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Title: Medical implants and methods of making medical implants

Patent ·
OSTI ID:1159830
; ; ; ; ;

A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC06-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
8,834,913
Application Number:
12/648,106
OSTI ID:
1159830
Country of Publication:
United States
Language:
English

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Mitomycin C and the endoscopic treatment of laryngotracheal stenosis: Are two applications better than one? journal February 2009
Controlled comparison between betamethasone gel and lidocaine jelly applied over tracheal tube to reduce postoperative sore throat, cough, and hoarseness of voice journal February 2008
Long-term Experience With Bacillus Calmette-Guerin Therapy of Upper Urinary Tract Transitional Cell Carcinoma in Patients Not Eligible for Surgery journal October 2002
Poly(ethylene carbonate): A thermoelastic and biodegradable biomaterial for drug eluting stent coatings? journal February 2007
Effect of Surface Properties on Nanoparticle–Cell Interactions journal January 2010
A Pollen Extract (Cernilton) in Patients with Inflammatory Chronic Prostatitis–Chronic Pelvic Pain Syndrome: A Multicentre, Randomised, Prospective, Double-Blind, Placebo-Controlled Phase 3 Study journal September 2009
Controlled release of sirolimus from a multilayered PLGA stent matrix journal November 2006
Treatment with melagatran alone or in combination with thrombolytic therapy reduced ischemic brain injury journal September 2008
Intravesical Pharmacotherapy for Non–Muscle-Invasive Bladder Cancer: A Critical Analysis of Currently Available Drugs, Treatment Schedules, and Long-Term Results journal January 2008
Biodegradation of poly(l-lactide-co-glycolide) tube stents in bile journal April 2008
Spray-As-You-Go Airway Topical Anesthesia in Patients with a Difficult Airway: A Randomized, Double-Blind Comparison of 2% and 4% Lidocaine journal January 2009
Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic journal January 2009
Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia journal January 2009
Synthesis and characterization of biodegradable low molecular weight aliphatic polyesters and their use in protein-delivery systems journal January 2003
Influence of metal alloy and the profile of coronary stents in patients with multivessel coronary disease journal January 2011
The influence of carbon fibres on the resorption time and mechanical properties of the lactide–glycolide co-polymer journal January 2007
Sintering Technique for the Preparation of Polymer Matrices for the Controlled Release of Macromolecules journal August 1984
Selection of coronary stents journal September 2002
A novel nanostructured poly(lactic-co-glycolic-acid)–multi-walled carbon nanotube composite for blood-contacting applications: Thrombogenicity studies journal November 2009
Neointimal coverage of sirolimus-eluting stents at 6-month follow-up: evaluated by optical coherence tomography journal April 2007
Crystallization processes in pharmaceutical technology and drug delivery design journal April 2000
Study on the preparation and characterization of biodegradable polylactide/multi-walled carbon nanotubes nanocomposites journal July 2007
Drug-Eluting Bioresorbable Stents for Various Applications journal August 2006

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Stents having controlled elution patent November 2016
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