The Genome of the Western Clawed Frog Xenopus tropicalis
Journal Article
·
· Science
OSTI ID:1010537
The western clawed frog Xenopus tropicalis is an important model for vertebrate development that combines experimental advantages of the African clawed frog Xenopus laevis with more tractable genetics. Here we present a draft genome sequence assembly of X. tropicalis. This genome encodes over 20,000 protein-coding genes, including orthologs of at least 1,700 human disease genes. Over a million expressed sequence tags validated the annotation. More than one-third of the genome consists of transposable elements, with unusually prevalent DNA transposons. Like other tetrapods, the genome contains gene deserts enriched for conserved non-coding elements. The genome exhibits remarkable shared synteny with human and chicken over major parts of large chromosomes, broken by lineage-specific chromosome fusions and fissions, mainly in the mammalian lineage.
- Research Organization:
- Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA (US)
- Sponsoring Organization:
- Genomics Division
- DOE Contract Number:
- AC02-05CH11231
- OSTI ID:
- 1010537
- Report Number(s):
- LBNL-3320E
- Journal Information:
- Science, Journal Name: Science; ISSN 0193-4511; ISSN SCEHDK
- Country of Publication:
- United States
- Language:
- English
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