Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes
Journal Article
·
· Journal of Immunology; (United States)
OSTI ID:7009437
- DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA (United States)
- National Cancer Institute, Frederick, MD (United States)
The nucleotide sequence of a 7.2-kb segment containing the mouse IL-10 (mIL-10) gene was determined. Comparison to the mIL-10 cDNA sequence revealed the presence of five exons that span [approximately]5.1 kb of genomic DNA. The noncoding regions of the mIL-10 gene contain sequences that have been associated with transcriptional regulation of several cytokine genes. The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1. 35 refs., 4 figs., 3 tabs.
- OSTI ID:
- 7009437
- Journal Information:
- Journal of Immunology; (United States), Vol. 148:11; ISSN 0022-1767
- Country of Publication:
- United States
- Language:
- English
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