Comparative toxicity of strontium-90 and radium-226 in beagle dogs. Progress report of second year, December 16, 1990--December 15, 1991
We are completing a 30-year study of the biological effects of {sup 90}Sr and {sup 226}Ra in the beagle in order to predict the possible long-term hazards to people from chronic exposure to low levels of irradiation. Animals received either radionuclide by several means of administration: (a) continual ingestion of {sup 90}Sr, (b) a single intravenous injection of {sup 90}Sr, or (c) a series of eight intravenous injections of {sup 226}Ra. Although administration of {sup 90}Sr and {sup 226}Ra ended at 540 days of age, the animals continued to receive chronic, low-level radiation doses from these bone-seeking radionuclides throughout life. This project is the largest single cohort study in beagles of internally deposited radionuclides. It is unique in use of the ingestion route for {sup 90}Sr and in exposure that began before birth and continued throughout development to adulthood with uniform labeling of the skeletons with {sup 90}Sr. The last of the dogs died in 1986 at age 18.5 years, but we are continuing to investigate the significance of these long-term exposures given at low dose rates with regard to cancer production, physiologic well-being, and shortening of life through the detailed records that were kept and by study of preserved materials. All the data have been successfully accumulated and entered into a main-frame computer data base management system. Current work is exclusively directed at preparing research papers summarizing the results and the associated biostatistical and survival analyses. 15 refs., 1 fig., 4 tabs.
- Research Organization:
- California Univ., Davis, CA (United States). Lab. for Energy-Related Health Research
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG03-89ER60914
- OSTI ID:
- 10104956
- Report Number(s):
- DOE/ER/60914-T1; ON: DE92003764
- Resource Relation:
- Other Information: PBD: [1991]
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparative toxicity of strontium-90 and radium-226 in beagle dogs. Report of first year, December 16, 1989--December 15, 1990
Retention and skeletal dosimetry of injected /sup 226/Ra, /sup 228/Ra, and /sup 90/Sr in beagles
Related Subjects
STRONTIUM 90
CHRONIC EXPOSURE
BIOLOGICAL RADIATION EFFECTS
RADIUM 226
BEAGLES
RADIONUCLIDE KINETICS
NEOPLASMS
RADIOINDUCTION
TISSUE DISTRIBUTION
PROGRESS REPORT
TOXICITY
SURVIVAL CURVES
RADIATION DOSES
DOSIMETRY
CARCINOGENESIS
560162
ANIMALS, PLANTS, MICROORGANISMS, AND CELLS