Biocompatible implants and methods of making and attaching the same

Rowley, Adrian P; Laude, Lucien D; Humayun, Mark S; Weiland, James D; Lotfi, Atoosa; Markland, Jr., Francis S

Title: Biocompatible implants and methods of making and attaching the same

Patent · Tue Oct 07 00:00:00 EDT 2014

OSTI ID:1160226

Rowley, Adrian P; Laude, Lucien D; Humayun, Mark S; Weiland, James D; Lotfi, Atoosa; Markland, Jr., Francis S

The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided.

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Research Organization:: Doheny Eye Institute, Los Angeles, CA (United States)

Sponsoring Organization:: USDOE

Assignee:: Doheny Eye Institute (Los Angeles, CA)

Patent Number(s):: 8,852,290

Application Number:: 12/041,651

OSTI ID:: 1160226

Resource Relation:: Patent File Date: 2008 Mar 03

Country of Publication:: United States

Language:: English

References (18)

Laser generated high electron density source Lee, Chunghsin; Oettinger, Peter E. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4346330 US Patent Document 4,346,330	patent	August 1982
Human collagen processing and autoimplant use Kelman, Charles D.; DeVore, Dale P. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4969912 US Patent Document 4,969,912	patent	November 1990
Surface-active macromonomers Valint, Jr., Paul L.; McGee, Joseph A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5177165 US Patent Document 5,177,165	patent	January 1993
Removal of surface contaminants by irradiation from a high energy source Engelsberg, Audrey C.; Dehais, Joseph A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5531857 US Patent Document 5,531,857	patent	July 1996
Corneal onlays Steele, John Gerard; Holden, Brien Anthony; Sweeney, Deborah https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5713957 US Patent Document 5,713,957	patent	February 1998
Peptide-coated implants and methods for producing same Meyer, Jörg; Jonczyk, Alfred; Nies, Berthold https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6280760 US Patent Document 6,280,760	patent	August 2001
Chronically implantable retinal prosthesis Shire, Doug; Rizzo, Joseph F.; Wyatt, Jr., John L. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6324429 US Patent Document 6,324,429	patent	November 2001
Contortrostain (CN) and methods for its use in preventing metastasis and other conditions Markland, Jr., Francis S.; Zhou, Qing https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6710030 US Patent Document 6,710,030	patent	March 2004
Optical information storage medium and method for manufacturing the same Hsiao, Tsai-Chu https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7163730 US Patent Document 7,163,730	patent	January 2007
Single-piece accomodating intraocular lens system Zadno-Azizi, Gholam-Reza https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030078658 US Patent Application 10/207718; 20030078658	patent-application	April 2003
Transistor manufacturing method, electrooptical apparatus and electronic apparatus Aoki, Takashi https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040248429 US Patent Application 10/804013; 20040248429	patent-application	December 2004
Method for manufacturing semiconductor device Misawa, Kaori; Ohashi, Naofumi https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050191847 US Patent Application 11/010344; 20050191847	patent-application	September 2005
Method of pulsed laser assisted surface modification Talton, James D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060051522 US Patent Application 10/502022; 20060051522	patent-application	March 2006
Nanorods and other materials from condensed phase conversion and growth instead of from vapor Geohegan, David B.; Seals, Roland D.; Puretzky, ALex A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060111005 US Patent Application 11/037578; 20060111005	patent-application	May 2006
Medical device applications of nanostructured surfaces Dubrow, Robert S.; Bock, Lawrence A.; Daniels, R. Hugh https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060204738 US Patent Application 11/330722; 20060204738	patent-application	September 2006
Controlled vapor deposition of biocompatible coatings for medical devices Kobrin, Boris; Nowak, Romuald; Chinn, Jeffrey D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060251795 US Patent Application 11/123487; 20060251795	patent-application	November 2006
Polypeptides and antibodies Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070179086 US Patent Application 11/512051; 20070179086	patent-application	August 2007
Laser ablation processes investigated using inductively coupled plasma–atomic emission spectroscopy (ICP–AES) Mao, X. L.; Ciocan, A. C.; Borisov, O. V. Applied Surface Science, Vol. 127-129, p. 262-268 https://doi.org/10.1016/S0169-4332(97)00787-3	journal	May 1998

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