Polymeric microspheres

Walt, David R.; Mandal, Tarun K.; Fleming, Michael S.

Title: Polymeric microspheres

Patent · Tue Apr 13 00:00:00 EDT 2004

OSTI ID:1174808

Walt, David R.; Mandal, Tarun K.; Fleming, Michael S.

The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.

View Patent

Cite

Export

Save

Research Organization:: Tufts Univ., Medford, MA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-000R22725

Assignee:: Tufts University (Medford, MA)

Patent Number(s):: 6,720,007

Application Number:: 10/033,389

OSTI ID:: 1174808

Country of Publication:: United States

Language:: English

References (79)

Thiolated Salmonella antibody immobilization onto the gold surface of piezoelectric quartz crystal1This paper was presented at the fifth World Congress on Biosensors, Berlin, Germany, 3–5 June 1998.1 Park, In-Seon; Kim, Namsoo Biosensors and Bioelectronics, Vol. 13, Issue 10 https://doi.org/10.1016/S0956-5663(98)00067-0	journal	November 1998
Surface-Confined Living Radical Polymerization for Coatings in Capillary Electrophoresis Huang, Xueying; Doneski, Leon J.; Wirth, Mary J. Analytical Chemistry, Vol. 70, Issue 19 https://doi.org/10.1021/ac980231c	journal	October 1998
Development of oral drug delivery system using floating microspheres Lee, J. -H.; Park, T. G.; Choi, H. -K. Journal of Microencapsulation, Vol. 16, Issue 6, p. 715-729 https://doi.org/10.1080/026520499288663	journal	January 1999
Encapsulation of Nanosized Silica by in Situ Polymerization of tert -Butyl Acrylate Monomer ^† Sondi, Ivan; Fedynyshyn, Theodore H.; Sinta, Roger Langmuir, Vol. 16, Issue 23 https://doi.org/10.1021/la000618m	journal	November 2000
Preparation and properties of uniform coated colloidal particles Kawahashi, Nobuo; Matijević, Egon Journal of Colloid and Interface Science, Vol. 138, Issue 2 https://doi.org/10.1016/0021-9797(90)90235-G	journal	September 1990
Self-Assembled Aggregates of Rod-Coil Block Copolymers and Their Solubilization and Encapsulation of Fullerenes Jenekhe, S. A. Science, Vol. 279, Issue 5358 https://doi.org/10.1126/science.279.5358.1903	journal	March 1998
Covalent Attachment and Derivatization of Poly( l -lysine) Monolayers on Gold Surfaces As Characterized by Polarization−Modulation FT-IR Spectroscopy Frey, Brian L.; Corn, Robert M. Analytical Chemistry, Vol. 68, Issue 18 https://doi.org/10.1021/ac9605861	journal	January 1996
Transmission Electron Microscopic Study of Cross-Sectional Morphologies of Core−Corona Polymeric Nanospheres ^† Serizawa, Takeshi; Takehara, Satoshi; Akashi, Mitsuru Macromolecules, Vol. 33, Issue 5 https://doi.org/10.1021/ma9907486	journal	March 2000
Variation of surface unevenness of anomalous composite polymer particles produced by the stepwise heterocoagulation of small particles onto large particle by heat treatment Okubo, M.; Miyachi, N.; Lu, Y. Colloid & Polymer Science, Vol. 272, Issue 3 https://doi.org/10.1007/BF00655497	journal	March 1994
Dynamics of Place-Exchange Reactions on Monolayer-Protected Gold Cluster Molecules Hostetler, Michael J.; Templeton, Allen C.; Murray, Royce W. Langmuir, Vol. 15, Issue 11 https://doi.org/10.1021/la981598f	journal	May 1999
New solid and hollow, magnetic and non-magnetic, organic-inorganic monodispersed hybrid microspheres: synthesis and characterization Bamnolker, Hannah; Nitzan, Boaz; Gura, Sigalit Journal of Materials Science Letters, Vol. 16, Issue 16, p. 1412-1415 https://doi.org/10.1023/A:1018565428355	journal	August 1997
Immobilization of Protein Molecules onto Homogeneous and Mixed Carboxylate-Terminated Self-Assembled Monolayers Patel, Nikin; Davies, Martyn C.; Hartshorne, Mark Langmuir, Vol. 13, Issue 24 https://doi.org/10.1021/la970933h	journal	November 1997
Enzyme Encapsulation in Layer-by-Layer Engineered Polymer Multilayer Capsules Caruso, Frank; Trau, Dieter; Möhwald, Helmuth Langmuir, Vol. 16, Issue 4 https://doi.org/10.1021/la991161n	journal	February 2000
Production of Hollow Polymeric Microspheres by Surface-Confined Living Radical Polymerization on Silica Templates Mandal, Tarun K.; Fleming, Michael S.; Walt, David R. Chemistry of Materials, Vol. 12, Issue 11 https://doi.org/10.1021/cm000514x	journal	November 2000
Silica Sol as a Nanoglue: Flexible Synthesis of Composite Aerogels Morris, Catherine A.; Anderson, Michele L.; Stroud, Rhonda M. Science, Vol. 284, Issue 5414, p. 622-624 https://doi.org/10.1126/science.284.5414.622	journal	April 1999
Polymerization of Methyl Methacrylate with the Carbon Tetrachloride/Dichlorotris- (triphenylphosphine)ruthenium(II)/Methylaluminum Bis(2,6-di-tert-butylphenoxide) Initiating System: Possibility of Living Radical Polymerization Kato, Mitsuru; Kamigaito, Masami; Sawamoto, Mitsuo Macromolecules, Vol. 28, Issue 5 https://doi.org/10.1021/ma00109a056	journal	September 1995
Preparation of core-shell polymer colloid particles by encapsulation Ottewill, R. H.; Schofield, A. B.; Waters, J. A. Colloid & Polymer Science, Vol. 275, Issue 3 https://doi.org/10.1007/s003960050081	journal	March 1997
Molecular Self-Assembly of Aliphatic Thiols on Gold Colloids Weisbecker, Carl S.; Merritt, Margaret V.; Whitesides, George M. Langmuir, Vol. 12, Issue 16 https://doi.org/10.1021/la950776r	journal	January 1996
Study of mechanical damage in rubber-toughened poly(methyl methacrylate) by single and multiple scattering of light Schirrer, R.; Lenke, R.; Boudouaz, J. Polymer Engineering & Science, Vol. 37, Issue 10 https://doi.org/10.1002/pen.11823	journal	October 1997
Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions Frens, G. Nature Physical Science, Vol. 241, Issue 105, p. 20-22 https://doi.org/10.1038/physci241020a0	journal	January 1973
Molecular Recognition on Functionalized Self-Assembled Monolayers of Alkanethiols on Gold Motesharei, Kianoush; Myles, David C. Journal of the American Chemical Society, Vol. 120, Issue 29 https://doi.org/10.1021/ja973166h	journal	July 1998
Molecular Recognition by Self-Assembled Monolayers of Cavitand Receptors Schierbaum, K. D.; Weiss, T.; van Veizen, E. U. T. Science, Vol. 265, Issue 5177 https://doi.org/10.1126/science.265.5177.1413	journal	September 1994
Assembly of Latex Particles by Using Emulsion Droplets as Templates. 2. Ball-like and Composite Aggregates Velev, O. D.; Furusawa, K.; Nagayama, K. Langmuir, Vol. 12, Issue 10 https://doi.org/10.1021/la950679y	journal	January 1996
Formation of monolayer films by the spontaneous assembly of organic thiols from solution onto gold Bain, Colin D.; Troughton, E. Barry; Tao, Yu Tai Journal of the American Chemical Society, Vol. 111, Issue 1, p. 321-335 https://doi.org/10.1021/ja00183a049	journal	January 1989
Surface plasmon resonance of colloidal Au-modified gold films Lyon, L. Andrew; Musick, Michael D.; Smith, Patrick C. Sensors and Actuators B: Chemical, Vol. 54, Issue 1-2 https://doi.org/10.1016/S0925-4005(98)00329-3	journal	January 1999
A Strategy for the Generation of Surfaces Presenting Ligands for Studies of Binding Based on an Active Ester as a Common Reactive Intermediate: A Surface Plasmon Resonance Study Lahiri, Joydeep; Isaacs, Lyle; Tien, Joe Analytical Chemistry, Vol. 71, Issue 4 https://doi.org/10.1021/ac980959t	journal	February 1999
Surface Plasmon Resonance Imaging Measurements of DNA Hybridization Adsorption and Streptavidin/DNA Multilayer Formation at Chemically Modified Gold Surfaces Jordan, Claire E.; Frutos, Anthony G.; Thiel, Andrew J. Analytical Chemistry, Vol. 69, Issue 24 https://doi.org/10.1021/ac9709763	journal	December 1997
Emulsion Polymerization of Voided Particles by Encapsulation of a Nonsolvent McDonald, Charles J.; Bouck, Kevin. J.; Chaput, A. Bruce Macromolecules, Vol. 33, Issue 5 https://doi.org/10.1021/ma991284e	journal	March 2000
Electrostatic Self-Assembly of Silica Nanoparticle−Polyelectrolyte Multilayers on Polystyrene Latex Particles Caruso, Frank; Lichtenfeld, Heinz; Giersig, Michael Journal of the American Chemical Society, Vol. 120, Issue 33 https://doi.org/10.1021/ja9815024	journal	August 1998
Preparation and evaluation of a polymer-coated zirconia reversed-phase chromatographic support Rigney, M. P.; Weber, T. P.; Carr, P. W. Journal of Chromatography A, Vol. 484 https://doi.org/10.1016/S0021-9673(01)88975-5	journal	December 1989
One-Pot Colorimetric Differentiation of Polynucleotides with Single Base Imperfections Using Gold Nanoparticle Probes Storhoff, James J.; Elghanian, Robert; Mucic, Robert C. Journal of the American Chemical Society, Vol. 120, Issue 9 https://doi.org/10.1021/ja972332i	journal	March 1998
Synthetic process to control the total size and component distribution of multilayer magnetic composite particles Furusawa, K.; Nagashima, K.; Anzai, C. Colloid & Polymer Science, Vol. 272, Issue 9 https://doi.org/10.1007/BF00652379	journal	September 1994
Production of Hollow Microspheres from Nanostructured Composite Particles Caruso, Frank; Caruso, Rachel A.; Möhwald, Helmuth Chemistry of Materials, Vol. 11, Issue 11 https://doi.org/10.1021/cm991083p	journal	November 1999
Gold Particles as Templates for the Synthesis of Hollow Polymer Capsules. Control of Capsule Dimensions and Guest Encapsulation Marinakos, Stella M.; Novak, James P.; Brousseau, Louis C. Journal of the American Chemical Society, Vol. 121, Issue 37 https://doi.org/10.1021/ja990945k	journal	September 1999
Preparation of composite latex particles by engulfment Ottewill, R. H.; Schofield, A. B.; Waters, J. A. Colloid & Polymer Science, Vol. 274, Issue 8 https://doi.org/10.1007/BF00654672	journal	August 1996
The scattering by grafted polymers Auroy, Philippe; Auvray, Loïc; Leger, Liliane Physica A: Statistical Mechanics and its Applications, Vol. 172, Issue 1-2 https://doi.org/10.1016/0378-4371(91)90326-8	journal	March 1991
Investigation of intermediate steps in the self-assembly of n-alkanethiols on gold surfaces by soft x-ray spectroscopy Haehner, G.; Woell, C.; Buck, M. Langmuir, Vol. 9, Issue 8 https://doi.org/10.1021/la00032a005	journal	August 1993
Radical Living Graft Polymerization on the Surface of Polymeric Materials Yang, Wantai; Rånby, Bengt Macromolecules, Vol. 29, Issue 9 https://doi.org/10.1021/ma9515543	journal	January 1996
“Living” Free Radical Polymerization: A Unique Technique for the Preparation of Controlled Macromolecular Architectures Hawker, Craig J. Accounts of Chemical Research, Vol. 30, Issue 9 https://doi.org/10.1021/ar960248m	journal	September 1997
DNA-Directed Synthesis of Binary Nanoparticle Network Materials Mucic, Robert C.; Storhoff, James J.; Mirkin, Chad A. Journal of the American Chemical Society, Vol. 120, Issue 48 https://doi.org/10.1021/ja982721s	journal	December 1998
Copper(I)-Catalyzed Atom Transfer Radical Polymerization Patten, Timothy E.; Matyjaszewski, Krzysztof Accounts of Chemical Research, Vol. 32, Issue 10 https://doi.org/10.1021/ar9501434	journal	October 1999
Synthesis of Cored Dendrimers Wendland, Michael S.; Zimmerman, Steven C. Journal of the American Chemical Society, Vol. 121, Issue 6 https://doi.org/10.1021/ja983097m	journal	February 1999
Randomly Ordered Addressable High-Density Optical Sensor Arrays Michael, Karri L.; Taylor, Laura C.; Schultz, Sandra L. Analytical Chemistry, Vol. 70, Issue 7 https://doi.org/10.1021/ac971343r	journal	April 1998
Encapsulation of Biologicals within Silicate, Siloxane, and Hybrid Sol−Gel Polymers: An Efficient and Generic Approach Gill, Iqbal; Ballesteros, Antonio Journal of the American Chemical Society, Vol. 120, Issue 34 https://doi.org/10.1021/ja9814568	journal	September 1998
Heterocoagulation in mixed dispersions—effect of particle size, size ratio, relative concentration, and surface potential of colloidal components Harding, R. Derek Journal of Colloid and Interface Science, Vol. 40, Issue 2 https://doi.org/10.1016/0021-9797(72)90006-9	journal	August 1972
Assembly of Latex Particles by Using Emulsion Droplets as Templates. 1. Microstructured Hollow Spheres Velev, O. D.; Furusawa, K.; Nagayama, K. Langmuir, Vol. 12, Issue 10 https://doi.org/10.1021/la9506786	journal	January 1996
Monolayer vibrational spectroscopy by infrared-visible sum generation at metal and semiconductor surfaces Harris, A. L.; Chidsey, C. E. D.; Levinos, N. J. Chemical Physics Letters, Vol. 141, Issue 4 https://doi.org/10.1016/0009-2614(87)85037-6	journal	November 1987
Construction of simple gold nanoparticle aggregates with controlled plasmon–plasmon interactions Westcott, Sarah L.; Oldenburg, Steven J.; Lee, T. Randall Chemical Physics Letters, Vol. 300, Issue 5-6 https://doi.org/10.1016/S0009-2614(98)01410-9	journal	February 1999
Vesicle-Templated Polymer Hollow Spheres Hotz, Jutta; Meier, Wolfgang Langmuir, Vol. 14, Issue 5 https://doi.org/10.1021/la971080w	journal	March 1998
Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles Elghanian, Robert; Storhoff, James J.; Mucic, Robert C. Science, Vol. 277, Issue 5329, p. 1078-1081 https://doi.org/10.1126/science.277.5329.1078	journal	August 1997
Staining of cell surface human CD4 with 2'-F-pyrimidine-containing RNA aptamers for flow cytometry Davis, K. Nucleic Acids Research, Vol. 26, Issue 17 https://doi.org/10.1093/nar/26.17.3915	journal	September 1998
Surface-Initiated Radical Polymerization on Porous Silica Huang, Xueying; Wirth, Mary J. Analytical Chemistry, Vol. 69, Issue 22 https://doi.org/10.1021/ac9704523	journal	November 1997
Manipulation of Surface Properties by Patterning of Covalently Bound Polymer Brushes Husemann, Marc; Morrison, Michael; Benoit, Didier Journal of the American Chemical Society, Vol. 122, Issue 8 https://doi.org/10.1021/ja991450y	journal	March 2000
Interfacial aspects of latex ipns for toughening polycarbonate. I. Synthesis and characterization Hu, R.; Dimonie, V. L.; El-Aasser, M. S. Journal of Applied Polymer Science, Vol. 58, Issue 2 https://doi.org/10.1002/app.1995.070580217	journal	October 1995
Gold and Silver Nanoparticles Functionalized by the Adsorption of Dialkyl Disulfides Porter, Lon A.; Ji, David; Westcott, Sarah L. Langmuir, Vol. 14, Issue 26 https://doi.org/10.1021/la980870i	journal	November 1998
Laser Desorption Fourier Transform Mass Spectrometry Exchange Studies of Air-Oxidized Alkanethiol Self-Assembled Monolayers on Gold Scott, Jill R.; Baker, Laura S.; Everett, W. Russell Analytical Chemistry, Vol. 69, Issue 14 https://doi.org/10.1021/ac9609642	journal	July 1997
Core-shell structured latex particles. I. Copolymerization of styrene/benzyl methacrylate as a choice for shell material and characterization of poly(n-butyl acrylate) core latex particles Segall, I.; Dimonie, V. L.; El-Aasser, M. S. Journal of Applied Polymer Science, Vol. 58, Issue 2 https://doi.org/10.1002/app.1995.070580218	journal	October 1995
Preparation of hollow spherical particles of yttrium compounds Kawahashi, Nobuo; Matijevic´, Egon Journal of Colloid and Interface Science, Vol. 143, Issue 1 https://doi.org/10.1016/0021-9797(91)90442-B	journal	April 1991
Core—shell structured latex particles. II. Synthesis and characterization of poly(n-butyl acrylate)/poly(benzyl methacrylate—styrene) structured latex particles Segall, I.; Dimonie, V. L.; El-Aasser, M. S. Journal of Applied Polymer Science, Vol. 58, Issue 2 https://doi.org/10.1002/app.1995.070580219	journal	October 1995
Gadolinium-Loaded Nanoparticles: New Contrast Agents for Magnetic Resonance Imaging Reynolds, Charles H.; Annan, Nikoi; Beshah, Kebede Journal of the American Chemical Society, Vol. 122, Issue 37 https://doi.org/10.1021/ja001426g	journal	September 2000
Template Synthesis of One-Dimensional Au, Au−Poly(pyrrole), and Poly(pyrrole) Nanoparticle Arrays Marinakos, Stella M.; Brousseau, Louis C.; Jones, Angela Chemistry of Materials, Vol. 10, Issue 5 https://doi.org/10.1021/cm980059t	journal	May 1998
Polymeric microcapsule arrays Martin, Charles R.; Parthasarathy, Ranjani V. Advanced Materials, Vol. 7, Issue 5 https://doi.org/10.1002/adma.19950070519	journal	May 1995
Colloidal Au-Enhanced Surface Plasmon Resonance Immunosensing Lyon, L. Andrew; Musick, Michael D.; Natan, Michael J. Analytical Chemistry, Vol. 70, Issue 24 https://doi.org/10.1021/ac9809940	journal	December 1998
Nanoengineering of Inorganic and Hybrid Hollow Spheres by Colloidal Templating Caruso, F. Science, Vol. 282, Issue 5391 https://doi.org/10.1126/science.282.5391.1111	journal	November 1998
Cocondensation of Organosilica Hybrid Shells on Nanoparticle Templates: A Direct Synthetic Route to Functionalized Core−Shell Colloids Hall, Simon R.; Davis, Sean A.; Mann, Stephen Langmuir, Vol. 16, Issue 3 https://doi.org/10.1021/la9909143	journal	February 2000
Preparation of Structurally Well-Defined Polymer−Nanoparticle Hybrids with Controlled/Living Radical Polymerizations von Werne, Timothy; Patten, Timothy E. Journal of the American Chemical Society, Vol. 121, Issue 32 https://doi.org/10.1021/ja991108l	journal	August 1999
Controlled/"living" radical polymerization. atom transfer radical polymerization in the presence of transition-metal complexes Wang, Jin-Shan; Matyjaszewski, Krzysztof Journal of the American Chemical Society, Vol. 117, Issue 20 https://doi.org/10.1021/ja00125a035	journal	May 1995
Stability and Self-Exchange in Alkanethiol Monolayers Schlenoff, Joseph B.; Li, Ming; Ly, Hiep Journal of the American Chemical Society, Vol. 117, Issue 50 https://doi.org/10.1021/ja00155a016	journal	December 1995
Shell Cross-Linked Knedels: A Synthetic Study of the Factors Affecting the Dimensions and Properties of Amphiphilic Core-Shell Nanospheres Thurmond, K. Bruce; Kowalewski, Tomasz; Wooley, Karen L. Journal of the American Chemical Society, Vol. 119, Issue 28 https://doi.org/10.1021/ja9710520	journal	July 1997
Solubilization and Encapsulation of Fullerenes by Amphiphilic Block Copolymers Chen, X. Linda; Jenekhe, Samson A. Langmuir, Vol. 15, Issue 23 https://doi.org/10.1021/la9810253	journal	November 1999
Surface Initiation of Living Radical Polymerization for Growth of Tethered Chains of Low Polydispersity Huang, X.; Wirth, M. J. Macromolecules, Vol. 32, Issue 5 https://doi.org/10.1021/ma981304x	journal	March 1999
Efficient Raman Enhancement and Intermittent Light Emission Observed in Single Gold Nanocrystals Krug, John T.; Wang, Geoffrey D.; Emory, Steven R. Journal of the American Chemical Society, Vol. 121, Issue 39 https://doi.org/10.1021/ja992058n	journal	October 1999
Polystyrene- b lock -poly(2-cinnamoylethyl methacrylate) Nanospheres with Cross-Linked Shells Ding, Jianfu; Liu, Guojun Macromolecules, Vol. 31, Issue 19 https://doi.org/10.1021/ma980710d	journal	September 1998
Controlled/"Living" Radical Polymerization. Halogen Atom Transfer Radical Polymerization Promoted by a Cu(I)/Cu(II) Redox Process Wang, Jin-Shan; Matyjaszewski, Krzysztof Macromolecules, Vol. 28, Issue 23 https://doi.org/10.1021/ma00127a042	journal	November 1995
A colorimetric method for determining low concentrations of mercaptans Ellman, George L. Archives of Biochemistry and Biophysics, Vol. 74, Issue 2 https://doi.org/10.1016/0003-9861(58)90014-6	journal	April 1958
Confirmation of immobilizing IgG on different surfaces with AFM and impedance investigations of a Pt electrode during the immobilization Feng, Chang-Dong; Ming, Yu-Dong; Hesketh, Peter J. Sensors and Actuators B: Chemical, Vol. 36, Issue 1-3 https://doi.org/10.1016/S0925-4005(97)80110-4	journal	October 1996
Controlled Graft Polymerization of Methyl Methacrylate on Silicon Substrate by the Combined Use of the Langmuir−Blodgett and Atom Transfer Radical Polymerization Techniques Ejaz, Muhammad; Yamamoto, Shinpei; Ohno, Kohji Macromolecules, Vol. 31, Issue 17 https://doi.org/10.1021/ma980240n	journal	August 1998
A study of the nucleation and growth processes in the synthesis of colloidal gold Turkevich, John; Stevenson, Peter Cooper; Hillier, James Discussions of the Faraday Society, Vol. 11 https://doi.org/10.1039/df9511100055	journal	January 1951
Self-Assembled Monolayers Formed on Electroless Gold Deposited on Silica Gel: A Potential Stationary Phase for Biological Assays Dubrovsky, Timothy B.; Hou, Zhizhong; Stroeve, Pieter Analytical Chemistry, Vol. 71, Issue 2 https://doi.org/10.1021/ac9804745	journal	January 1999

Similar Records

Method for introduction of gases into microspheres

Patent · Tue Mar 24 00:00:00 EST 1981 · OSTI ID:1174808

Hendricks, C D; Koo, J C; Rosencwaig, A

Method for introduction of gases into microspheres

Patent · Thu Jan 01 00:00:00 EST 1981 · OSTI ID:1174808

Hendricks, Charles D; Koo, Jackson C; Rosencwaig, Allan

Fast synthesis, formation mechanism, and control of shell thickness of CuS–polystyrene core–shell microspheres

Journal Article · Sat Sep 15 00:00:00 EDT 2012 · Materials Research Bulletin · OSTI ID:1174808

Zhao, Li-min; Shao, Xin; Yin, Yi-bin; +1 more

Related Subjects

36 MATERIALS SCIENCE

Title: Polymeric microspheres

Citation Formats

References (79)

Similar Records

Related Subjects