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Title: Method for monitoring the crystallization of an organic material from a liquid

Patent ·
OSTI ID:1175063

Method for monitoring the crystallization of at least one organic material from a liquid. According to the method, a liquid having at least one organic material capable of existing in at least one non-centrosymmetric phase is prepared. The liquid is interrogated with a laser beam at a chosen wavelength. As at least a portion of the at least one organic material crystallizes from the liquid, the intensity of any light scattered by the crystallized material at a wavelength equal to one-half the chosen wavelength of the interrogating laser beam is monitored. If the intensity of this scattered light, increases, then the crystals that form include at least one non-cetrosymmetric phase.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
W-7405-ENG-36
Assignee:
University Of California, The Regents Of
Patent Number(s):
6,800,487
Application Number:
10/259,345
OSTI ID:
1175063
Country of Publication:
United States
Language:
English

References (6)

The applicability of second harmonic generation for in situ measurement of induction time of selected crystallization systems journal June 1999
Polymorphs of Tamoxifen Citrate: Detailed Structural Characterization of the Stable Form journal March 1987
Quantitative Measurements of Multilayer Physical Adsorption on Heterogeneous Surfaces from Nonlinear Light Scattering journal August 1997
Dynamic Observation of a Thermally Activated Structure Change in 1,3,5-Triamino-2,4,6-trinitrobenzene (TATB) by Second Harmonic Generation journal July 1999
Application of solid-phase transition kinetics to the properties of HMX journal February 1983
Dynamic Measurement of the HMX β - δ Phase Transition by Second Harmonic Generation journal February 1999

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