Apical polarity in three-dimensional culture systems: where to now?
Delineation of the mechanisms that establish and maintain the polarity of epithelial tissues is essential to understanding morphogenesis, tissue specificity and cancer. Three-dimensional culture assays provide a useful platform for dissecting these processes but, as discussed in a recent study in BMC Biology on the culture of mammary gland epithelial cells, multiple parameters that influence the model must be taken into account.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- Life Sciences Division
- DOE Contract Number:
- DE-AC02-05CH11231; R01CA064786, R01CA057621, U54CA126552, U54CA112970, U54CA143836
- OSTI ID:
- 1000961
- Report Number(s):
- LBNL-4096E; TRN: US201101%%734
- Journal Information:
- Journal of Biology, Vol. 9, Issue 1; Related Information: Journal Publication Date: 1/21/2010
- Country of Publication:
- United States
- Language:
- English
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