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Title: Genome sequence of the brown Norway rat yields insights into mammalian evolution

Abstract

The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90 percent of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.

Authors:
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Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Director. Office of Science. Office of Biological and Environmental Research; National Institutes of Health (US)
OSTI Identifier:
825470
Report Number(s):
LBNL-55261
R&D Project: LGFGAA; TRN: US200423%%284
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Journal Article
Journal Name:
Nature
Additional Journal Information:
Journal Volume: 428; Other Information: Journal Publication Date: 04/02/2004; PBD: 2 Feb 2004
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; GENES; MEDICINE; NORWAY; PROTEINS

Citation Formats

Gibbs, Richard A, Weinstock, George M, Metzker, Michael L, Muzny, Donna M, Sodergren, Erica J, Scherer, Steven, Scott, Graham, Steffen, David, Worley, Kim C, Burch, Paula E, Okwuonu, Geoffrey, Hines, Sandra, Lewis, Lora, DeRamo, Christine, Delgado, Oliver, Dugan-Rocha, Shannon, Miner, George, Morgan, Margaret, Hawes, Alicia, Gill, Rachel, Holt, Robert A, Adams, Mark D, Amanatides, Peter G, Baden-Tillson, Holly, Barnstead, Mary, Chin, Soo, Evans, Cheryl A, Ferriera, Steven, Fosler, Carl, Glodek, Anna, Gu, Zhiping, Jennings, Don, Kraft, Cheryl L, Nguyen, Trixie, Pfannkoch, Cynthia M, Sitter, Cynthia, Sutton, Granger G, Venter, J Craig, Woodage, Trevor, Smith, Douglas, Lee, Hong-Maei, Gustafson, Erik, Cahill, Patrick, Kana, Arnold, Doucette-Stamm, Lynn, Weinstock, Keith, Fechtel, Kim, Weiss, Robert B, Dunn, Diane M, Green, Eric D, Blakesley, Robert W, Bouffard, Gerard G, de Jong, Pieter J, Osoegawa, Kazutoyo, Zhu, Baoli, Marra, Marco, Schein, Jacqueline, Bosdet, Ian, Fjell, Chris, Jones, Steven, Krzywinski, Martin, Mathewson, Carrie, Siddiqui, Asim, Wye, Natasja, McPherson, John, Zhao, Shaying, Fraser, Claire M, Shetty, Jyoti, Shatsman, Sofiya, Geer, Keita, Chen, Yixin, Abramzon, Sofyia, Nierman, William C, Havlak, Paul H, Chen, Rui, Durbin, K James, Egan, Amy, Ren, Yanru, Song, Xing-Zhi, Li, Bingshan, Liu, Yue, Qin, Xiang, Cawley, Simon, Cooney, A J, D'Souza, Lisa M, Martin, Kirt, Wu, Jia Qian, Gonzalez-Garay, Manuel L, Jackson, Andrew R, Kalafus, Kenneth J, McLeod, Michael P, Milosavljevic, Aleksandar, Virk, Davinder, Volkov, Andrei, Wheeler, David A, Zhang, Zhengdong, Bailey, Jeffrey A, Eichler, Evan E, Tuzun, Eray, Birney, Ewan, Mongin, Emmanuel, Ureta-Vidal, Abel, Woodwark, Cara, Zdobnov, Evgeny, Bork, Peer, Suyama, Mikita, Torrents, David, Alexandersson, Marina, Trask, Barbara J, Young, Janet M, and et al. Genome sequence of the brown Norway rat yields insights into mammalian evolution. United States: N. p., 2004. Web.
Gibbs, Richard A, Weinstock, George M, Metzker, Michael L, Muzny, Donna M, Sodergren, Erica J, Scherer, Steven, Scott, Graham, Steffen, David, Worley, Kim C, Burch, Paula E, Okwuonu, Geoffrey, Hines, Sandra, Lewis, Lora, DeRamo, Christine, Delgado, Oliver, Dugan-Rocha, Shannon, Miner, George, Morgan, Margaret, Hawes, Alicia, Gill, Rachel, Holt, Robert A, Adams, Mark D, Amanatides, Peter G, Baden-Tillson, Holly, Barnstead, Mary, Chin, Soo, Evans, Cheryl A, Ferriera, Steven, Fosler, Carl, Glodek, Anna, Gu, Zhiping, Jennings, Don, Kraft, Cheryl L, Nguyen, Trixie, Pfannkoch, Cynthia M, Sitter, Cynthia, Sutton, Granger G, Venter, J Craig, Woodage, Trevor, Smith, Douglas, Lee, Hong-Maei, Gustafson, Erik, Cahill, Patrick, Kana, Arnold, Doucette-Stamm, Lynn, Weinstock, Keith, Fechtel, Kim, Weiss, Robert B, Dunn, Diane M, Green, Eric D, Blakesley, Robert W, Bouffard, Gerard G, de Jong, Pieter J, Osoegawa, Kazutoyo, Zhu, Baoli, Marra, Marco, Schein, Jacqueline, Bosdet, Ian, Fjell, Chris, Jones, Steven, Krzywinski, Martin, Mathewson, Carrie, Siddiqui, Asim, Wye, Natasja, McPherson, John, Zhao, Shaying, Fraser, Claire M, Shetty, Jyoti, Shatsman, Sofiya, Geer, Keita, Chen, Yixin, Abramzon, Sofyia, Nierman, William C, Havlak, Paul H, Chen, Rui, Durbin, K James, Egan, Amy, Ren, Yanru, Song, Xing-Zhi, Li, Bingshan, Liu, Yue, Qin, Xiang, Cawley, Simon, Cooney, A J, D'Souza, Lisa M, Martin, Kirt, Wu, Jia Qian, Gonzalez-Garay, Manuel L, Jackson, Andrew R, Kalafus, Kenneth J, McLeod, Michael P, Milosavljevic, Aleksandar, Virk, Davinder, Volkov, Andrei, Wheeler, David A, Zhang, Zhengdong, Bailey, Jeffrey A, Eichler, Evan E, Tuzun, Eray, Birney, Ewan, Mongin, Emmanuel, Ureta-Vidal, Abel, Woodwark, Cara, Zdobnov, Evgeny, Bork, Peer, Suyama, Mikita, Torrents, David, Alexandersson, Marina, Trask, Barbara J, Young, Janet M, & et al. Genome sequence of the brown Norway rat yields insights into mammalian evolution. United States.
Gibbs, Richard A, Weinstock, George M, Metzker, Michael L, Muzny, Donna M, Sodergren, Erica J, Scherer, Steven, Scott, Graham, Steffen, David, Worley, Kim C, Burch, Paula E, Okwuonu, Geoffrey, Hines, Sandra, Lewis, Lora, DeRamo, Christine, Delgado, Oliver, Dugan-Rocha, Shannon, Miner, George, Morgan, Margaret, Hawes, Alicia, Gill, Rachel, Holt, Robert A, Adams, Mark D, Amanatides, Peter G, Baden-Tillson, Holly, Barnstead, Mary, Chin, Soo, Evans, Cheryl A, Ferriera, Steven, Fosler, Carl, Glodek, Anna, Gu, Zhiping, Jennings, Don, Kraft, Cheryl L, Nguyen, Trixie, Pfannkoch, Cynthia M, Sitter, Cynthia, Sutton, Granger G, Venter, J Craig, Woodage, Trevor, Smith, Douglas, Lee, Hong-Maei, Gustafson, Erik, Cahill, Patrick, Kana, Arnold, Doucette-Stamm, Lynn, Weinstock, Keith, Fechtel, Kim, Weiss, Robert B, Dunn, Diane M, Green, Eric D, Blakesley, Robert W, Bouffard, Gerard G, de Jong, Pieter J, Osoegawa, Kazutoyo, Zhu, Baoli, Marra, Marco, Schein, Jacqueline, Bosdet, Ian, Fjell, Chris, Jones, Steven, Krzywinski, Martin, Mathewson, Carrie, Siddiqui, Asim, Wye, Natasja, McPherson, John, Zhao, Shaying, Fraser, Claire M, Shetty, Jyoti, Shatsman, Sofiya, Geer, Keita, Chen, Yixin, Abramzon, Sofyia, Nierman, William C, Havlak, Paul H, Chen, Rui, Durbin, K James, Egan, Amy, Ren, Yanru, Song, Xing-Zhi, Li, Bingshan, Liu, Yue, Qin, Xiang, Cawley, Simon, Cooney, A J, D'Souza, Lisa M, Martin, Kirt, Wu, Jia Qian, Gonzalez-Garay, Manuel L, Jackson, Andrew R, Kalafus, Kenneth J, McLeod, Michael P, Milosavljevic, Aleksandar, Virk, Davinder, Volkov, Andrei, Wheeler, David A, Zhang, Zhengdong, Bailey, Jeffrey A, Eichler, Evan E, Tuzun, Eray, Birney, Ewan, Mongin, Emmanuel, Ureta-Vidal, Abel, Woodwark, Cara, Zdobnov, Evgeny, Bork, Peer, Suyama, Mikita, Torrents, David, Alexandersson, Marina, Trask, Barbara J, Young, Janet M, and et al. 2004. "Genome sequence of the brown Norway rat yields insights into mammalian evolution". United States.
@article{osti_825470,
title = {Genome sequence of the brown Norway rat yields insights into mammalian evolution},
author = {Gibbs, Richard A and Weinstock, George M and Metzker, Michael L and Muzny, Donna M and Sodergren, Erica J and Scherer, Steven and Scott, Graham and Steffen, David and Worley, Kim C and Burch, Paula E and Okwuonu, Geoffrey and Hines, Sandra and Lewis, Lora and DeRamo, Christine and Delgado, Oliver and Dugan-Rocha, Shannon and Miner, George and Morgan, Margaret and Hawes, Alicia and Gill, Rachel and Holt, Robert A and Adams, Mark D and Amanatides, Peter G and Baden-Tillson, Holly and Barnstead, Mary and Chin, Soo and Evans, Cheryl A and Ferriera, Steven and Fosler, Carl and Glodek, Anna and Gu, Zhiping and Jennings, Don and Kraft, Cheryl L and Nguyen, Trixie and Pfannkoch, Cynthia M and Sitter, Cynthia and Sutton, Granger G and Venter, J Craig and Woodage, Trevor and Smith, Douglas and Lee, Hong-Maei and Gustafson, Erik and Cahill, Patrick and Kana, Arnold and Doucette-Stamm, Lynn and Weinstock, Keith and Fechtel, Kim and Weiss, Robert B and Dunn, Diane M and Green, Eric D and Blakesley, Robert W and Bouffard, Gerard G and de Jong, Pieter J and Osoegawa, Kazutoyo and Zhu, Baoli and Marra, Marco and Schein, Jacqueline and Bosdet, Ian and Fjell, Chris and Jones, Steven and Krzywinski, Martin and Mathewson, Carrie and Siddiqui, Asim and Wye, Natasja and McPherson, John and Zhao, Shaying and Fraser, Claire M and Shetty, Jyoti and Shatsman, Sofiya and Geer, Keita and Chen, Yixin and Abramzon, Sofyia and Nierman, William C and Havlak, Paul H and Chen, Rui and Durbin, K James and Egan, Amy and Ren, Yanru and Song, Xing-Zhi and Li, Bingshan and Liu, Yue and Qin, Xiang and Cawley, Simon and Cooney, A J and D'Souza, Lisa M and Martin, Kirt and Wu, Jia Qian and Gonzalez-Garay, Manuel L and Jackson, Andrew R and Kalafus, Kenneth J and McLeod, Michael P and Milosavljevic, Aleksandar and Virk, Davinder and Volkov, Andrei and Wheeler, David A and Zhang, Zhengdong and Bailey, Jeffrey A and Eichler, Evan E and Tuzun, Eray and Birney, Ewan and Mongin, Emmanuel and Ureta-Vidal, Abel and Woodwark, Cara and Zdobnov, Evgeny and Bork, Peer and Suyama, Mikita and Torrents, David and Alexandersson, Marina and Trask, Barbara J and Young, Janet M and et al.},
abstractNote = {The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90 percent of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.},
doi = {},
url = {https://www.osti.gov/biblio/825470}, journal = {Nature},
number = ,
volume = 428,
place = {United States},
year = {Mon Feb 02 00:00:00 EST 2004},
month = {Mon Feb 02 00:00:00 EST 2004}
}