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Title: Multichannel microscale system for high throughput preparative separation with comprehensive collection and analysis

Patent ·
OSTI ID:1174610

A modular multiple lane or capillary electrophoresis (chromatography) system that permits automated parallel separation and comprehensive collection of all fractions from samples in all lanes or columns, with the option of further on-line automated sample fraction analysis, is disclosed. Preferably, fractions are collected in a multi-well fraction collection unit, or plate (40). The multi-well collection plate (40) is preferably made of a solvent permeable gel, most preferably a hydrophilic, polymeric gel such as agarose or cross-linked polyacrylamide.

Research Organization:
Beckman Coulter, Inc., Fullerton, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-90ER60985
Assignee:
Beckman Coulter, Inc. (Fullerton, CA)
Patent Number(s):
6,660,149
Application Number:
09/530,118
OSTI ID:
1174610
Country of Publication:
United States
Language:
English

References (3)

Automated DNA fragment collection by capillary array gel electrophoresis in search of differentially expressed genes journal January 2000
Capillary electrophoresis—matrix-assisted laser-desorption ionization mass spectrometry of proteins journal October 1994
Multiple Sequential Fraction Collection of Peptides and Glycopeptides by High-Performance Capillary Electrophoresis journal September 1995

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