Microwave radiation (2450 MHz) alters the endotoxin-induced hypothermic response of rats

Journal Article · Tue Jan 01 04:00:00 EST 1980 · Bioelectromagnetics (N.Y.); (United States)

DOI:https://doi.org/10.1002/bem.2250010402· OSTI ID:5578142

Smialowicz, R J; Compton, K L; Riddle, M M; Rogers, R R; Brugnolotti, P L

The parenteral administration of bacterial endotoxin to rats causes a hypothermia that is maximal after approximately 90 minutes. When endotoxin-injected rats were held in a controlled environment at 22 degree C and 50% relative humidity and exposed for 90 minutes to microwaves (2450 MHz, CW) at 1 mW/cm2, significant increases were observed in body temperature compared with endotoxin-treated, sham-irradiated rats. The magnitude of the response was related to power density (10 mW/cm2 greater than 5 mW/cm2 greater than 1 mW/cm2). Saline-injected rats exposed for 90 minutes at 5 mW/cm2 (specific absorption rate approximately 1.0 mW/g) showed no significant increase in body temperature compared with saline-injected, sham-irradiated rats. The hypothermia induced by endotoxin in rats was also found to be affected by ambient temperature alone. Increases in ambient temperature above 22 degree C in the absence of microwaves caused a concomitant increase in body temperature. This study reveals that subtle microwave heating is detectable in endotoxin-treated rats that have impaired thermoregulatory capability. These results indicate that the interpretation of microwave-induced biological effects observed in animals at comparable rates and levels of energy absorption should include a consideration of the thermogenic potential of microwave.

• OSTI ID: 5578142
• Journal Information: Bioelectromagnetics (N.Y.); (United States), Journal Name: Bioelectromagnetics (N.Y.); (United States) Vol. 1:4; ISSN BLCTD
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560400* -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
CONTROL
ELECTROMAGNETIC RADIATION
ENDOTOXINS
ENERGY ABSORPTION
HYPOTHERMIA
MAMMALS
MATERIALS
MICROWAVE RADIATION
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
TEMPERATURE CONTROL
THERMOREGULATION
TOXIC MATERIALS
TOXINS
VERTEBRATES