Methods for threshold determination in multiplexed assays
Patent
·
OSTI ID:1134715
Methods for determination of threshold values of signatures comprised in an assay are described. Each signature enables detection of a target. The methods determine a probability density function of negative samples and a corresponding false positive rate curve. A false positive criterion is established and a threshold for that signature is determined as a point at which the false positive rate curve intersects the false positive criterion. A method for quantitative analysis and interpretation of assay results together with a method for determination of a desired limit of detection of a signature in an assay are also described.
- Research Organization:
- Univ. of California, Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-48
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA)
- Patent Number(s):
- 8,762,068
- Application Number:
- 12/607,956
- OSTI ID:
- 1134715
- Resource Relation:
- Patent File Date: 2009 Oct 28
- Country of Publication:
- United States
- Language:
- English
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