Guidance on health effects of toxic chemicals. Safety Analysis Report Update Program

Technical Report · Tue Feb 01 00:00:00 EST 1994

DOI:https://doi.org/10.2172/10136228· OSTI ID:10136228

Foust, C B; Griffin, G D; Munro, N B; Socolof, M L

Martin Marietta Energy Systems, Inc. (MMES), and Martin Marietta Utility Services, Inc. (MMUS), are engaged in phased programs to update the safety documentation for the existing US Department of Energy (DOE)-owned facilities. The safety analysis of potential toxic hazards requires a methodology for evaluating human health effects of predicted toxic exposures. This report provides a consistent set of health effects and documents toxicity estimates corresponding to these health effects for some of the more important chemicals found within MMES and MMUS. The estimates are based on published toxicity information and apply to acute exposures for an ``average`` individual. The health effects (toxicological endpoints) used in this report are (1) the detection threshold; (2) the no-observed adverse effect level; (3) the onset of irritation/reversible effects; (4) the onset of irreversible effects; and (5) a lethal exposure, defined to be the 50% lethal level. An irreversible effect is defined as a significant effect on a person`s quality of life, e.g., serious injury. Predicted consequences are evaluated on the basis of concentration and exposure time.

• Research Organization: Martin Marietta Energy Systems, Inc., Oak Ridge, TN (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 10136228
• Report Number(s): ES/CSET-20; ON: DE94008957
• Resource Relation: Other Information: PBD: Feb 1994
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ACETONITRILE
BIOLOGICAL EFFECTS
HYDROCYANIC ACID
HYDROCHLORIC ACID
POLYCHLORINATED BIPHENYLS
SKIN
INHALATION
HEALTH HAZARDS
EXPERIMENTAL DATA
TOXICITY
COMPILED DATA
DIAGRAMS
ACCIDENTS
OCCUPATIONAL SAFETY
560300
551000
CHEMICALS METABOLISM AND TOXICOLOGY
PHYSIOLOGICAL SYSTEMS