Lignin conversion: Opportunities and challenges for the integrated biorefinery

Xie, Shangxian; Ragauskas, Arthur J.; Yuan, Joshua S.

doi:10.1089/ind.2016.0007

Title: Lignin conversion: Opportunities and challenges for the integrated biorefinery

Journal Article · Tue Jun 21 00:00:00 EDT 2016 · Industrial Biotechnology

DOI:https://doi.org/10.1089/ind.2016.0007· OSTI ID:1327723

Xie, Shangxian ^[1]; Ragauskas, Arthur J. ^[2]; Yuan, Joshua S. ^[1]

Texas A & M Univ., College Station, TX (United States)
Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

The utilization of lignin for fungible fuels and products represents one of the most imminent challenges in the modern biorefinery because most of the bioprocesses for lignocellulosic biofuels results in a lignin-containing waste stream. Considering lignin's abundance and relatively high energy content, this waste stream can be used as a feedstock for value-added products to improve the sustainability and economic feasibility of the biorefinery. Bioconversion of lignin with microbes recently emerged as an alternative lignin-valorization approach with significant potential. Typically, the microbial bioconversion of lignin requires three major steps: lignin depolymerization, aromatic compounds catabolism, and target product biosynthesis. In this review, we summarize the most recent advances in lignin bioconversion to address the challenges in each of the three steps. In conclusion, we further discuss strategies and perspectives for future research to address the challenges in bioconversion of lignin.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Joint Institute for Biological Sciences (JIBS)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1327723

Journal Information:: Industrial Biotechnology, Vol. 12, Issue 3; ISSN 1550-9087

Publisher:: Mary Ann Liebert, Inc.Copyright Statement

Country of Publication:: United States

Language:: English

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Alternatives for Chemical and Biochemical Lignin Valorization: Hot Topics from a Bibliometric Analysis of the Research Published During the 2000–2016 Period Abejón, Ricardo; Pérez-Acebo, Heriberto; Clavijo, Leonardo Processes, Vol. 6, Issue 8 https://doi.org/10.3390/pr6080098	journal	July 2018
Mechanism‐Guided Design of Highly Efficient Protein Secretion and Lipid Conversion for Biomanufacturing and Biorefining Xie, Shangxian; Sun, Su; Lin, Furong Advanced Science https://doi.org/10.1002/advs.201801980	journal	May 2019
Utilization of simultaneous saccharification and fermentation residues as feedstock for lipid accumulation in Rhodococcus opacus Le, Rosemary K.; Das, Parthapratim; Mahan, Kristina M. AMB Express, Vol. 7, Issue 1 https://doi.org/10.1186/s13568-017-0484-0	journal	September 2017
Combinatorial pretreatment and fermentation optimization enabled a record yield on lignin bioconversion Liu, Zhi-Hua; Xie, Shangxian; Lin, Furong Biotechnology for Biofuels, Vol. 11, Issue 1 https://doi.org/10.1186/s13068-018-1021-3	journal	January 2018
Systems and Synthetic Biology Approaches to Engineer Fungi for Fine Chemical Production Martins-Santana, Leonardo; Nora, Luisa C.; Sanches-Medeiros, Ananda Frontiers in Bioengineering and Biotechnology, Vol. 6 https://doi.org/10.3389/fbioe.2018.00117	journal	October 2018

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