Potentially-lethal damage and radioprotection in human cells exposed to californium-252

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Nucl. Sci. Appl.; (United States)

OSTI ID:7062985

Schroy, C B; Goud, S N; Magura, C; Feola, J M; Maruyama, Y

Cultured human T-1E cells were irradiated with californium-252 neutrons and gamma rays. When 2 mm caffeine was present in the medium for 47 h after irradiation cell survival (assayed by colony formation) was decreased significantly. When 2 m dimethylsulfoxide was present during the irradiations radioprotection was observed using the same assay. The caffeine data indicate that potentially-lethal lesions exist in cells after californium exposure and that these lesions can be made lethal when they would otherwise be repaired. The DMSO data indicate that radioprotection from californium exposure can be achieved and that scanvengable free radicals play an important role in Cf-252 lethality.

• Research Organization: Cleveland Clinic Foundation, Dept. of Radiation Therapy, Cleveland, OH
• OSTI ID: 7062985
• Journal Information: Nucl. Sci. Appl.; (United States), Vol. 2:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
LETHAL IRRADIATION
CALIFORNIUM 252
RADIATION HAZARDS
BIOASSAY
CAFFEINE
CELL CULTURES
DATA ANALYSIS
DMSO
GAMMA RADIATION
HUMAN POPULATIONS
LETHAL DOSES
NEUTRON EMISSION
PHOTON EMISSION
RADIATION PROTECTION
RADICALS
SURVIVAL TIME
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANALEPTICS
AROMATICS
AZAARENES
CALIFORNIUM ISOTOPES
CENTRAL NERVOUS SYSTEM AGENTS
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EMISSION
EVEN-EVEN NUCLEI
HAZARDS
HEALTH HAZARDS
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
POPULATIONS
PURINES
RADIATIONS
RADIOISOTOPES
SULFOXIDES
XANTHINES
YEARS LIVING RADIOISOTOPES
560151* - Radiation Effects on Animals- Man
560161 - Radionuclide Effects
Kinetics
& Toxicology- Man