A hierarchy of ECM-mediated signalling tissue-specific gene expression regulates tissue-specific gene expression
A dynamic and reciprocal flow of information between cells and the extracellular matrix contributes significantly to the regulation of form and function in developing systems. Signals generated by the extracellular matrix do not act in isolation. Instead, they are processed within the context of global signalling hierarchies whose constituent inputs and outputs are constantly modulated by all the factors present in the cell's surrounding microenvironment. This is particularly evident in the mammary gland, where the construction and subsequent destruction of such a hierarchy regulates changes in tissue-specific gene expression, morphogenesis and apoptosis during each developmental cycle of pregnancy, lactation and involution.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- Life Sciences Division
- DOE Contract Number:
- DE-AC02-05CH11231; CA 57621-02
- OSTI ID:
- 1000967
- Report Number(s):
- LBNL-4093E; TRN: US201101%%740
- Journal Information:
- Current Opinion in Cell Biology, Vol. 7, Issue 5; Related Information: Journal Publication Date: 10/1995
- Country of Publication:
- United States
- Language:
- English
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