Mutagenicity of urine from mice exposed orally to nitrite and various aminated antiparasitic drugs
- U.N.A.M. (Mexico)
Mutagenic N-nitroso compound formation from the in vitro reaction of amebicides and anthelmintic drugs, which are pyrimidine derivatives or contain secondary aliphatic amines or heterocyclic nitrogens, has been previously described. Under similar conditions, antiparasitic drugs containing halogenated derivatives of tertiary amines or quaternary ammonium salts do not form mutagenic nitrosated compounds. In the present study the mutagenic activity of mouse urine was determined after oral administration of sodium nitrite and the two above-mentioned groups of drugs. Results show that the simultaneous administration of piperazine or chloroquine with sodium nitrite produced urinary mutagens that appeared conjugated as glucuronides, whereas pyrantel pamoate and dehydroemetine in the presence of nitrite caused only slightly mutagenic urine. No mutagenic activity was detected in the urine of mice to which halogenated derivatives of tertiary amines (iodochlorhydroxyquin) or quaternary ammonium salts (bephenium hydroxynaphthoate) were administered together with nitrite.
- OSTI ID:
- 7190580
- Journal Information:
- Environmental and Molecular Mutagenesis; (USA), Vol. 14:1; ISSN 0893-6692
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANTIMICROBIAL AGENTS
ORAL ADMINISTRATION
NITRITES
NITROSO COMPOUNDS
BIOCHEMISTRY
URINE
MUTAGEN SCREENING
MICE
PIPERAZINES
SODIUM COMPOUNDS
ALKALI METAL COMPOUNDS
ANIMALS
ANTI-INFECTIVE AGENTS
AZINES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHEMISTRY
DRUGS
HETEROCYCLIC COMPOUNDS
MAMMALS
MATERIALS
NITROGEN COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
PYRAZINES
RODENTS
SCREENING
VERTEBRATES
WASTES
560300* - Chemicals Metabolism & Toxicology