schachterle, Steen D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030141449 US Patent Application 10/066124; 20030141449	patent-application
Electrospray ionization ion source with tunable charge reduction Frey, Brian L.; Smith, Lloyd M.; Westphall, Michael S. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070102634 US Patent Application 11/272450; 20070102634	patent-application	May 2007
Chemistry of mass-selected Au clusters deposited on sputter-damaged HOPG surfaces: The unique properties of Au₈ clusters Lim, Dong Chan; Dietsche, Rainer; Bubek, Moritz Chemical Physics Letters, Vol. 439, Issue 4-6, p. 364-368 https://doi.org/10.1016/j.cplett.2007.04.001	journal	May 2007
Method and system for desorption electrospray ionization Takats, Zoltan; Gologan, Bogdan; Wiseman, Justin https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7335897 US Patent Document 7,335,897	patent	February 2008
Discontinuous atmospheric pressure interface Ouyang, Zheng; Gao, Liang; Cooks, Robert Graham https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8304718 US Patent Document 8,304,718	patent	November 2012
Ionization and transmission efficiency in an electrospray ionization—mass spectrometry interface Page, Jason S.; Kelly, Ryan T.; Tang, Keqi Journal of the American Society for Mass Spectrometry, Vol. 18, Issue 9, p. 1582-1590 https://doi.org/10.1016/j.jasms.2007.05.018	journal	September 2007
Atmospheric pressure interface ion source and mass spectrometer Zhang, Xiaohua; Wang, Houle; Zhang, Hua https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140145075 US Patent Application 14/235905; 20140145075	patent-application	May 2014
Growth of phenylene vinylene thin films via surface polymerization by ion-assisted deposition Wroble, Amanda T.; Wildeman, Jurjen; Asunskis, Daniel J. Thin Solid Films, Vol. 516, Issue 21, p. 7386-7392 https://doi.org/10.1016/j.tsf.2008.02.024	journal	September 2008
Low-Cost Printing of Poly(dimethylsiloxane) Barriers To Define Microchannels in Paper Bruzewicz, Derek A.; Reches, Meital; Whitesides, George M. Analytical Chemistry, Vol. 80, Issue 9, p. 3387-3392 https://doi.org/10.1021/ac702605a	journal	May 2008
Non-proximate detection of explosives and chemical warfare agent simulants by desorption electrospray ionization mass spectrometry Cotte-Rodríguez, Ismael; Cooks, R. Graham Chem. Commun., Issue 28, p. 2968-2970 https://doi.org/10.1039/B606020J	journal	June 2006
Paper-Based Microfluidic Devices by Plasma Treatment Li, Xu; Tian, Junfei; Nguyen, Thanh Analytical Chemistry, Vol. 80, Issue 23, p. 9131-9134 https://doi.org/10.1021/ac801729t	journal	December 2008
Electro-Dynamic or Electro-Static Lens Coupled to a Stacked Ring Ion Guide Splendore, Maurizio A.; Wouters, Eloy R.; Senko, Michael W. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100090104 US Patent Application 12/252013; 20100090104	patent-application	April 2010
Current status of droplet evaporation in turbulent flows Birouk, M.; Gokalp, I. Progress in Energy and Combustion Science, Vol. 32, Issue 4, p. 408-423 https://doi.org/10.1016/j.pecs.2006.05.001	journal	July 2006

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