Gastrointestinal peptide levels in obese and anorexic females

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Proceedings of the Society for Experimental Biology and Medicine; (USA)

OSTI ID:7018702

Pasley, J N; Rice, R L; McCullough, S S; McKay, D W; Rayford, P L ^[1]

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1. Univ. of Arkansas for Medical Sciences, Little Rock (USA)

The role of gastrointestinal peptides in eating disorders has yet to be determined. Methods: In this study we examined plasma levels of gastrin (G), cholecystokinin (CCK), and pancreatic polypeptide (PP) in adolescent anorexic, and obese female subjects hospitalized for feeding behavior disorders. Six anorexic, six obese and six control young females (ages 13-26) were studied after an overnight fast and after consuming a liquid test meal. The liquid test meal (Ensure, Ross Laboratories; Columbus OH) consisted of 14% calories as protein, 31.5% calories as fat and 54.5% calories as carbohydrate in a 240ml volume. Plasma levels of gastrointestinal peptides, G, CCK and PP were determined by specific radioimmunoassay. The data were analyzed by one way analysis of variance and the Student's t-test. Results: show that fasting levels of G were greater in control and obese groups than the anorexic subjects. Postprandial G levels for controls were higher than the anorexic, and obese groups respectively. When fasting and postprandial G levels were compared among the same groups only the controls increased after eating. Fasting CCK levels were lower in control and anorexic groups than the obese group. Postprandial CCK levels were higher among control patients compared to anorexic and obese subjects. When fasting and postprandial CCK levels were compared among groups, only control levels increased after eating. Fasting and postprandial PP levels were not different between groups. Postprandial PP levels increased over fasting PP levels only in controls.

• OSTI ID: 7018702
• Journal Information: Proceedings of the Society for Experimental Biology and Medicine; (USA), Vol. 191:1; ISSN 0037-9727
• Country of Publication: United States
• Language: English

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