Effect of hyperthermia and endotoxin induced fever on the blood-brain barrier

Thesis/Dissertation · Thu Jan 01 00:00:00 EST 1987

OSTI ID:7000019

Gustafson, A N

The purpose of this study was to determine the effect of hyperthermia and fever, on the permeability characteristics of the BBB. A group of rats were maintained in a warm environment until their body temperature became elevated by 1.5/sup 0/C. The permeability of the BBB was determined by injecting the rats with /sup 14/C-sucrose (MW 340) and /sup 3/H-dextran (MW 70,000) and calculating the permeability-surface area product. When hyperthermic animals were compared to controls maintained in a neutral environment it was found that BBB permeability was increased for the smaller radioisotope only. A third group of animals was injected with endotoxin to induce fever. Body temperature was elevated by 1.4/sup 0/C which was similar to the hyperthermic group. BBB permeability to both radioisotopes was not significantly different from control animals. Another group of animals was given a higher dose of endotoxin which produced shock. It was found that BBB permeability was increased for /sup 14/C-sucrose in all brain regions and also for /sup 3/H-dextran in the cerebellum.

• Research Organization: Indiana Univ., Bloomington (USA)
• OSTI ID: 7000019
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BLOOD-BRAIN BARRIER
PERMEABILITY
ENDOTOXINS
BIOLOGICAL EFFECTS
HYPERTHERMIA
CARBON 14 COMPOUNDS
DEXTRAN
FEVER
RATS
SACCHAROSE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
ANTIGENS
BLOOD SUBSTITUTES
BODY TEMPERATURE
CARBOHYDRATES
DISACCHARIDES
DRUGS
HEMATOLOGIC AGENTS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
POLYSACCHARIDES
RODENTS
SACCHARIDES
SYMPTOMS
TOXIC MATERIALS
TOXINS
VERTEBRATES
550901* - Pathology- Tracer Techniques