Tetraethylene glycol promoted two-step, one-pot rapid synthesis of indole-3-[1-11C]acetic acid
Journal Article
·
· Tetrahedron Letters
- Brookhaven National Laboratory (BNL), Upton, NY (United States); Stony Brook Univ., Stony Brook, NY (United States)
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
An operationally friendly, two-step, one-pot process has been developed for the rapid synthesis of carbon-11 labeled indole-3-acetic acid ([11]IAA or [11]auxin). By replacing an aprotic polar solvent with tetraethylene glycol, nucleophilic [11]cyanation and alkaline hydrolysis reactions were performed consecutively in a single pot without a time-consuming intermediate purification step. The entire production time for this updated procedure is 55 min, which dramatically simplifies the entire synthesis and reduces the starting radioactivity required for a whole plant imaging study.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States). Positron Emission Tomography (PET) Facility
- Sponsoring Organization:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- Grant/Contract Number:
- DE-SC00112704
- OSTI ID:
- 1167431
- Alternate ID(s):
- OSTI ID: 1433587
- Report Number(s):
- BNL-107233-2014-JA; R&D Project: MO-085; KP1602010
- Journal Information:
- Tetrahedron Letters, Vol. 56, Issue 3; ISSN 0040-4039
- Publisher:
- ElsevierCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Cited by: 7 works
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