The carcinogenic danger of nitrite pollution of the environment

Journal Article · Wed Oct 31 23:00:00 EST 1990 · Journal of Environmental Pathology, Toxicology and Oncology; (United States)

OSTI ID:5590685

Rubenchik, B L; Osinkovskaya, N D; Mikhailenko, V M; Furman, M A; Boim, T M ^[1]

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1. Laboratory of Ecology and Carcinogenesis, R.E. Kavetsky Institute for Oncology Problems, Kiev (USSR)

Presented are the literature data as well as the results of our own investigations on the genotoxic and carcinogenic effects of sodium nitrite (SN). The carcinogenicity of SN detected in animal experiments appears to be related to the formation of nitroso compounds from endogenous nitrosable precursors. Sodium nitrite possesses transforming and promoting effects in cell cultures, as well as mutagenic effects in the bacterial systems, where the predominant effect of SN was compared to that of N-nitrosodimethylamine (NDMA). Prolonged pretreatment with SN amplifies the liver DNA damage in rats in case of NDMA endogenous synthesis.

• OSTI ID: 5590685
• Journal Information: Journal of Environmental Pathology, Toxicology and Oncology; (United States), Journal Name: Journal of Environmental Pathology, Toxicology and Oncology; (United States) Vol. 10:6; ISSN 0731-8898; ISSN JEPOE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
DIGESTIVE SYSTEM
DISEASES
DNA
GENETIC EFFECTS
GLANDS
LIVER
MAMMALS
NEOPLASMS
NITRITES
NITROGEN COMPOUNDS
NITROSO COMPOUNDS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOGENESIS
RATS
RODENTS
TOXICITY
VERTEBRATES