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Title: Investigation of the modifying effects of vitamin A and hypoxic cell sensitizers in radiation carcinogenesis in mice

Abstract

The effect of vitamin A (retinyl acetate) and three hypoxic cell sensitizers (metronidazole, misonidazole and desmethylmisonidazole) on lung tumor development in strain A mice exposed to radiation was assessed. In experiments involving vitamin A, two groups of mice were fed a low vitamin A diet (< 100 IU/100g diet) while the two other groups were fed a high vitamin A diet (800 IU/100 g diet). After two weeks one group maintained on the high vitamin A diet and one group maintained on the low vitamin A diet were given an acute dose of 500 rad of gamma radiation to the thoracic region. Mice were killed, their lungs were removed and the number of surface adenomas were counted. There was a significant increase in the number of mice bearing lung tumors and the mean number of lung tumors per mouse in the irradiated group maintained on the high vitamin A diet at 40 weeks post irradiation as compared to the irradiated group maintained on a low vitamin A diet. In the other experiment two dose levels of the hypoxic cell sensitizers, 0.2 mg/g and 0.6 mg/g, were used either alone or in combination with 900 rad of gamma radiation in amore » fractionated dose schedule of twice a week for three weeks. In the groups of mice which received hypoxic cell sensitizers only, the prevalence and the mean number of lung tumors per mouse were somewhat increased in the higher dose group (0.6 mg/g) of misonidazole but was not significantly different from the control animals in the other two sensitizer groups. The combination of hypoxic cell sensitizer and radiation did not show any significant enhancement of lung tumor response when compared with the group which received radiation only. The dose of radiation used in this study significantly enhanced lung tumor formation in mice when compared with the control group.« less

Authors:
Publication Date:
Research Org.:
Texas Univ., Houston (USA). School of Public Health
OSTI Identifier:
5123210
Resource Type:
Thesis/Dissertation
Resource Relation:
Other Information: Thesis (Ph. D.)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ADENOMAS; RADIOINDUCTION; LUNGS; RADIOSENSITIZERS; BIOLOGICAL EFFECTS; VITAMIN A; ACUTE IRRADIATION; CARCINOGENESIS; DIET; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL DATA; FRACTIONATED IRRADIATION; GAMMA RADIATION; METRONIDAZOLE; MICE; RADIOSENSITIVITY EFFECTS; ACUTE EXPOSURE; ALCOHOLS; ANIMALS; ANTINEOPLASTIC DRUGS; AZOLES; BODY; DATA; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMIDAZOLES; INFORMATION; IONIZING RADIATIONS; IRRADIATION; MAMMALS; NEOPLASMS; NITRO COMPOUNDS; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PATHOGENESIS; RADIATIONS; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES; VITAMINS; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Mian, T.A.. Investigation of the modifying effects of vitamin A and hypoxic cell sensitizers in radiation carcinogenesis in mice. United States: N. p., 1982. Web.
Mian, T.A.. Investigation of the modifying effects of vitamin A and hypoxic cell sensitizers in radiation carcinogenesis in mice. United States.
Mian, T.A.. Fri . "Investigation of the modifying effects of vitamin A and hypoxic cell sensitizers in radiation carcinogenesis in mice". United States. doi:.
@article{osti_5123210,
title = {Investigation of the modifying effects of vitamin A and hypoxic cell sensitizers in radiation carcinogenesis in mice},
author = {Mian, T.A.},
abstractNote = {The effect of vitamin A (retinyl acetate) and three hypoxic cell sensitizers (metronidazole, misonidazole and desmethylmisonidazole) on lung tumor development in strain A mice exposed to radiation was assessed. In experiments involving vitamin A, two groups of mice were fed a low vitamin A diet (< 100 IU/100g diet) while the two other groups were fed a high vitamin A diet (800 IU/100 g diet). After two weeks one group maintained on the high vitamin A diet and one group maintained on the low vitamin A diet were given an acute dose of 500 rad of gamma radiation to the thoracic region. Mice were killed, their lungs were removed and the number of surface adenomas were counted. There was a significant increase in the number of mice bearing lung tumors and the mean number of lung tumors per mouse in the irradiated group maintained on the high vitamin A diet at 40 weeks post irradiation as compared to the irradiated group maintained on a low vitamin A diet. In the other experiment two dose levels of the hypoxic cell sensitizers, 0.2 mg/g and 0.6 mg/g, were used either alone or in combination with 900 rad of gamma radiation in a fractionated dose schedule of twice a week for three weeks. In the groups of mice which received hypoxic cell sensitizers only, the prevalence and the mean number of lung tumors per mouse were somewhat increased in the higher dose group (0.6 mg/g) of misonidazole but was not significantly different from the control animals in the other two sensitizer groups. The combination of hypoxic cell sensitizer and radiation did not show any significant enhancement of lung tumor response when compared with the group which received radiation only. The dose of radiation used in this study significantly enhanced lung tumor formation in mice when compared with the control group.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1982},
month = {Fri Jan 01 00:00:00 EST 1982}
}

Thesis/Dissertation:
Other availability
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