Human reduced folate carrier: translation of basic biology to cancer etiology and therapy
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journal
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March 2007 |
Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy
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journal
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April 2004 |
The molecular identity and characterization of a Proton-Coupled Folate Transporter—PCFT; biological ramifications and impact on the activity of pemetrexed—12 06 06
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journal
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March 2007 |
The human proton-coupled folate transporter
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journal
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December 2012 |
Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption
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journal
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December 2006 |
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction
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journal
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November 2007 |
Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model
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journal
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March 2008 |
Low-Dose Methotrexate Pharmacokinetics and Pharmacodynamics in the Therapy of Severe Psoriasis
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journal
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March 2005 |
Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance
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journal
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August 2012 |
The Antifolates
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journal
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June 2012 |
Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis
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journal
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November 2007 |
Preclinical Pharmacology Studies and the Clinical Development of a Novel Multitargeted Antifolate, MTA (LY231514)
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book
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January 1999 |
Therapeutic Targeting of a Novel 6-Substituted Pyrrolo [2,3-d]pyrimidine Thienoyl Antifolate to Human Solid Tumors Based on Selective Uptake by the Proton-Coupled Folate Transporter
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journal
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September 2011 |
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors
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journal
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August 2015 |
Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates
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journal
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February 2016 |
The folate receptor: What does it promise in tissue-targeted therapeutics?
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journal
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February 2007 |
Folate-Targeted Therapies for Cancer
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journal
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July 2010 |
Folate Receptor β Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages
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journal
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December 2009 |
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
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journal
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January 2006 |
Vintafolide: a novel targeted therapy for the treatment of folate receptor expressing tumors
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journal
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May 2015 |
Role of the folate receptor in ovarian cancer treatment: evidence, mechanism, and clinical implications
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journal
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January 2015 |
PRECEDENT: A Randomized Phase II Trial Comparing Vintafolide (EC145) and Pegylated Liposomal Doxorubicin (PLD) in Combination Versus PLD Alone in Patients With Platinum-Resistant Ovarian Cancer
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journal
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December 2013 |
BGC 945, a Novel Tumor-Selective Thymidylate Synthase Inhibitor Targeted to α-Folate Receptor–Overexpressing Tumors
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journal
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December 2005 |
Synthesis and Discovery of High Affinity Folate Receptor-Specific Glycinamide Ribonucleotide Formyltransferase Inhibitors with Antitumor Activity
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journal
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August 2008 |
Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier for Cellular Entry
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journal
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January 2010 |
Synthesis, Biological, and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity over the Reduced Folate Carrier That Inhibits β-Glycinamide Ribonucleotide Formyltransferase
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journal
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September 2011 |
Synthesis and Biological Activity of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Inhibitors of de Novo Purine Biosynthesis with Selectivity for Cellular Uptake by High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier
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journal
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February 2012 |
Discovery of 5-Substituted Pyrrolo[2,3- d ]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity
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journal
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December 2013 |
Tumor-Targeting with Novel Non-Benzoyl 6-Substituted Straight Chain Pyrrolo[2,3- d ]pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and Inhibition of de Novo Purine Nucleotide Biosynthesis
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journal
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October 2013 |
Structure–Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter
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journal
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September 2014 |
Preclinical and Clinical Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitors Lometrexol and LY309887
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book
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January 1999 |
AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase
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journal
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September 1996 |
Phase I dose-escalation and pharmacokinetic study of a novel folate analogue AG2034
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journal
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February 2001 |
Phase I and pharmacokinetic study of LY309887: a specific inhibitor of purine biosynthesis
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journal
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June 2001 |
Phase I Study of (6R)-5, 10-Dideazatetrahydrofolate: a Folate Antimetabolite Inhibitory to De Novo Purine Synthesis
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journal
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July 1993 |
Rational Design, Synthesis, Evaluation, and Crystal Structure of a Potent Inhibitor of Human GAR Tfase: 10-(Trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic Acid,
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journal
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May 2003 |
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
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journal
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April 2011 |
The Apo and Ternary Complex Structures of a Chemotherapeutic Target: Human Glycinamide Ribonucleotide Transformylase,
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journal
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June 2005 |
Structural basis for molecular recognition of folic acid by folate receptors
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journal
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July 2013 |
Isolation of Human cDNAs That Restore Methotrexate Sensitivity and Reduced Folate Carrier Activity in Methotrexate Transport-defective Chinese Hamster Ovary Cells
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journal
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July 1995 |
Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-d]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors over the Reduced Folate Carrier and Proton-Coupled Folate Transporter for Cellular Entry†
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journal
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April 2009 |
Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells
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journal
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May 1976 |
Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors
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journal
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July 2010 |
Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition
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journal
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August 2013 |
Novel 5-Substituted Pyrrolo[2,3- d ]pyrimidines as Dual Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase and as Potential Antitumor Agents
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journal
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February 2015 |
Molecular basis of antifolate resistance
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journal
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February 2007 |
Presenting your structures: the CCP 4 mg molecular-graphics software
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journal
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March 2011 |
Docking Validation Resources: Protein Family and Ligand Flexibility Experiments
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journal
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October 2010 |
DOCK 6: Impact of new features and current docking performance
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journal
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April 2015 |
ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
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journal
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July 2015 |
UCSF Chimera?A visualization system for exploratory research and analysis
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journal
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January 2004 |
Functional Loss of the Reduced Folate Carrier Enhances the Antitumor Activities of Novel Antifolates with Selective Uptake by the Proton-Coupled Folate Transporter
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journal
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June 2012 |
Protein Measurement with the Folin Phenol Reagent
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journal
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November 1951 |
Conversion of Uracil Deoxyriboside to Thymidine of Deoxyribonucleic acid
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journal
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June 1956 |
The Human Glycinamide Ribonucleotide Transformylase Domain: Purification, Characterization, and Kinetic Mechanism
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journal
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May 1997 |
Discovery of cryptophycin-1 and BCN-183577: Examples of strategies and problems in the detection of antitumor activity in mice
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journal
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September 1997 |
The Yeast HtrA Orthologue Ynm3 Is a Protease with Chaperone Activity that Aids Survival Under Heat Stress
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journal
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January 2009 |
Transplantable Syngeneic Rodent Tumors: Solid Tumors in Mice
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book
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November 2010 |
Treatment of human prostate tumors PC-3 and TSU-PR1 with standard and investigational agents in SCID mice
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journal
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June 1997 |
Long-Term Folate Deficiency Alters Folate Content and Distribution Differentially in Rat Tissues
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journal
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April 1992 |
Recent developments in the PHENIX software for automated crystallographic structure determination
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journal
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November 2003 |
PHENIX : building new software for automated crystallographic structure determination
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journal
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October 2002 |
Coot model-building tools for molecular graphics
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journal
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November 2004 |
Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard
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journal
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December 2007 |
XDS
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journal
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January 2010 |
The CCP4 suite programs for protein crystallography
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journal
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September 1994 |
Phaser crystallographic software
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journal
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July 2007 |
Refinement of Macromolecular Structures by the Maximum-Likelihood Method
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journal
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May 1997 |