Synthetic LDL as targeted drug delivery vehicle
Patent
·
OSTI ID:1061284
- Berkeley, CA
- Richmond, CA
The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.
- Research Organization:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-05CH11231
- Assignee:
- The Regents of the University of California (Oakland, CA); Children's Hospital & Research Center Oakland (Oakland, CA)
- Patent Number(s):
- 8,252,338
- Application Number:
- 12/084,845
- OSTI ID:
- 1061284
- Country of Publication:
- United States
- Language:
- English
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