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Title: Identifying a base in a nucleic acid

Patent ·
OSTI ID:1175233
; ;

Devices and techniques for hybridization of nucleic acids and for determining the sequence of nucleic acids. Arrays of nucleic acids are formed by techniques, preferably high resolution, light-directed techniques. Positions of hybridization of a target nucleic acid are determined by, e.g., epifluorescence microscopy. Devices and techniques are proposed to determine the sequence of a target nucleic acid more efficiently and more quickly through such synthesis and detection techniques.

Research Organization:
Affymetrix, Inc., Santa Clara, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG03-92ER81275
Assignee:
Affymetrix, Inc. (Santa Clara, CA)
Patent Number(s):
6,852,488
Application Number:
09/776,768
OSTI ID:
1175233
Country of Publication:
United States
Language:
English

References (8)

Likelihood DNA Sequencing By Hybridization journal December 1993
Sequencing of pools of nucleic acids on oligonucleotide arrays journal January 1993
An oligonucleotide hybridization approach to DNA sequencing journal October 1989
Maximum likelihood genetic sequence reconstruction from oligo content journal August 1994
Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: Evaluation using experimental models journal August 1992
DNA sequencing with chain-terminating inhibitors journal December 1977
Analysis of DNA Oligonucleotide Hybridization Data by Maximum Entropy book January 1993
A new method for sequencing DNA. journal February 1977

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