Evaluation of high-dose vitamin E as a radioprotective agent

Journal Article · Mon Sep 01 00:00:00 EDT 1980 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.136.3.7403557· OSTI ID:7029052

Rostock, R A; Stryker, J A; Abt, A B

Sixty male Sprague Dawley rats were randomly divided into six equal groups and given 0, 1500 rads (15 Gy), and 2000 rads (20 Gy) whole thoracic irradiation from a cobalt-60 source via an anterior portal. Thirty animals received a 2.5% vitamin E diet for two weeks prior to irradiation and, in addition, each was given a single intraperitoneal injection of water-soluble ..cap alpha..-tocopherol (150 mg) four hours prior to irradiation. Serum vitamin E levels were 646 +- 76 ..mu..g/ml for vitamin E groups and 6.0 +- 2.4 ..mu..g/ml for controls. Comparison of the 180-day survival curves and histologic studies performed on the lungs and hearts of the surviving animals showed no statistically significant difference between the vitamin E and control group.

• Research Organization: Pennsylvania State Univ., Hershey
• OSTI ID: 7029052
• Journal Information: Radiology; (United States), Vol. 136:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HEART
BIOLOGICAL RADIATION EFFECTS
LUNGS
VITAMIN E
RADIOSENSITIVITY EFFECTS
CHEST
COBALT 60
COMPARATIVE EVALUATIONS
DIET
GAMMA RADIATION
LOCAL IRRADIATION
PARTIAL BODY IRRADIATION
RADIATION DOSES
RADIOPROTECTIVE SUBSTANCES
RATS
RESPONSE MODIFYING FACTORS
SURVIVAL CURVES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CARDIOVASCULAR SYSTEM
COBALT ISOTOPES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
VITAMINS
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals