System and process for pulsed multiple reaction monitoring

Belov, Mikhail E

Title: System and process for pulsed multiple reaction monitoring

Patent · Fri May 17 00:00:00 EDT 2013

OSTI ID:1084053

Belov, Mikhail E

A new pulsed multiple reaction monitoring process and system are disclosed that uses a pulsed ion injection mode for use in conjunction with triple-quadrupole instruments. The pulsed injection mode approach reduces background ion noise at the detector, increases amplitude of the ion signal, and includes a unity duty cycle that provides a significant sensitivity increase for reliable quantitation of proteins/peptides present at attomole levels in highly complex biological mixtures.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RLO5640

Assignee:: Battelle Memorial Institute (Richland, WA)

Patent Number(s):: 8,440,963

Application Number:: 12/871,685

OSTI ID:: 1084053

Country of Publication:: United States

Language:: English

References (15)

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