Method to determine transcriptional regulation pathways in organisms
The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory activities of such regulating polypeptides. More specifically, the invention provides a new method for identifying regulatory dependencies between biochemical species in a cell. In particular embodiments, provided are computer-implemented methods for identifying a regulatory interaction between a transcription factor and a gene target of the transcription factor, or between a transcription factor and a set of gene targets of the transcription factor. Further provided are genome-scale methods for predicting regulatory interactions between a set of transcription factors and a corresponding set of transcriptional target substrates thereof.
- Research Organization:
- Boston University (Boston, MA)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-04ER63803
- Assignee:
- Trustees of Boston University (Boston, MA)
- Patent Number(s):
- 8,306,752
- Application Number:
- 12/271,944
- OSTI ID:
- 1080438
- Country of Publication:
- United States
- Language:
- English
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